公开(公告)号：US11680938B2

公开(公告)日：2023-06-20

申请号：US16446871

申请日：2019-06-20

Applicant: Saudi Arabian Oil Company

Inventor： Hendrik Muller ,  Nadrah Abdullah Alawani ,  Ibrahim E. Al-Naimi

IPC: G01N33/28 ,  G01N33/24 ,  H01J49/00 ,  H01J49/38 ,  H01J49/40

CPC classification number: G01N33/2823 ,  G01N33/241 ,  G01N33/287 ,  H01J49/004 ,  H01J49/38 ,  H01J49/40

Abstract: A method and system to determine mass fraction of aromatic hydrocarbons, sulfur-multi-sulfur, sulfur-nitrogen, multi-sulfur-multi-nitrogen, and nitrogen containing aromatic compound classes present within a petroleum sample. The invention uses total sulfur determination, total nitrogen determination, and elemental formulas determination, with the latter determined through time-of-flight mass spectrometric analysis with atmospheric pressure photo ionization and Fourier-transform ion-cyclotron resonance mass spectrometric analysis with atmospheric pressure photo ionization.

公开(公告)号：US20180323052A1

公开(公告)日：2018-11-08

申请号：US15773720

申请日：2016-11-24

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Takashi Baba

IPC: H01J49/42 ,  H01J49/38

CPC classification number: H01J49/4255 ,  H01J49/38 ,  H01J49/424

Abstract: Improvements to a side-on Penning trap include a feedback system for stabilizing the magnetic field. This system includes a magnetic sensor that measures the magnetic field and a solenoid coil that in response to the magnetic field measurements increases or decreases the overall magnetic field. Improvements also include a number of different configurations of the two sets of PCB electrodes used to produce the quadrupole electric field. Dimensions of the PCB electrodes are optimized, an equipotential surface electrode is added, and additional ring electrodes are added to produce a purer quadrupole field. A central disk electrode is segmented to direct charged particles to the trap center to make the trap useful for applications other than mass spectrometry. Finally, outer ring electrodes are segmented to increase the path of charged particles, thereby increasing sensitivity.

公开(公告)号：US20180068842A1

公开(公告)日：2018-03-08

申请号：US15795405

申请日：2017-10-27

Applicant: Carl Zeiss SMT GmbH

Inventor： Michel Aliman ,  Alexander Laue ,  Hin Yiu Anthony Chung ,  Gennady Fedosenko ,  Ruediger Reuter ,  Leonid Gorkhover ,  Martin Antoni ,  Andreas Gorus ,  Valerie Derpmann

IPC: H01J49/38 ,  H01J49/42 ,  H01J49/00

CPC classification number: H01J49/38 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/425 ,  H01J49/426 ,  H01J49/427 ,  H01J49/4295

Abstract: A method for examining a gas by mass spectrometry includes: ionizing the gas for producing ions; and storing, exciting and detecting at least some of the produced ions in an FT ion trap. Producing and storing the ions in the FT ion trap and/or exciting the ions prior to the detection of the ions in the FT ion trap includes at least one selective IFT excitation, such as a SWIFT excitation, which is dependent on the mass-to-charge ratio of the ions. The disclosure further relates to a mass spectrometer. A mass spectrometer includes: an FT ion trap; and an excitation device for storing, exciting, and detecting ions in the FT ion trap.

公开(公告)号：US09786483B2

公开(公告)日：2017-10-10

申请号：US14787081

申请日：2014-04-24

Applicant: FOM INSTITUTE FOR ATOMIC AND MOLECULAR PHYSICS

Inventor： Ronald Martinus Alexander Heeren ,  Julia Helga Jungmann ,  Don Smith

IPC: H01J49/38 ,  H01J49/02 ,  H01J49/06 ,  H01J49/40 ,  H05K1/02

CPC classification number: H01J49/38 ,  H01J49/025 ,  H01J49/06 ,  H01J49/40 ,  H05K1/0206 ,  H05K2201/0195

Abstract: An ion trap such as an ion cyclotron resonance analyzer cell (trap) is described wherein the ion trap comprises a plurality of electrodes and has at least one integrated ion detector, preferably a position-sensitive and/or time-sensitive ion detector, wherein at least part of said ion detector is configured as an electrode of said ion trap. Methods of position-sensitive detection of ions in such ion trap are described as well.

公开(公告)号：US09520280B2

公开(公告)日：2016-12-13

申请号：US13993316

申请日：2011-12-14

Applicant: Alexander A. Makarov

Inventor： Alexander A. Makarov

IPC: H01J49/00 ,  H01J49/28 ,  H01J49/02 ,  H01J49/38 ,  H01J49/42

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

公开(公告)号：US09299546B2

公开(公告)日：2016-03-29

申请号：US14305676

申请日：2014-06-16

Applicant: Bruker Daltonik GmbH

Inventor： Evgeny Nikolaev

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/36 ,  H01J49/42

CPC classification number: H01J49/0036 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/36 ,  H01J49/38 ,  H01J49/425

Abstract: The invention provides a method for acquiring a mass spectrum with a Fourier transform mass spectrometer, wherein analyte ions and additional reporter ions oscillate at mass specific frequencies in a measuring cell of the frequency mass spectrometer and interact by Coulomb forces; the image current signal induced by the reporter ion is measured; and mass signals of the analyte ions are determined from a sideband signal of the reporter ions in the frequency domain or from the instantaneous frequency of the reporter ions in the time domain.

Abstract translation: 本发明提供了一种利用傅里叶变换质谱仪获取质谱的方法，其中分析物离子和附加的报道离子在质谱特定频率上在频率质谱仪的测量单元中振荡并与库仑力相互作用; 测量报告离子诱导的图像电流信号; 并且分析物离子的质量信号由频域中的报道离子的边带信号或时域中报道离子的瞬时频率确定。

公开(公告)号：US20150325424A1

公开(公告)日：2015-11-12

申请号：US14686012

申请日：2015-04-14

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Konstantin AIZIKOV ,  Dirk NOLTING

IPC: H01J49/24 ,  H01J49/42 ,  G01L21/30

CPC classification number: H01J49/24 ,  G01L21/30 ,  H01J49/38 ,  H01J49/425 ,  H01J49/4265

Abstract: A method is proposed for assessing the vacuum conditions in a mass spectrometer (10) such as an ion cyclotron resonance or orbital trapping mass spectrometer. Such mass spectrometers generate a transient detection signal resulting from ions of one or species in an ion trap (80). The parameters of the trap and/or introduced ions are adjusted so as to cause the decay rate of the transient in respect of the ion species to be dominated by collisional effects. Typically this can be achieved by introducing ions into the trap (80) in quantities such that ion clouds of a particular ion species self bunch. The rate of decay of the transient signal in that case is determined and compared with one or more threshold decay rates. This in turn can provide an indication of vacuum conditions within the trap (80).

Abstract translation: 提出了一种用于评估质谱仪（10）如离子回旋共振或轨道捕获质谱仪中的真空条件的方法。 这种质谱仪产生由离子阱（80）中的一个或多个物质的离子产生的瞬态检测信号。 调节陷阱和/或引入的离子的参数，以使离子种类的瞬变的衰减速率由碰撞效应来支配。 通常，这可以通过将离子引入捕集器（80）中以使得特定离子物质的离子云自发束的量来实现。 在这种情况下，确定瞬态信号的衰减速率并将其与一个或多个阈值衰减速率进行比较。 这又可以提供陷阱（80）内的真空条件的指示。

公开(公告)号：US09111735B1

公开(公告)日：2015-08-18

申请号：US13753685

申请日：2013-01-30

Applicant: Eugene N. Nikolaev ,  Roland Jertz ,  Anton S. Grigoryev ,  Gökhan Baykut

Inventor： Eugene N. Nikolaev ,  Roland Jertz ,  Anton S. Grigoryev ,  Gökhan Baykut

IPC: H01J49/00

CPC classification number: H01J49/0036 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/38 ,  H01J49/425 ,  H01J2237/223

Abstract: Fine structures of isotopic peak clusters of substances are determined using ultrahigh resolution mass spectrometry, e.g, FT-ICR mass spectrometry. Resolved individual peaks in the fine structure of the non-monoisotopic peak clusters of organic substances usually contain the additional elemental isotopes 13C, 15N, 17O, 18O, 2H, 33S, 34S, and combinations thereof. In each of a series of experiments, one of the non-monoisotopic peak clusters is isolated and the corresponding fine structure spectrum acquired. Abundances of the resolved fine structure peaks and their positions on the mass scale are recorded and, after measuring some or all of the isotopic peaks, the atomic composition of the measured substance is calculated. By excluding the monoisotopic peak and isolating only one isotopic peak cluster at a time, the number of ions in the FT-ICR cell is kept low, which avoids resolving power losses due to space charge effects and ion-ion interaction phenomena.

Abstract translation: 使用超高分辨率质谱法，例如FT-ICR质谱法测定物质的同位素峰簇的精细结构。 有机物质的非单同位素峰簇的精细结构中分解的单个峰通常含有另外的元素同位素13C，15N，17O，18O，2H，33S，34S及其组合。 在一系列实验的每一个实验中，非单同位素峰簇之一被隔离，并获得相应的精细结构谱。 记录解析的精细结构峰的丰度及其在质量尺度上的位置，并测量部分或全部同位素峰后，计算被测物质的原子组成。 通过排除单同位素峰并一次隔离一个同位素峰簇，FT-ICR单元中的离子数保持较低，避免了由于空间电荷效应和离子 - 离子相互作用现象而分解功率损耗。

公开(公告)号：US08975581B2

公开(公告)日：2015-03-10

申请号：US14346007

申请日：2012-09-20

Applicant: The University of Sussex

Inventor： Jose Luis Verdu Galiana

IPC: H01J49/20 ,  H01J49/00

CPC classification number: H01J49/20 ,  B82Y10/00 ,  H01J49/0018 ,  H01J49/0031 ,  H01J49/38 ,  H01J49/422

Abstract: An ion trap comprising: a first array of magnetic elements arranged to generate a first magnetic field with a degree of homogeneity; and an array of electrodes arranged to generate an electrostatic field including a turning point in electrical potential at a location where the magnetic field has a substantially maximum degree of homogeneity; wherein the array of electrodes is planar and parallel to the direction of the magnetic field at the location; and wherein a primary first magnetic element is arranged to generate a first component of the first magnetic field and other first magnetic elements are arranged to generate compensating components of the first magnetic field that reduce the gradient, the curvature and higher order derivatives of the first component of the first magnetic field at the location where the first magnetic field has the substantially maximum degree of homogeneity.

Abstract translation: 一种离子阱，包括：第一磁性元件阵列，被布置成产生具有均匀度的第一磁场; 以及布置成产生静电场的电极阵列，其包括在磁场具有基本上最大程度的均匀性的位置处的电位的转折点; 其中所述电极阵列是平面的并且平行于所述位置处的所述磁场的方向; 并且其中主要第一磁性元件被布置成产生第一磁场的第一分量，并且其他第一磁性元件被布置成产生第一磁场的补偿分量，其减小第一分量的梯度，曲率和高阶导数 在第一磁场具有基本上最大程度的均匀性的位置处的第一磁场。

公开(公告)号：US08825413B2

公开(公告)日：2014-09-02

申请号：US12755977

申请日：2010-04-07

Applicant: Alexander Misharin ,  Konstantin Novoselov ,  Vladimir M. Doroshenko

Inventor： Alexander Misharin ,  Konstantin Novoselov ,  Vladimir M. Doroshenko

IPC: G01N31/00 ,  H01J49/38 ,  H01J49/00 ,  H03F1/26

CPC classification number: H01J49/0036 ,  H01J49/38

Abstract: A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions. The method and system derive calculated amplitudes of the overtone frequency peaks associated with the groups of ions by incorporating measured amplitudes of the frequency peaks related to the subharmonic frequency, the higher harmonic frequency, or the side-shifted frequency associated with the groups of ions into the calculated amplitudes of the overtone frequency peaks. The method and system generate a deconvoluted frequency spectrum including the overtone frequency peaks associated with the different groups of ions.

Abstract translation: 基于对M阶离子振荡泛音（其中整数M> 1）的检测，在ICR质谱仪中获得的频谱的去卷积方法和系统。 在分别对应于不同离子组的振荡的频谱内收集多个频率峰值，并且将具有频率f和测量幅度A的频率峰值中的至少一个与特定的一组离子相关联。 该方法和系统识别频率峰值是否与不同离子组的振荡的泛音频率，次谐波频率，高次谐波频率或侧移频率之一相关。 该方法和系统通过将与次谐波频率，高次谐波频率或与离子组相关联的侧移频率相关的频率峰值的测量幅度并入到离子组相关的泛音频率峰值中来计算振幅 计算的泛音频率峰值的幅度。 该方法和系统产生包括与不同离子组相关的泛音频率峰值的解卷积频谱。