公开(公告)号：US08501115B2

公开(公告)日：2013-08-06

申请号：US12606083

申请日：2009-10-26

申请人： Nils Adey ,  Rob Parry

发明人： Nils Adey ,  Rob Parry

IPC分类号： B01L99/00

CPC分类号： G01N1/312 ,  B01F11/0008 ,  B01F11/0017 ,  B01L3/502715 ,  B01L7/52 ,  B01L2300/1822 ,  G01N35/00029 ,  G01N2001/315 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/00326

摘要： Systems, devices, and methods for automating laboratory protocols utilizing modular processing components to allow systems to be reconfigured for processing a wide variety of disparate laboratory protocols are provided. In one aspect, a sample processing module is provided, including a housing configured to accommodate a pre-identified sample process, a standardized temperature input capable of interfacing with a temperature controller, a standardized fluid input capable of interfacing with an input fluid controller, and a standardized agitation connector capable of interfacing with an agitator. These standardized components provide interchangeability of the module with a module having a housing configured to accommodate a different pre-identified sample process in a sample processing system.

摘要翻译： 提供了使用模块化处理组件自动化实验室协议以允许系统重新配置以处理各种不同实验室协议的系统，设备和方法。 在一个方面，提供了一种样品处理模块，其包括构造成容纳预先识别的样品过程的壳体，能够与温度控制器接口的标准化温度输入，能够与输入流体控制器接口的标准化流体输入，以及 能够与搅拌器连接的标准化搅拌连接器。 这些标准化组件提供了模块与具有壳体的模块的可互换性，该壳体被配置为在样本处理系统中适应不同的预先识别的样本过程。

公开(公告)号：US20110190153A1

公开(公告)日：2011-08-04

申请号：US12997238

申请日：2009-06-09

申请人： Nils Adey ,  Tom Moyer ,  Rob Parry ,  Dale Emery

发明人： Nils Adey ,  Tom Moyer ,  Rob Parry ,  Dale Emery

IPC分类号： C40B30/04 ,  C40B60/12

CPC分类号： C40B30/04 ,  C40B60/12

摘要： A system 300 for the substantially-automated hybridization of a plurality of microarray slides. The system comprises an enclosure 310 with a wash basin 312 having an open top end, a lower carrier rotor 330 disposed within the wash basin on a support axle 318 for receiving a plurality of microarray slide substrates 362, and an upper clamp rotor 340 disposed above the lower carrier rotor on the support axle for receiving a plurality of disposable chamber assemblies 240. The system is further configured so that lowering the upper clamp rotor to engage with the lower carrier rotor couples the plurality of chamber assemblies to the plurality of slide substrates to form a plurality of sealed reaction chambers 244, and raising the upper clamp rotor to disengage from the lower carrier rotor de-couples the plurality of chamber assemblies from the plurality of slide substrates to unseal the plurality of reaction chambers.

摘要翻译： 一种用于多个微阵列载片的基本上自动化杂交的系统300。 该系统包括具有敞开的顶端的洗手盆312的外壳310，设置在洗手盆内的下托架转子330，其位于支撑轴318上，用于容纳多个微阵列滑动基板362，以及设置在上方的上夹具转子340 支撑轴上的下承载转子用于容纳多个一次性室组件240.该系统进一步构造成使得下夹具转子与下承载转子相接合将多个室组件连接到多个滑动衬底上 形成多个密封反应室244，并且升高上夹具转子以与下载体转子脱离，使多个室组件与多个滑动基板脱离接合以开启多个反应室。

公开(公告)号：US20100113288A1

公开(公告)日：2010-05-06

申请号：US12606083

申请日：2009-10-26

申请人： Nils Adey ,  Rob Parry

发明人： Nils Adey ,  Rob Parry

IPC分类号： C40B30/00 ,  G05D9/00 ,  C40B60/00 ,  C12M1/36 ,  C12Q1/68

CPC分类号： G01N1/312 ,  B01F11/0008 ,  B01F11/0017 ,  B01L3/502715 ,  B01L7/52 ,  B01L2300/1822 ,  G01N35/00029 ,  G01N2001/315 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/00326

摘要： Systems, devices, and methods for automating laboratory protocols utilizing modular processing components to allow systems to be reconfigured for processing a wide variety of disparate laboratory protocols are provided. In one aspect, a sample processing module is provided, including a housing configured to accommodate a pre-identified sample process, a standardized temperature input capable of interfacing with a temperature controller, a standardized fluid input capable of interfacing with an input fluid controller, and a standardized agitation connector capable of interfacing with an agitator. These standardized components provide interchangeability of the module with a module having a housing configured to accommodate a different pre-identified sample process in a sample processing system.

摘要翻译： 提供了使用模块化处理组件自动化实验室协议以允许系统重新配置以处理各种不同实验室协议的系统，设备和方法。 在一个方面，提供了一种样品处理模块，其包括构造成容纳预先识别的样品过程的壳体，能够与温度控制器接口的标准化温度输入，能够与输入流体控制器接口的标准化流体输入，以及 能够与搅拌器连接的标准化搅拌连接器。 这些标准化组件提供了模块与具有壳体的模块的可互换性，该壳体被配置为在样本处理系统中适应不同的预先识别的样本过程。

公开(公告)号：US06442161B1

公开(公告)日：2002-08-27

申请号：US09122821

申请日：1998-07-27

申请人： Justin Drummond-Murray ,  David Law ,  Rob Parry

发明人： Justin Drummond-Murray ,  David Law ,  Rob Parry

IPC分类号： H04L1256

CPC分类号： H04L12/4645 ,  H04L1/004

摘要： A network in which a data packet is altered, for instance by the insertion or removal of a data portion such as a VLAN tag. The data of the data packet is read out of memory to an output means which forms the altered data packet with a new FCS portion and to a checking means which checks the integrity of the input packet using the existing FCS. The possibility for discrepancies to occur between the data supplied to the output and checking means is reduced.

摘要翻译： 例如通过插入或移除诸如VLAN标签的数据部分来改变数据分组的网络。 将数据分组的数据从存储器读出到具有新的FCS部分形成改变的数据分组的输出装置以及使用现有的FCS来检查输入分组的完整性的检查装置。 在提供给输出的数据和检查装置的数据之间出现差异的可能性降低。

公开(公告)号：US20130048089A1

公开(公告)日：2013-02-28

申请号：US13695081

申请日：2011-04-29

申请人： Nils B. Adey ,  Rob Parry ,  James Kelland ,  Kevin Sullivan

发明人： Nils B. Adey ,  Rob Parry ,  James Kelland ,  Kevin Sullivan

IPC分类号： G01N1/28 ,  F17D1/00 ,  C40B40/00

摘要： Systems, devices, and methods for automating laboratory protocols utilizing cooperative efforts between differing components including fluidics, agitation and thermal control for processing a wide variety of disparate laboratory protocols are provided. In one aspect, a sample processing module is provided, including a housing configured to accommodate a pre-identified sample process, a temperature input capable of interfacing with a temperature controller, a fluid input capable of interfacing with an input fluid controller, a fluid output capable of interfacing with an output fluid controller, and a standardized agitation connector capable of interfacing with an agitator. A control system interfaces with the temperature input, fluid input, fluid output, and agitation connector to enable the system to perform laboratory protocols that require complex, sequential fluidic steps in association with the temperature and agitation control.

摘要翻译： 提供了使用不同组件之间的协作努力自动化实验室协议的系统，设备和方法，包括用于处理各种不同实验室协议的流体学，搅拌和热控制。 在一个方面，提供了一种样品处理模块，其包括被配置为容纳预先识别的样品过程的壳体，能够与温度控制器接口的温度输入，能够与输入流体控制器接口的流体输入，流体输出 能够与输出流体控制器接口，以及能够与搅拌器接口的标准化搅拌连接器。 控制系统与温度输入，流体输入，流体输出和搅拌连接器接口，使系统能够执行实验室协议，这些实验室协议需要与温度和搅拌控制相关联的复杂的，顺序的流程步骤。

公开(公告)号：US20100167943A1

公开(公告)日：2010-07-01

申请号：US12207343

申请日：2008-09-09

申请人： Nils Adey ,  Tom Moyer ,  Rob Parry ,  Dale Emery

发明人： Nils Adey ,  Tom Moyer ,  Rob Parry ,  Dale Emery

IPC分类号： C40B30/04 ,  C40B60/12

CPC分类号： G01N35/00029 ,  G01N2035/00089 ,  G01N2035/00138

摘要： A system for the automated hybridization of a plurality of microarray slides. The system comprises an enclosure with a wash basin having an open top end, a lower carrier rotor disposed within the wash basin on a support axle for receiving a plurality of microarray slide substrates, and an upper clamp rotor disposed above the lower carrier rotor on the support axle for receiving a plurality of disposable mixers. The system is further configured so that lowering the upper clamp rotor to engage with the lower carrier rotor couples the plurality of mixers to the plurality of slide substrates to form a plurality of sealed reaction chambers, and raising the upper clamp rotor to disengage from the lower carrier rotor de-couples the plurality of mixers from the plurality of slide substrates to unseal the plurality of reaction chambers.

摘要翻译： 用于多个微阵列载玻片的自动杂交的系统。 该系统包括具有开放顶端的洗手盆的外壳，设置在洗手盆内的下托架转子，用于容纳多个微阵列滑动基板的支撑轴上，以及设置在下载架转子上方的上夹具转子 用于接收多个一次性混合器的支撑轴。 该系统进一步被构造成使得下夹具转子与下载体转子相接合将多个混合器耦合到多个滑动基板以形成多个密封的反应室，并且将上夹具转子升高以从下部 载体转子将多个混合器从多个滑动基板解耦，以便打开多个反应室。