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    MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging
    1.
    发明授权
    MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging 有权
    使用非线性磁立体定位的神经系统干预的MR可见医疗装置和方法成像

    公开(公告)号：US06272370B1

    公开(公告)日：2001-08-07

    申请号：US09131031

    申请日：1998-08-07

    申请人： George T. Gillies ,  John Kucharczyk ,  William C. Broaddus ,  Richard Latchaw

    发明人： George T. Gillies ,  John Kucharczyk ,  William C. Broaddus ,  Richard Latchaw

    IPC分类号： A61B505

    CPC分类号： A61M25/0105 ,  A61B2090/3954 ,  A61M25/0127

    摘要： The present invention comprises a device and method for targeted drug delivery, and especially intracranial inflsion or retroperfusion drug delivery using nonlinear magnetic stereotaxis in combination with magnetic resonance (MR) imaging and/or X-ray visualization. An MR-visible and/or X-ray visible drug delivery device is positioned by non-linear magnetic stereotaxis at a site such as an intracranial target site, its location is verified via MR imaging, and it is then used to deliver a biologically active material such as a diagnostic or therapeutic drug solution into that site (such as the brain) at constant or variable rates. The spatial distribution kinetics of the injected or infised drug agent may be monitored quantitatively and non-invasively using real-time MR-imaging such as water proton directional diffusion MR imaging, to establish the efficacy of targeted drug delivery.

    摘要翻译： 本发明包括用于靶向药物递送的装置和方法，特别是使用非线性磁立体定位与磁共振（MR）成像和/或X射线可视化相结合的颅内灌注或后灌注药物递送。 通过非线性磁立体定位在诸如颅内靶位点的位置定位MR可见和/或X射线可见药物递送装置，其位置通过MR成像验证，然后用于递送生物活性 材料，例如以恒定或可变速率进入该部位（例如脑）的诊断或治疗药物溶液。 可以使用实时MR成像（例如水质子定向扩散MR成像）定量和非侵入性地监测注射或致死药物的空间分布动力学，以确定靶向药物递送的功效。

    Coaxial Catheter Systems for Transference of Medium
    6.
    发明申请
    Coaxial Catheter Systems for Transference of Medium 有权
    用于传播介质的同轴导管系统

    公开(公告)号：US20100198137A1

    公开(公告)日：2010-08-05

    申请号：US12760837

    申请日：2010-04-15

    申请人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    发明人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0026 ,  A61M5/007 ,  A61M25/00 ,  A61M25/0045 ,  A61M25/007 ,  A61M27/006 ,  A61M2025/1013

    摘要： A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure.

    摘要翻译： 公开了用于递送治疗剂和/或进入体内的大脑组织和身体其他部位，组织和器官的方法，技术和系统，包括脉管系统。 同轴导管的新颖形式提供了一种用于将外管植入大脑中的装置，然后将内管插入外管并对准它们，使得两个管上的孔口将重叠并允许治疗剂的通量 流入大脑，以尽可能减少被捕获的空气的影响，实际上消除了药剂的回流，并避免了额外的损害大脑的潜力，因为只需要一个手术放置外管。 类似地，该方法技术系统可用于从脑，组织和器官中除去流体或其它介质，以最小化逃逸空气或负压的影响。

    Coaxial catheter systems for transference of medium
    9.
    发明授权
    Coaxial catheter systems for transference of medium 有权
    用于介质转移的同轴导管系统

    公开(公告)号：US07727225B2

    公开(公告)日：2010-06-01

    申请号：US11191676

    申请日：2005-07-28

    申请人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    发明人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    IPC分类号： A61M25/16

    CPC分类号： A61M25/0026 ,  A61M5/007 ,  A61M25/00 ,  A61M25/0045 ,  A61M25/007 ,  A61M27/006 ,  A61M2025/1013

    摘要： A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure.

    摘要翻译： 公开了用于递送治疗剂和/或进入体内的大脑组织和身体其他部位，组织和器官的方法，技术和系统，包括脉管系统。 同轴导管的新颖形式提供了一种用于将外管植入大脑中的装置，然后将内管插入外管并对准它们，使得两个管上的孔口将重叠并允许治疗剂的通量 流入大脑，以尽可能减少被捕获的空气的影响，实际上消除了药剂的回流，并避免了额外的损害大脑的潜力，因为只需要一个手术放置外管。 类似地，该方法技术系统可用于从脑，组织和器官中除去流体或其它介质，以最小化逃逸空气或负压的影响。

    Means and methods for cytometric therapies
    10.
    发明授权
    Means and methods for cytometric therapies 有权
    细胞疗法的方法和方法

    公开(公告)号：US08406837B2

    公开(公告)日：2013-03-26

    申请号：US12513258

    申请日：2007-11-01

    申请人： George T. Gillies ,  Helen Fillmore ,  William C. Broaddus ,  Boyd M. Evans, III ,  Stephen W. Allison

    发明人： George T. Gillies ,  Helen Fillmore ,  William C. Broaddus ,  Boyd M. Evans, III ,  Stephen W. Allison

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075

    摘要： A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.

    摘要翻译： 一个功能化的尖端被并入到导管中，用于将细胞细胞传递到脑和其他身体部位。 为了在脑中使用，尖端形成具有近端和远端的神经外科探针的一部分。 除了功能化的尖端之外，探针具有至少一个细胞浆液递送腔和沿着探针配置的多个光纤，终止于尖端，以提供监测嫁接的生存力和生理行为所需的光学光学能力 细胞以及细胞环境的某些特征。 还提供了在用于调节递送到患者脑部的细胞数量的反馈和控制系统的上下文中使用的具有本发明公开的类型的细胞计数尖端的神经导管的用途的细节。