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    METHODS AND COMPOSITIONS FOR MODULATING CARBOHYDRATE METABOLISM
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR MODULATING CARBOHYDRATE METABOLISM 有权
    用于调节碳酸盐代谢的方法和组合物

    公开(公告)号：US20070123463A1

    公开(公告)日：2007-05-31

    申请号：US11609810

    申请日：2006-12-12

    申请人： Robert Farese ,  Hubert Chen

    发明人： Robert Farese ,  Hubert Chen

    IPC分类号： A61K38/22

    CPC分类号： G01N33/5088 ,  A61K38/00 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/64 ,  G01N2800/042

    摘要： Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.

    摘要翻译： 提供了调节宿主中碳水化合物代谢的方法和组合物。 在主题方法中，二酰基甘油酰基转移酶（DGAT）活性（特别是DGAT1活性）被调节，例如降低或增强，以达到所需的胰岛素和/或瘦素敏感性，从而调节碳水化合物代谢，例如增加或降低血糖水平， 葡萄糖摄入细胞并同化成糖原。 还提供了用于实践本发明方法的药物组合物。 主题方法和组合物可用于各种应用，包括治疗与异常碳水化合物代谢相关的疾病如肥胖或糖尿病的宿主。

    Mono-and diacylglycerol acyltransferases and methods of use thereof
    2.
    发明申请
    Mono-and diacylglycerol acyltransferases and methods of use thereof 审中-公开
    单酰基甘油和二酰基甘油酰基转移酶及其使用方法

    公开(公告)号：US20050106697A1

    公开(公告)日：2005-05-19

    申请号：US10945738

    申请日：2004-09-20

    申请人： Sylvaine Cases ,  Scot Stone ,  Ping Zhou ,  Robert Farese ,  Chi-Liang Yen

    发明人： Sylvaine Cases ,  Scot Stone ,  Ping Zhou ,  Robert Farese ,  Chi-Liang Yen

    IPC分类号： A61K38/00 ,  C12N9/10 ,  C07H21/04 ,  C12P7/64

    CPC分类号： C12N9/1029 ,  A01K2217/05 ,  A61K38/00 ,  A61K2039/505 ,  C12Y203/0102 ,  C12Y203/01022

    摘要： Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase and/or monoacylglycerol acyltransferase activity, as well as the polypeptide products encoded thereby, i.e., mammalian DGAT2α, MGAT1, or MGAT2 polypeptide products, and methods for producing the same, are provided. Also provided are: methods and compositions for modulating DGAT2α, MGAT1, or MGAT2 activity; DGAT2α, MGAT1, or MGAT2 transgenic cells, animals and plants, as well as methods for their preparation; and methods for making diglyceride, diglyceride compositions, triglycerides and triglyceride compositions, as well as the compositions produced by these methods. The subject methods and compositions find use in a variety of different applications, including research, medicine, agriculture and industry applications.

    摘要翻译： 提供了编码具有甘油二酯酰基转移酶和/或单酰基甘油酰基转移酶活性的多肽产物的核酸组合物，以及由此编码的多肽产物，即哺乳动物DGAT2α，MGAT1或MGAT2多肽产物及其制备方法。 还提供了：用于调节DGAT2α，MGAT1或MGAT2活性的方法和组合物; DGAT2α，MGAT1或MGAT2转基因细胞，动物和植物，以及它们的制备方法; 以及制备甘油二酯，甘油二酯组合物，甘油三酯和甘油三酯组合物的方法以及通过这些方法制备的组合物。 主题方法和组合物可用于各种不同的应用，包括研究，医学，农业和工业应用。