公开(公告)号：US06272370B1

公开(公告)日：2001-08-07

申请号：US09131031

申请日：1998-08-07

申请人： George T. Gillies ,  John Kucharczyk ,  William C. Broaddus ,  Richard Latchaw

发明人： George T. Gillies ,  John Kucharczyk ,  William C. Broaddus ,  Richard Latchaw

IPC分类号： A61B505

CPC分类号： A61M25/0105 ,  A61B2090/3954 ,  A61M25/0127

摘要： The present invention comprises a device and method for targeted drug delivery, and especially intracranial inflsion or retroperfusion drug delivery using nonlinear magnetic stereotaxis in combination with magnetic resonance (MR) imaging and/or X-ray visualization. An MR-visible and/or X-ray visible drug delivery device is positioned by non-linear magnetic stereotaxis at a site such as an intracranial target site, its location is verified via MR imaging, and it is then used to deliver a biologically active material such as a diagnostic or therapeutic drug solution into that site (such as the brain) at constant or variable rates. The spatial distribution kinetics of the injected or infised drug agent may be monitored quantitatively and non-invasively using real-time MR-imaging such as water proton directional diffusion MR imaging, to establish the efficacy of targeted drug delivery.

摘要翻译： 本发明包括用于靶向药物递送的装置和方法，特别是使用非线性磁立体定位与磁共振（MR）成像和/或X射线可视化相结合的颅内灌注或后灌注药物递送。 通过非线性磁立体定位在诸如颅内靶位点的位置定位MR可见和/或X射线可见药物递送装置，其位置通过MR成像验证，然后用于递送生物活性 材料，例如以恒定或可变速率进入该部位（例如脑）的诊断或治疗药物溶液。 可以使用实时MR成像（例如水质子定向扩散MR成像）定量和非侵入性地监测注射或致死药物的空间分布动力学，以确定靶向药物递送的功效。

公开(公告)号：US06463317B1

公开(公告)日：2002-10-08

申请号：US09081319

申请日：1998-05-19

申请人： John Kucharczyk ,  Richard Latchaw

发明人： John Kucharczyk ,  Richard Latchaw

IPC分类号： A61B5055

CPC分类号： A61F2/958 ,  A61B5/02014 ,  A61B5/055 ,  A61B5/411 ,  A61B5/4839 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12136 ,  A61B17/1214 ,  A61B17/1219 ,  A61B2090/374

摘要： This invention provides a method and a device for treating hemodynamically significant aneurysms especially in the intracranial and extracranial circulation regions using either X-ray fluoroscopy or real-time magnetic resonance (MR) imaging guidance. An MR-visible parachute-shaped occlusion device, e.g., containing multiple elongated filamentary loops made of a memory metal, elastomeric hydrogel or other expansile material, is deployed into the aneurysm by radial expansion of the expansile material outwardly into contact with the interior aneurysm surface. The device is firmly positioned against the interior aneurysm surface using a coating which adheres to that interior aneurysm surface. The device may be filled with a hardenable polymer for permanent and complete aneurysm occlusion. Wide-neck aneurysms may be treated with the same device, with the addition of a temporary balloon expanded in the parent vessel to allow expansion of the occluding device within the aneurysm, instillation of the polymer into the device, and detachment of the device from the transporting catheter. Detachment of the aneurysm occlusion device from a transport catheter is achieved by mechanical, electrical and/or chemical decoupling. A coating applied to the surface of the parachute device may induce thrombotic occlusion of the aneurysm by timed delivery of biologic modifier drugs which promote collagen formation, fibroblast growth, and endothelial ingrowth within the aneurysm. The catheter systems may have attached microcoils or may be impregnated with MR-visible agents to permit visualization in MR imaging systems.

摘要翻译： 本发明提供一种用于使用X射线荧光透视或实时磁共振（MR）成像指导，特别是在颅内和颅外循环区域中治疗血液动力学显着的动脉瘤的方法和装置。 MR记录的降落伞形闭塞装置，例如包含由记忆金属，弹性体水凝胶或其它可膨胀材料制成的多个细长丝状环，通过向外膨胀膨胀材料径向膨胀而与内部动脉瘤表面接触而部署到动脉瘤中 。 该装置使用粘附于内部动脉瘤表面的涂层牢固地抵靠内部动脉瘤表面定位。 该装置可以填充用于永久和完全动脉瘤闭塞的可硬化聚合物。 可以使用相同的装置处理宽颈动脉瘤，同时在母体血管中添加临时囊扩张，以允许阻塞装置在动脉瘤内膨胀，将聚合物滴入装置中，并将装置从 运输导管。 通过机械，电和/或化学去耦实现动脉瘤闭塞装置从运输导管的分离。 施加到降落伞装置的表面上的涂层可以通过定时递送促进胶原形成，成纤维细胞生长和动脉内皮内向内生长的生物修饰剂药物来引起动脉瘤的血栓闭塞。 导管系统可以具有附接的微线圈或可以用MR-可见剂浸渍以允许MR成像系统中的可视化。