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1.发明申请POLYMER NANOFIBER SCAFFOLD FOR A HEPARIN / FIBRIN BASED GROWTH FACTOR DELIVERY SYSTEM 失效用于基于蛋白/纤维素的生长因子递送系统的聚合物纳米纤维公开(公告)号：US20130004541A1
公开(公告)日：2013-01-03
申请号：US13343869
申请日：2012-01-05
申请人： Stavros Thomopoulos , Shelly Sakiyama-Elbert , Matthew Silva , Richard Gelberman , Younan Xia , Andrea Schwartz , Jingwei Xie
发明人： Stavros Thomopoulos , Shelly Sakiyama-Elbert , Matthew Silva , Richard Gelberman , Younan Xia , Andrea Schwartz , Jingwei Xie
CPC分类号： A61L27/54 , A61F2002/30766 , A61K38/00 , A61L27/18 , A61L27/26 , C07K14/47 , C07K14/475 , C07K14/75 , C12N9/6429 , Y10T156/10
摘要： A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.
摘要翻译： 生长因子递送支架将基于肝素/纤维蛋白的递送系统（HBDS）与基于用于组织（例如肌腱和韧带）修复的聚合物纳米纤维的骨架组合。 与现有技术的HBDS系统的凝胶状稠度相比，支架具有改善的手术处理性质，并且保留了递送间充质细胞并控制生长因子释放的能力。 支架的一个应用是用于屈肌腱修复的间充质干细胞（MSC）治疗。 支架可以以持续的方式输送生长因子，可以植入用于屈肌腱修复，是生物相容的，并且不是细胞毒性的。 生长因子递送支架也可用于外科手术修复对骨，肌肉，软骨或其他组织的损伤。
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2.发明授权Polymer nanofiber scaffold for a heparin / fibrin based growth factor delivery system 失效用于肝素/纤维蛋白的生长因子递送系统的聚合物纳米纤维支架公开(公告)号：US08673323B2
公开(公告)日：2014-03-18
申请号：US13343869
申请日：2012-01-05
申请人： Stavros Thomopoulos , Shelly Sakiyama-Elbert , Matthew Silva , Richard Gelberman , Younan Xia , Andrea Schwartz , Jingwei Xie
发明人： Stavros Thomopoulos , Shelly Sakiyama-Elbert , Matthew Silva , Richard Gelberman , Younan Xia , Andrea Schwartz , Jingwei Xie
CPC分类号： A61L27/54 , A61F2002/30766 , A61K38/00 , A61L27/18 , A61L27/26 , C07K14/47 , C07K14/475 , C07K14/75 , C12N9/6429 , Y10T156/10
摘要： A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.
摘要翻译： 生长因子递送支架将基于肝素/纤维蛋白的递送系统（HBDS）与基于用于组织（例如肌腱和韧带）修复的聚合物纳米纤维的骨架组合。 与现有技术的HBDS系统的凝胶状稠度相比，支架具有改善的手术处理性质，并且保留了递送间充质细胞并控制生长因子释放的能力。 支架的一个应用是用于屈肌腱修复的间充质干细胞（MSC）治疗。 支架可以以持续的方式输送生长因子，可以植入用于屈肌腱修复，是生物相容的，并且不是细胞毒性的。 生长因子递送支架也可用于外科手术修复对骨，肌肉，软骨或其他组织的损伤。
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公开(公告)号：US10401156B2
公开(公告)日：2019-09-03
申请号：US16110023
申请日：2018-08-23
摘要： A computer-implemented method for determining a quantification of the deformation of the sample is implemented using a computer device in communication with a memory. The method includes receiving, by the computer device, a first image of the sample and a second image of the sample. The method also includes registering the first image to the second image using a warping function. The warping function maps a plurality of pixels in the first image to a plurality of pixels in the second image. A first displacement field for the sample is determined based on the warping function, where the first displacement field includes at least a portion of the warping function. A first quantification of the deformation of the sample is determined based at least in part on the displacement field.
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4.发明申请公开(公告)号：US20190219382A1
公开(公告)日：2019-07-18
申请号：US16110023
申请日：2018-08-23
CPC分类号： G01B11/16 , G06T7/30 , G06T2207/10004 , G06T2207/30024 , G06T2207/30108
摘要： A computer-implemented method for determining a quantification of the deformation of the sample is implemented using a computer device in communication with a memory. The method includes receiving, by the computer device, a first image of the sample and a second image of the sample. The method also includes registering the first image to the second image using a warping function. The warping function maps a plurality of pixels in the first image to a plurality of pixels in the second image. A first displacement field for the sample is determined based on the warping function, where the first displacement field includes at least a portion of the warping function. A first quantification of the deformation of the sample is determined based at least in part on the displacement field.
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公开(公告)号：US20170360554A1
公开(公告)日：2017-12-21
申请号：US15455792
申请日：2017-03-10
CPC分类号： A61F2/08 , A61B17/06166 , A61B17/1146 , A61B2017/00884 , A61B2017/00951 , A61F2/28 , A61F2220/005 , A61L17/145 , A61L24/0005 , A61L24/0015 , A61L24/0031 , A61L2300/414 , A61L2300/64 , A61L2430/02 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/30
摘要： Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including CTGF/CCN2, or cells.
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