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    Sustained delivery of PDGF using self-assembling peptide nanofibers
    3.
    发明授权
    Sustained delivery of PDGF using self-assembling peptide nanofibers 失效
    使用自组装肽纳米纤维持续递送PDGF

    公开(公告)号：US07429567B2

    公开(公告)日：2008-09-30

    申请号：US11320468

    申请日：2005-12-29

    申请人： Richard T. Lee ,  Patrick Hsieh

    发明人： Richard T. Lee ,  Patrick Hsieh

    IPC分类号： A61K38/18

    CPC分类号： C07K14/001 ,  A61K38/10 ,  A61K38/1858 ,  A61K47/62 ,  C07K7/08 ,  C07K14/49 ,  A61K2300/00

    摘要： The present invention is directed to a therapeutic composition in which human PDGF is bound directly to peptides that self assemble into a biologically compatible gel. When implanted in a patient's body, the composition provides for the slow, sustained release of PDGF. The composition will be especially useful in treating patients who have undergone a myocardial infarction.

    摘要翻译： 本发明涉及治疗组合物，其中人PDGF直接结合自身组装成生物相容性凝胶的肽。 当植入患者体内时，该组合物提供PDGF的缓慢，持续释放。 该组合物将特别用于治疗已经发生心肌梗塞的患者。

    Targeted delivery of biological factors using self-assembling peptide nanofibers
    4.
    发明授权
    Targeted delivery of biological factors using self-assembling peptide nanofibers 失效
    使用自组装肽纳米纤维靶向递送生物因子

    公开(公告)号：US07399831B2

    公开(公告)日：2008-07-15

    申请号：US11254805

    申请日：2005-10-21

    申请人： Richard T. Lee ,  Michael E. Davis

    发明人： Richard T. Lee ,  Michael E. Davis

    IPC分类号： A61K38/00 ,  C07K17/00

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/001

    摘要： The present invention is directed to methodology that allows a variety of compounds to be attached to self-assembling peptides using biotin/streptavidin linkages. The peptides can be used to form a biologically compatible membrane that promotes the growth and differentiation of cells. The attached therapeutic agents can be used to promote this process and the gel along with the growing cells can be implanted at a site in vivo where tissue repair is needed. Alternatively, membranes can be used for culturing cells in vitro or can be used for delivering drugs in vivo in the absence of seeded cells.

    摘要翻译： 本发明涉及允许使用生物素/链霉抗生物素蛋白键连接多种化合物到自组装肽的方法。 肽可用于形成促进细胞生长和分化的生物相容性膜。 所连接的治疗剂可用于促进该过程，并且随着生长细胞的凝胶可以植入体内需要组织修复的部位。 或者，膜可以用于体外培养细胞，或者可以在没有接种细胞的情况下用于体内递送药物。

    IL-33 in the treatment and diagnosis of diseases and disorders
    5.
    发明授权
    IL-33 in the treatment and diagnosis of diseases and disorders 失效
    IL-33在疾病和病症的治疗和诊断中

    公开(公告)号：US08147817B2

    公开(公告)日：2012-04-03

    申请号：US11800405

    申请日：2007-05-04

    申请人： Richard T. Lee

    发明人： Richard T. Lee

    IPC分类号： A61K38/20 ,  A61K45/00 ,  A61P9/00 ,  C07K14/435

    CPC分类号： A61K45/06 ,  A61K38/20 ,  A61K2039/505 ,  C07K16/244 ,  C07K16/2866 ,  C07K2317/76 ,  C12N15/1135 ,  C12N2310/14 ,  G01N33/566 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2500/20 ,  G01N2510/00 ,  G01N2800/32

    摘要： This invention relates to methods and compositions for the treatment and diagnosis of cardiac diseases and disorders, such as cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis and heart failure. The invention also relates to methods and compositions for the treatment of fibrosis-related diseases as well as methods and compositions for reducing apoptosis, increasing ST2L signaling, decreasing NF-κB activation, decreasing IκBα phosphorylation, decreasing P38MAPK phosphorylation, decreasing JNK phosphorylation, decreasing reactive oxygen species generation, decreasing macrophage infiltration and/or decreasing the expression of hypertrophic genes. More specifically, the invention relates to IL-33 and/or soluble ST2 inhibiting agents for use in the methods and compositions provided.

    摘要翻译： 本发明涉及用于治疗和诊断心脏疾病和病症的方法和组合物，例如心脏肥大，心肌梗塞，中风，动脉硬化和心力衰竭。 本发明还涉及用于治疗纤维化相关疾病的方法和组合物，以及用于减少凋亡，增加ST2L信号传导，减少NF-和κB活化，减少I＆amp;Bα磷酸化，减少P38MAPK磷酸化，降低JNK的方法和组合物 磷酸化，减少活性氧产生，减少巨噬细胞浸润和/或减少增生性基因的表达。 更具体地，本发明涉及用于所提供的方法和组合物中的IL-33和/或可溶性ST2抑制剂。

    COMPOSITIONS OF AND METHODS OF USING LIGAND DIMERS
    6.
    发明申请
    COMPOSITIONS OF AND METHODS OF USING LIGAND DIMERS 有权
    使用配体二聚体的组合物和方法

    公开(公告)号：US20120040900A1

    公开(公告)日：2012-02-16

    申请号：US13120184

    申请日：2009-09-22

    申请人： Luis M. Alvarez ,  Linda G. Griffith ,  Richard T. Lee

    发明人： Luis M. Alvarez ,  Linda G. Griffith ,  Richard T. Lee

    IPC分类号： A61K38/18 ,  C12Q1/02 ,  A61P17/02 ,  A61P35/00 ,  A61P25/00 ,  C12N5/07 ,  C07K14/485

    CPC分类号： A61K38/1808 ,  A61K38/1841 ,  C07K14/475 ,  C07K14/78 ,  C07K2319/70 ,  C07K2319/73 ,  C07K2319/74

    摘要： Provided herein are ligand dimers, compositions thereof, as well as methods of their use. The ligand dimers provided can comprise at least one ligand to a Her receptor and can be used to force dimerization of specific receptor pairs. The forced dimerization of specific receptor pairs can be used to control (e.g., promote or inhibit) signaling, and, therefore, the ligand dimers provided can also be used in various forms of treatment in which such signaling control is beneficial to a subject. It follows that methods for controlling signaling are provided as are various methods of treatment.

    摘要翻译： 本文提供了配体二聚体，其组合物，以及它们的使用方法。 所提供的配体二聚体可以包含至少一种Her受体的配体，并可用于强制特异性受体对的二聚化。 特异性受体对的强制二聚可用于控制（例如，促进或抑制）信号传导，因此，所提供的配体二聚体也可用于各种形式的治疗，其中这种信号传导控制对受试者是有益的。 因此，提供用于控制信号传导的方法是各种治疗方法。

    Aortic valve supporting device
    8.
    发明授权
    Aortic valve supporting device 失效
    主动脉瓣支持装置

    公开(公告)号：US5584879A

    公开(公告)日：1996-12-17

    申请号：US507919

    申请日：1995-07-27

    申请人： Sharon C. Reimold ,  Richard T. Lee ,  Scott D. Solomon

    发明人： Sharon C. Reimold ,  Richard T. Lee ,  Scott D. Solomon

    IPC分类号： A61B17/00 ,  A61F2/24

    CPC分类号： A61F2/2481 ,  A61B2017/00243

    摘要： An aortic valve supporting device having an annular portion located around a central axis with stenting arms extending axially from the annular portion. A hiatus is formed in the annular portion to permit the annular portion and the stenting arms to be positioned around the aorta with the stenting arms in position to apply a supporting force to the aortic valve.

    摘要翻译： 主动脉瓣支撑装置具有围绕中心轴线定位的环形部分，支架臂从环形部分轴向延伸。 在环形部分中形成间隙，以允许环形部分和支架臂定位在主动脉周围，支架臂位于主动脉瓣上施加支撑力。

    PROTEASE RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE
    10.
    发明申请
    PROTEASE RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE 有权
    组织细胞衍生因子-1在组织损伤修复中的抗性突变体

    公开(公告)号：US20100184950A1

    公开(公告)日：2010-07-22

    申请号：US12683253

    申请日：2010-01-06

    申请人： Richard T. Lee ,  Vincent Segers

    发明人： Richard T. Lee ,  Vincent Segers

    IPC分类号： C07K14/435 ,  C07K7/06 ,  C07K7/08

    CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/52 ,  C07K2319/735 ,  C12N5/0652

    摘要： The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.

    摘要翻译： 本发明涉及已被突变的基质细胞来源的因子-1肽，使得它们对蛋白酶二肽基肽酶IV（DPPIV）和基质金属蛋白酶-2（MMP-2）的消化具有抗性，但保持天然SDF- 1吸引T细胞。 突变体可以连接到通过自组装肽形成的膜，然后植入组织损伤部位以帮助促进修复。