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1.Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives 失效
标题翻译: 通过暴露于取代的2-芳基 - 苯并咪唑衍生物治疗瘤形成的方法公开(公告)号:US06211177B1
公开(公告)日:2001-04-03
申请号:US09200378
申请日:1998-11-24
申请人: Gerhard Sperl , Ulrich Ixkes , Rifat Pamukcu , Gary A. Piazza
发明人: Gerhard Sperl , Ulrich Ixkes , Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61K3153
CPC分类号: A61K31/415 , A61K31/44 , A61K31/495 , A61K31/505 , A61K31/53
摘要: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions, by exposing the affected cells to substituted 2-aryl-benzimidazoles.
摘要翻译: 通过将受影响的细胞暴露于取代的2-芳基 - 苯并咪唑来抑制肿瘤形成,特别是癌性和癌前病变的方法。
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2.Method for treating neoplasia by exposure to N,N′-substituted benzimidazol-2-ones 失效
标题翻译: 通过暴露于N,N'-取代的苯并咪唑-2-酮治疗瘤形成的方法公开(公告)号:US06420410B1
公开(公告)日:2002-07-16
申请号:US09639909
申请日:2000-08-16
申请人: Gerhard Sperl , Ulrich Ixkes , Rifat Pamukcu , Gary A. Piazza
发明人: Gerhard Sperl , Ulrich Ixkes , Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61K31415
CPC分类号: A61K31/4184
摘要: A method for inhibiting neoplastic cells and related conditions by exposing them to N,N′-substituted benzimidazol-2-ones.
摘要翻译: 通过将其暴露于N,N'-取代的苯并咪唑-2-酮来抑制肿瘤细胞和相关病症的方法。
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公开(公告)号:US06348032B1
公开(公告)日:2002-02-19
申请号:US09199094
申请日:1998-11-23
申请人: Gerhard Sperl , Rifat Pamukcu , Ulrich Ixkes , Gary A. Piazza
发明人: Gerhard Sperl , Rifat Pamukcu , Ulrich Ixkes , Gary A. Piazza
IPC分类号: A61K3144
CPC分类号: C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/24 , C07D235/26 , C07D235/30 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to benzimidazole derivatives.
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4.[4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia 失效
标题翻译: [4,5] - 三位含硫取代基的3,6-二取代哒嗪用于治疗瘤形成公开(公告)号:US06486158B1
公开(公告)日:2002-11-26
申请号:US09875107
申请日:2001-06-06
申请人: Xiaojing Wang , Gerhard Sperl , Paul Gross , Rifat Pamukcu , Gary A. Piazza
发明人: Xiaojing Wang , Gerhard Sperl , Paul Gross , Rifat Pamukcu , Gary A. Piazza
IPC分类号: C07D47104
CPC分类号: C07D237/30 , C07D237/32
摘要: [4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: wherein Y1 and Y2 are independently selected from the group consisting of (CH2)n,—C(X)—NH—,—(CH2)n—C(X)—O—, and X is O or S; R1 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like; R2 is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like; “A” is a benzene ring fused with the pyridazine ring; and R3 is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.
摘要翻译: [4,5] - 式I的3,6-二取代哒嗪可用于诱导或促进凋亡和阻止不受控制的肿瘤细胞增殖,并且特别可用于阻滞和治疗瘤形成:其中Y 1和Y 2被独立地选择 由(CH 2)n,-C(X)-NH - , - (CH 2)n C(X)-O-,X为O或S组成的组; R 1选自低级烷基,低级 烯基,低级炔基和取代或未取代的苯基,吡啶基等; R2选自取代或未取代的苯基,苄基,吡啶基等;“A”是与哒嗪环稠合的苯环 ; R 3各自独立地选自卤素,低级烷基等。
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5.Substituted benzylidene indenyl formamides, acetamides and propionamides 失效
标题翻译: 取代的亚苄基茚基甲酰胺,乙酰胺和丙酰胺公开(公告)号:US06403831B1
公开(公告)日:2002-06-11
申请号:US09512866
申请日:2000-02-25
申请人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
发明人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
IPC分类号: C07C23542
CPC分类号: A61K31/4409 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/4402 , A61K31/4406
摘要: Substituted benzylidene indenyl formamides, acetamides and propionamides are useful in the treatment of precancerous lesions and neoplasms.
摘要翻译: 取代的亚苄基茚基甲酰胺,乙酰胺和丙酰胺可用于治疗癌前病变和肿瘤。
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公开(公告)号:US6063818A
公开(公告)日:2000-05-16
申请号:US868182
申请日:1997-06-03
申请人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
发明人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61P35/00 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/505 , A61K31/535
CPC分类号: A61K31/4409 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/4402 , A61K31/4406
摘要: Substituted benzylidene indenyl formamides, acetamides and propionamides are useful in the treatment of precancerous lesions and neoplasms.
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7.[4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia 失效
标题翻译: [4,5] - 含氮取代基的1,3-二取代-1,2-二嗪-6-酮衍生物用于治疗瘤形成公开(公告)号:US06180629B2
公开(公告)日:2001-01-30
申请号:US09134425
申请日:1998-08-14
申请人: Xiaojing Wang , Gerhard Sperl , Paul Gross , Rifat Pamukcu , Gary A. Piazza
发明人: Xiaojing Wang , Gerhard Sperl , Paul Gross , Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61K31498
CPC分类号: C07D401/04 , C07D237/32 , C07D401/06 , C07D403/04 , C07D409/04 , C07D409/12 , C07D409/14 , C07D471/04
摘要: [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen-containing substituents in position one are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia, including precancerous and cancerous lesions.
摘要翻译: [4,5] - 位置1中含氮取代基的1,3-二取代-1,2-二嗪-6-酮衍生物可用于诱导或促进凋亡和阻止不受控制的肿瘤细胞增殖,并且是特异性的 可用于阻滞和治疗肿瘤,包括癌前病变和癌变病变。
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8.Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions 失效
标题翻译: 茚基异羟肟酸,(羟基)脲和氨基甲酸酯,用于治疗癌前病变患者公开(公告)号:US06300346B1
公开(公告)日:2001-10-09
申请号:US09520667
申请日:2000-03-07
申请人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
发明人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61K3144
CPC分类号: A61K31/27 , A61K31/16 , A61K31/165 , A61K31/17
摘要: Indenyl hydroxamic acids, (hydroxy) ureas and urethanes are useful in the treatment of precancerous lesions and neoplasms.
摘要翻译: 茚基异羟肟酸,(羟基)脲和氨基甲酸酯可用于治疗癌前病变和赘生物。
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9.Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions 失效
标题翻译: 茚基异羟肟酸,(羟基)脲和氨基甲酸酯,用于治疗癌前病变患者公开(公告)号:US6071934A
公开(公告)日:2000-06-06
申请号:US823863
申请日:1997-03-25
申请人: Gerhard Sperl , Paul Gross , Rifat Pamukcu , Klaus Brendel , Gary A. Piazza
发明人: Gerhard Sperl , Paul Gross , Rifat Pamukcu , Klaus Brendel , Gary A. Piazza
CPC分类号: A61K31/27 , A61K31/16 , A61K31/165 , A61K31/17
摘要: Indenyl hydroxamic acids, (hydroxy) ureas and urethanes are useful in the treatment of precancerous lesions and neoplasms.
摘要翻译: 茚基异羟肟酸,(羟基)脲和氨基甲酸酯可用于治疗癌前病变和赘生物。
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10.Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions 失效
标题翻译: 取代甲氧基亚苄基茚基乙酸和丙酸用于治疗癌前病变患者公开(公告)号:US6121321A
公开(公告)日:2000-09-19
申请号:US661293
申请日:1996-06-13
申请人: Gerhard Sperl , Paul Gross , Klaus Brendel , Gary A. Piazza , Rifat Pamukcu
发明人: Gerhard Sperl , Paul Gross , Klaus Brendel , Gary A. Piazza , Rifat Pamukcu
IPC分类号: A61K31/165 , A61K31/192 , A61K31/216 , A61K31/4402 , A61K31/4406 , A61K31/4409
CPC分类号: A61K31/4409 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/4402 , A61K31/4406
摘要: Substituted methoxy benzylidene indenyl compounds are useful in the treatment of precancerous lesions and neoplasms.
摘要翻译: 取代的甲氧基亚苄基茚基化合物可用于治疗癌前病变和肿瘤。
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