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公开(公告)号：US08246978B2
公开(公告)日：2012-08-21
申请号：US12668322
申请日：2008-07-10
CPC分类号： A61K9/7061 , A61F2013/00646 , A61K9/7084 , A61K31/566 , A61K31/567 , A61K31/568 , A61K31/573 , A61K47/14 , A61K47/20
摘要： This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the AI layer having a perimeter that extends beyond the perimeter of the AI layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the AI layer having a perimeter of which extends beyond the perimeter of the AI layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the AI layer to form a seal that reduces or prevents volatile component loss.
摘要翻译： 本发明涉及一种透皮药物递送装置，其包含活性成分（AI）层，其具有皮肤接触表面和非皮肤接触表面，并且包含挥发性成分，不透过皮肤接触表面的挥发性组分的剥离衬垫 的AI层具有在所有方向上延伸超过AI层的周边的周边，以及覆盖层，其包含不吸收与AI层的非皮肤接触表面相邻的挥发性组分的压敏粘合剂（PSA），所述粘合剂 其周边在所有方向上延伸超出AI层的周边，其中覆盖层的剥离衬垫和PSA与AI层的周边相互接触并且彼此粘附以形成密封，以减少或防止 挥发性成分损失。
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公开(公告)号：US20130018337A1
公开(公告)日：2013-01-17
申请号：US13553362
申请日：2012-07-19
IPC分类号： A61M35/00
CPC分类号： A61K9/7061 , A61F2013/00646 , A61K9/7084 , A61K31/566 , A61K31/567 , A61K31/568 , A61K31/573 , A61K47/14 , A61K47/20
摘要： This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the Al layer having a perimeter that extends beyond the perimeter of the AI layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a perimeter of which extends beyond the perimeter of the Al layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the Al layer to form a seal that reduces or prevents volatile component loss.
摘要翻译： 本发明涉及一种透皮药物递送装置，其包含活性成分（AI）层，其具有皮肤接触表面和非皮肤接触表面，并且包含挥发性成分，不透过皮肤接触表面的挥发性组分的剥离衬垫 的Al层具有在所有方向上延伸超过AI层的周边的周边，以及覆盖层，其包含不吸收与Al层的非皮肤接触表面相邻的挥发性组分的压敏粘合剂（PSA），所述粘合剂 其周边在所有方向上延伸超出Al层的周边，其中覆盖层的剥离衬垫和PSA与Al层的周边彼此接触并彼此粘附以形成密封，以减少或防止 挥发性成分损失。
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公开(公告)号：US20100255072A1
公开(公告)日：2010-10-07
申请号：US12668322
申请日：2008-07-10
CPC分类号： A61K9/7061 , A61F2013/00646 , A61K9/7084 , A61K31/566 , A61K31/567 , A61K31/568 , A61K31/573 , A61K47/14 , A61K47/20
摘要： This invention relates to a transdermal drug delivery device that comprises an active ingredient (Al) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the Al layer having a peπmeter that extends beyond the perimeter of the Al layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a peπmeter of which extends beyond the penmeter of the Al layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the peπmeter of the Al layer to form a seal that reduces or prevents volatile component loss.
摘要翻译： 本发明涉及一种透皮药物递送装置，其包含活性成分（Al）层，其具有皮肤接触表面和非皮肤接触表面，并且包含挥发性成分，不透过与皮肤接触表面相邻的挥发性组分的剥离衬垫 的Al层具有在所有方向上延伸超出Al层的周边的测量仪，以及覆盖层，其包含不吸收邻近Al的非皮肤接触表面的挥发性组分的压敏粘合剂（PSA） 层具有在所有方向上延伸超过Al层的测厚仪的层厚度，其中所述覆盖层的剥离衬垫和PSA与Al层的测量仪彼此接触并彼此粘附以形成 减少或防止挥发性成分损失的密封件。
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公开(公告)号：US20120215186A1
公开(公告)日：2012-08-23
申请号：US13463494
申请日：2012-05-03
IPC分类号： A61M35/00
CPC分类号： A61K9/7084 , A61K9/7061 , A61K31/56 , A61K31/57 , A61K2300/00
摘要： A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%.
摘要翻译： 公开了一种透皮药物递送装置。 在延长的磨损期间，该装置导致累积的中度刺激加上显着的刺激小于5％和/或在小于20％的七天期间达到有意义的脱离程度。
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公开(公告)号：US20100178323A1
公开(公告)日：2010-07-15
申请号：US12687489
申请日：2010-01-14
CPC分类号： A61K9/7084 , A61K9/7061 , A61K31/56 , A61K31/57 , A61K2300/00
摘要： A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%.
摘要翻译： 公开了一种透皮药物递送装置。 在延长的磨损期间，该装置导致累积的中度刺激加上显着的刺激小于5％和/或在小于20％的七天期间达到有意义的脱离程度。
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公开(公告)号：US09050348B2
公开(公告)日：2015-06-09
申请号：US13463494
申请日：2012-05-03
CPC分类号： A61K9/7084 , A61K9/7061 , A61K31/56 , A61K31/57 , A61K2300/00
摘要： A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%.
摘要翻译： 公开了一种透皮药物递送装置。 在延长的磨损期间，该装置导致累积的中度刺激加上显着的刺激小于5％和/或在小于20％的七天期间达到有意义的脱离程度。
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公开(公告)号：US08747888B2
公开(公告)日：2014-06-10
申请号：US13553362
申请日：2012-07-19
CPC分类号： A61K9/7061 , A61F2013/00646 , A61K9/7084 , A61K31/566 , A61K31/567 , A61K31/568 , A61K31/573 , A61K47/14 , A61K47/20
摘要： This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the AI layer having a perimeter that extends beyond the perimeter of the AI layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a perimeter of which extends beyond the perimeter of the AI layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the AI layer to form a seal that reduces or prevents volatile component loss.
摘要翻译： 本发明涉及一种透皮药物递送装置，其包含活性成分（AI）层，其具有皮肤接触表面和非皮肤接触表面，并且包含挥发性成分，不透过与皮肤接触表面相邻的挥发性成分的剥离衬垫 的AI层具有在所有方向上延伸超出AI层的周边的周边，以及覆盖层，其包含不吸收与Al层的非皮肤接触表面相邻的挥发性组分的压敏粘合剂（PSA），所述粘合剂 其周边在所有方向上延伸超出AI层的周边，其中覆盖层的剥离衬垫和PSA与AI层的周边相互接触并且彼此粘附以形成密封，以减少或防止 挥发性成分损失。
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