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1.发明授权公开(公告)号：US08148679B2
公开(公告)日：2012-04-03
申请号：US12513944
申请日：2007-11-07
IPC分类号： H01J37/301 , H01J49/04 , H01J49/24 , H01J3/18
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译： 用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。 导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流 到导管60的侧壁外侧的较低压力区域。
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公开(公告)号：US07351961B2
公开(公告)日：2008-04-01
申请号：US10573194
申请日：2004-09-24
申请人： Robert Malek , Frank Czemper
发明人： Robert Malek , Frank Czemper
IPC分类号： B01D59/44
CPC分类号： H01J49/38
摘要： This invention relates to a measuring cell for an Ion Cyclotron Resonance (ICR) spectrometer. The present invention provides a measurement cell for an FTMS spectrometer, comprising an excitation electrode arrangement positioned about a longitudinal axis which extends in a direction generally parallel to the field direction of an applied homogeneous magnetic field; and a trapping electrode arrangement, also positioned about the said longitudinal axis, for trapping ions longitudinally in the cell within a trapping region defined by the trapping electrode arrangement; wherein at least a part of the excitation electrode arrangement extends axially outwardly of the trapping region defined by the trapping electrode arrangement.
摘要翻译： 本发明涉及用于离子回旋共振（ICR）光谱仪的测量池。 本发明提供了一种用于FTMS光谱仪的测量单元，包括围绕纵向轴线定位的激励电极装置，所述纵向轴线在大致平行于所施加的均匀磁场的场方向的方向上延伸; 以及围绕所述纵向轴线定位的捕获电极装置，用于在由所述捕获电极装置限定的捕获区域内在所述电池中纵向俘获离子; 其中所述激励电极装置的至少一部分沿着由所述捕获电极装置限定的所述捕获区域轴向向外延伸。
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公开(公告)号：US20070040114A1
公开(公告)日：2007-02-22
申请号：US10573194
申请日：2004-09-24
申请人： Robert Malek , Frank Czemper
发明人： Robert Malek , Frank Czemper
IPC分类号： B01D59/44
CPC分类号： H01J49/38
摘要： This invention relates to a measuring cell for an Ion Cyclotron Resonance (ICR) spectrometer. The present invention provides a measurement cell for an FTMS spectrometer, comprising an excitation electrode arrangement positioned about a longitudinal axis which extends in a direction generally parallel to the field direction of an applied homogeneous magnetic field; and a trapping electrode arrangement, also positioned about the said longitudinal axis, for trapping ions longitudinally in the cell within a trapping region defined by the trapping electrode arrangement; wherein at least a part of the excitation electrode arrangement extends axially outwardly of the trapping region defined by the trapping electrode arrangement.
摘要翻译： 本发明涉及用于离子回旋共振（ICR）光谱仪的测量池。 本发明提供了一种用于FTMS光谱仪的测量单元，包括围绕纵向轴线定位的激励电极装置，所述纵向轴线在大致平行于所施加的均匀磁场的场方向的方向上延伸; 以及围绕所述纵向轴线定位的捕获电极装置，用于在由所述捕获电极装置限定的捕获区域内在所述电池中纵向俘获离子; 其中所述激励电极装置的至少一部分沿着由所述捕获电极装置限定的所述捕获区域轴向向外延伸。
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4.发明授权公开(公告)号：US08642949B2
公开(公告)日：2014-02-04
申请号：US13413568
申请日：2012-03-06
IPC分类号： H01J37/301 , H01J49/04 , H01J49/24 , H01J3/18
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译： 用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。 导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流 到导管60的侧壁外侧的较低压力区域。
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公开(公告)号：US07982183B2
公开(公告)日：2011-07-19
申请号：US12513939
申请日：2007-11-07
IPC分类号： H01J49/24 , H01J49/04 , H01J3/18 , H01J37/301
CPC分类号： H01J49/065
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of a mass spectrometer includes an electrode assembly (120) with a first plurality of ring electrodes (205) arranged in alternating relation with a second plurality of ring electrodes (210). The first plurality of ring electrodes (205) are narrower than the second plurality of ring electrodes (210) in a longitudinal direction, but the first plurality of ring electrodes have a relatively high magnitude voltage of a first polarity applied to them whereas the second plurality of ring electrodes (210) have a relatively lower magnitude voltage applied to them, of opposing polarity to that applied to the first set of ring electrodes (205). In this manner, ions passing through the ion transfer arrangement experience spatially alternating asymmetric electric fields that tend to focus ions away from the inner surface of the channel wall and towards the channel plane or axis of symmetry.
摘要翻译： 用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括具有与第二多个环形电极（210）交替设置的第一多个环形电极（205）的电极组件（120）。 第一多个环形电极（205）在纵向方向上比第二多个环形电极（210）窄，但是第一多个环形电极具有施加到它们的第一极性的相对高的幅度电压，而第二个多个环形电极 环形电极（210）具有相对于施加到第一组环形电极（205）的相反极性的相对较低的施加到它们的幅度电压。 以这种方式，通过离子转移装置的离子经历空间交替的不对称电场，其倾向于将离子聚焦离开通道壁的内表面并朝向通道平面或对称轴线。
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公开(公告)号：US07962301B2
公开(公告)日：2011-06-14
申请号：US12639914
申请日：2009-12-16
申请人： Robert Malek , Oliver Lange
发明人： Robert Malek , Oliver Lange
IPC分类号： G06F17/00
CPC分类号： H01J49/0036 , H03M7/30
摘要： A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data.
摘要翻译： 公开了用于傅立叶变换质谱（FTMS）的数据压缩技术。 对频域中的数据进行统计分析，因为这些数据大部分是随机分布的电子噪声的结果。 将整个频率数据集合到分布上进行确定分布的初步时刻。 然后删除该分布尾部的数据（主要是峰值数据），并将剩余的数据点重新拟合到分布中，以识别该剩余噪声数据的分布时刻。 然后使用计算的时刻应用质谱的噪声阈值。 保持阈值以上的数据。 可以通过将分布的时刻与峰值数据一起存储，然后从那些时刻再生噪声并将其加到峰值数据来重构整个频谱。
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公开(公告)号：US20070203652A1
公开(公告)日：2007-08-30
申请号：US10592745
申请日：2005-03-24
申请人： Stevan Horning , Oliver Lange , Robert Malek , Andreas Wieghaus
发明人： Stevan Horning , Oliver Lange , Robert Malek , Andreas Wieghaus
IPC分类号： G06F19/00
CPC分类号： H01J49/38 , H01J49/0009
摘要： The present invention provides a method of improving a mass spectrum collected from a mass spectrometer comprising a detector for collecting a mass spectrum from ions stored in or released from an ion trapping volume, wherein assignment of masses to peaks appearing in the mass spectrum is sensitive to an experimental parameter related to the mass spectrometer or the operation thereof, such as ion abundance, the method comprising: determining a positional value of a peak; determining the experimental parameter associated with the mass spectrum; comparing the determined positional value with positional values of peaks contained in a calibration dataset; and improving the determined positional value of the peak from adjacent peak positional values by interpolation thereby to provide a corrected mass assignment for the peak. The present invention also provides a method of calibrating such a mass spectrometer.
摘要翻译： 本发明提供了一种改进从质谱仪收集的质谱的方法，该质谱仪包括用于从离子捕获体积存储或释放的离子中收集质谱的检测器，其中质谱对质谱中出现的峰的分配对 与质谱仪或其操作相关的实验参数，例如离子丰度，该方法包括：确定峰的位置值; 确定与质谱相关的实验参数; 将确定的位置值与校准数据集中包含的峰的位置值进行比较; 并且通过插值从相邻的峰值位置值改善确定的峰值的位置值，从而为峰值提供校正的质量分配。 本发明还提供了一种校准这种质谱仪的方法。
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公开(公告)号：US20070143319A1
公开(公告)日：2007-06-21
申请号：US10573395
申请日：2004-09-23
申请人： Robert Malek , Oliver Lange
发明人： Robert Malek , Oliver Lange
IPC分类号： G06F7/00
CPC分类号： H01J49/0036 , H03M7/30
摘要： A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data
摘要翻译： 公开了用于傅立叶变换质谱（FTMS）的数据压缩技术。 对频域中的数据进行统计分析，因为这些数据大部分是随机分布的电子噪声的结果。 将整个频率数据集合到分布上进行确定分布的初步时刻。 然后删除该分布尾部的数据（主要是峰值数据），并将剩余的数据点重新拟合到分布中，以识别该剩余噪声数据的分布时刻。 然后使用计算的时刻应用质谱的噪声阈值。 保持阈值以上的数据。 可以通过将分布的时刻与峰值数据一起存储，然后从那些时刻再生噪声并将其加到峰值数据中来重构整个频谱
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公开(公告)号：US20220121814A1
公开(公告)日：2022-04-21
申请号：US17478948
申请日：2021-09-19
申请人： Mark Rosno , Patrick Deziel , Christopher Korzenowski , Rebecca Bilbro , Kelsey L. Bruso , Robert Malek
发明人： Mark Rosno , Patrick Deziel , Christopher Korzenowski , Rebecca Bilbro , Kelsey L. Bruso , Robert Malek
IPC分类号： G06F40/205 , G06F16/93 , G06F16/245
摘要： A method of parsing implicit tables within a document includes parsing, by a processor, a document to determine a pattern for a set of text that sets apart the information contained therein from the rest of the text; determining, by the processor, from the pattern of spacing, a first descriptive phrase and a second descriptive phrase; and assigning, by the processor, the first descriptive phrase as an action and the second descriptive phrase as a trigger.
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公开(公告)号：US20220121666A1
公开(公告)日：2022-04-21
申请号：US17478947
申请日：2021-09-19
申请人： Mark Rosno , Patrick Deziel , Christopher Korzenowski , Rebecca Bilbro , Kelsey L. Bruso , Robert Malek
发明人： Mark Rosno , Patrick Deziel , Christopher Korzenowski , Rebecca Bilbro , Kelsey L. Bruso , Robert Malek
IPC分类号： G06F16/2453 , G06F16/2457 , G06F16/93 , G06N3/08 , G06F40/40
摘要： A method of creating a trained database from a document corpus includes creating a tailored neural network for the document corpus by using sentences to create word-level association and sentence-level association; and applying action-trigger phrase sets, created front the document corpus independent of creating the tailored neural network, to the tailored neural network to create a trained database; wherein processing a query through the trained database, rather than the document corpus, increases the speed of processing the query and increases the accuracy of the result.
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