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    Myocardial revascularization
    3.
    发明授权
    Myocardial revascularization 失效

    公开(公告)号：US06592576B2

    公开(公告)日：2003-07-15

    申请号：US09867349

    申请日：2001-05-29

    申请人： Robert R. Andrews ,  Robert I. Rudko ,  Richard P. Yeomans, Jr. ,  Italo J. DeSantis ,  Weslaw Gronek

    发明人： Robert R. Andrews ,  Robert I. Rudko ,  Richard P. Yeomans, Jr. ,  Italo J. DeSantis ,  Weslaw Gronek

    IPC分类号： A61B1818

    CPC分类号： A61B18/24 ,  A61B2017/00243

    摘要： A myocardial revascularization system that includes a laser energy source (e.g., a semiconductor laser), an outer guide member providing access to a patient's heart, and an optical fiber. The optical fiber is coupled to receive laser energy pulses from the source, is slidably located within the guide member, and is extendible from the distal end of the guide member. A drive motor is connected to the fiber to automatically move the distal end of the optical fiber with respect to the distal end of the guide member. A controller controls the drive motor to automatically move the fiber in synchronism with firing of the laser energy, and automatically calibrates the position of the distal end of the fiber with respect to the distal end of the catheter. The fiber has, at its tip, an enlargened portion with a front surface coated with a heat absorbing material that is nonmetallic and is partially transparent to the pulses. The outer guide member is 7 French or smaller and has a deflectable distal end. A lubricant is located between the optical fiber and an inner lumen surface of the guide member and on the outer surface of the outer guide member. Position sensing components are carried by the optical fiber and outer guide member at or near their distal ends.

    Myocardial revascularization
    4.
    发明授权
    Myocardial revascularization 失效
    心肌血运重建

    公开(公告)号：US06464693B1

    公开(公告)日：2002-10-15

    申请号：US09519502

    申请日：2000-03-06

    申请人： Robert R. Andrews ,  Robert I. Rudko ,  Richard P. Yeomans, Jr. ,  Italo J. DeSantis ,  Weslaw Gronek

    发明人： Robert R. Andrews ,  Robert I. Rudko ,  Richard P. Yeomans, Jr. ,  Italo J. DeSantis ,  Weslaw Gronek

    IPC分类号： A61B1818

    CPC分类号： A61B18/24 ,  A61B2017/00243

    摘要： A myocardial revascularization system that includes a laser energy source (e.g., a semiconductor laser), an outer guide member providing access to a patient's heart, and an optical fiber. The optical fiber is coupled to receive laser energy pulses from the source, is slidably located within the guide member, and is extendible from the distal end of the guide member. A drive motor is connected to the fiber to automatically move the distal end of the optical fiber with respect to the distal end of the guide member. A controller controls the drive motor to automatically move the fiber in synchronism with firing of the laser energy, and automatically calibrates the position of the distal end of the fiber with respect to the distal end of the catheter. The fiber has, at its tip, an enlargened portion with a front surface coated with a heat absorbing material that is nonmetallic and is partially transparent to the pulses. The outer guide member is 7 French or smaller and has a deflectable distal end. A lubricant is located between the optical fiber and an inner lumen surface of the guide member and on the outer surface of the outer guide member. Position sensing components are carried by the optical fiber and outer guide member at or near their distal ends.

    摘要翻译： 包括激光能量源（例如，半导体激光器），提供对患者心脏的通路的外部引导构件和光纤的心肌血运重建系统。 光纤被耦合以从源接收激光能量脉冲，可滑动地位于引导构件内，并且可从引导构件的远端延伸。 驱动电动机连接到光纤上以相对于导向件的远端自动移动光纤的远端。 控制器控制驱动马达以与激光能量的发射同步地自动移动光纤，并自动校准纤维远端相对于导管远端的位置。 纤维在其尖端处具有扩大部分，其前表面涂覆有非金属的并且对脉冲部分透明的吸热材料。 外引导构件为7法兰以上，具有可偏转的远端。 润滑剂位于光纤与引导件的内腔表面之间以及外引导件的外表面上。 位置检测部件由光纤和外引导部件在其远端处或附近承载。

    Method for making a packaging sheath for intra-aortic balloon catheters
    7.
    发明授权
    Method for making a packaging sheath for intra-aortic balloon catheters 失效
    用于制作主动脉内气囊导管的包装护套的方法

    公开(公告)号：US5935501A

    公开(公告)日：1999-08-10

    申请号：US483923

    申请日：1995-06-07

    申请人： Robert R. Andrews ,  William Edelman ,  Ilyssa A. Hunt

    发明人： Robert R. Andrews ,  William Edelman ,  Ilyssa A. Hunt

    IPC分类号： A61B17/00 ,  A61M25/00 ,  B29C33/12 ,  B29C45/14

    CPC分类号： A61M25/002

    摘要： An intra-aortic balloon packaging sheath is provided which includes a long slim extruded plastic tube for storing a furled thin-walled intra-aortic balloon. An entry section of the same plastic is injection molded onto one end of the tube, with the entry section including an outwardly flared entry port surface which is spaced from one end of the tube, and an internal passageway which is co-linear and congruent with the internal cross-section of the tube from the respective end of the tube through the intersection of the second internal passageway with the outwardly flared passageway. Thereby a smooth internal surface is provided through the flared passageway into the internal passageway and through the later into the tube. The exit end of the sheath tube is inverted by use of a heated tipping die such that a distal end portion is turned outwardly and back circumjacent another portion of the tube wall to form a smoothly rounded exit passageway of the tube at the exit end.

    摘要翻译： 提供了一种主动脉内气囊包装护套，其包括用于储存卷曲的薄壁主动脉内球囊的长纤维挤出塑料管。 相同塑料的入口部分注射成型到管的一端，入口部分包括与管的一端间隔开的向外扩张的入口表面，以及内部通道，其与 管的相应端部的管的内部横截面通过第二内部通道与向外扩张的通道的相交。 因此，通过扩口通道提供平滑的内表面进入内部通道并且通过稍后进入管中。 护套管的出口端通过使用加热的接头模具反转，使得远端部分向外转动并且绕管壁的另一部分返回，以在出口端处形成光滑的圆形出口通道。

    Reaction apparatus employing gravitational flow
    8.
    发明授权
    Reaction apparatus employing gravitational flow 失效
    采用重力流的反应装置

    公开(公告)号：US5225163A

    公开(公告)日：1993-07-06

    申请号：US873710

    申请日：1992-04-22

    申请人： Robert R. Andrews

    发明人： Robert R. Andrews

    IPC分类号： B01L3/00 ,  G01N33/53

    CPC分类号： B01L3/502 ,  G01N33/5302

    摘要： A diagnostic device provides the flow of a desired reaction mixture under the force of gravity through a channel. The flow of the reaction mixture gains necessary energy to bring about a physical or a chemical reaction of the reaction mixture. A viewing chamber at the end of the channel retains results of the reaction. The device allows a timed reaction to take place without application of external forces such as vibration, rocking, optical activation, heat or pulsing. Alternative chambers at an entry end of the channel are used to introduce a secondary reaction mixture or reagents. A vent to the channel provides an indication of volume of the reactants and can also function as a viewing area. Channel configurations include various paths of flow and various inner wall geometries.

    摘要翻译： 诊断装置通过通道在重力作用下提供所需反应混合物的流动。 反应混合物的流动获得必要的能量以引起反应混合物的物理或化学反应。 在通道末端的观察室保留反应结果。 该装置允许定时反应发生，而不施加诸如振动，摇摆，光学激活，热或脉冲之类的外力。 在通道的入口端的替代室用于引入第二反应混合物或试剂。 通道的通风口提供了反应物体积的指示，也可以用作观察区域。 通道配置包括各种流动路径和各种内壁几何形状。

    Method of forming intra-aortic balloon catheters
    9.
    发明授权
    Method of forming intra-aortic balloon catheters 失效
    形成主动脉内气囊导管的方法

    公开(公告)号：US5718861A

    公开(公告)日：1998-02-17

    申请号：US484894

    申请日：1995-06-07

    申请人： Robert R. Andrews ,  William Edelman ,  Joseph A. Levendusky ,  Peter T. Majeski ,  Robert L. O'Brien

    发明人： Robert R. Andrews ,  William Edelman ,  Joseph A. Levendusky ,  Peter T. Majeski ,  Robert L. O'Brien

    IPC分类号： A61F2/958 ,  A61M1/10 ,  A61M25/00 ,  B29C41/14 ,  B29C55/22 ,  B29C71/02

    CPC分类号： B29C55/22 ,  A61M1/1072 ,  A61M25/1029 ,  A61M25/1034 ,  B29C41/14 ,  A61M25/0045 ,  A61M25/10 ,  B29L2031/7542

    摘要： A method of forming intra-aortic balloons includes forming a balloon blank having a sleeve section at its proximal end. To reduce the diameter of the sleeve section of the balloon, the sleeve section is stretched longitudinally by gripping a first portion of the balloon blank at the distal end of the sleeve section, gripping a second portion of the balloon blank at the opposite end of the sleeve section and moving at least one of the gripped portions away from the other so as to reduce the diameter of the sleeve section. A heating element is positioned within the sleeve section to relieve the stress in the sleeve after stretching, by heating the sleeve section. The sleeve section is then cooled in order to preserve the sleeve section in its reduced diameter state thereby forming an intra-aortic balloon having a balloon blank with a reduced diameter sleeve section.

    摘要翻译： 形成主动脉内球囊的方法包括在其近端形成具有套筒部分的球囊坯料。 为了减小气囊的套筒部分的直径，通过在套筒部分的远端处抓住球囊坯料的第一部分来纵向地拉伸套管部分，在该套筒部分的相对端处抓住气球坯料的第二部分 套筒部分，并且将夹持部分中的至少一个远离另一个移动，以减小套筒部分的直径。 加热元件定位在套筒部分内，以通过加热套筒部分来拉伸拉伸后的套筒中的应力。 然后将套筒部分冷却以便将套管部分保持在其缩径状态，从而形成具有直径减小的套管部分的球囊坯料的主动脉内球囊。

    Packaging sheaths for intra-aortic balloon catheters
    10.
    发明授权
    Packaging sheaths for intra-aortic balloon catheters 失效
    用于主动脉内气囊导管的包装护套

    公开(公告)号：US5524757A

    公开(公告)日：1996-06-11

    申请号：US210551

    申请日：1994-03-18

    申请人： Robert R. Andrews ,  William Edelman ,  Ilyssa A. Hunt

    发明人： Robert R. Andrews ,  William Edelman ,  Ilyssa A. Hunt

    IPC分类号： A61B17/00 ,  A61M25/00 ,  B65D81/18

    CPC分类号： A61M25/002

    摘要： An intra-aortic balloon packaging sheath is provided which includes a long slim extruded plastic tube for storing a furled thin-walled intra-aortic balloon. An entry section of the same plastic is injection molded onto one end of the tube, with the entry section including an outwardly flared entry port surface which is spaced from one end of the tube, and an internal passageway which is co-linear and congruent with the internal cross-section of the tube from the respective end of the tube through the intersection of the second internal passageway with the outwardly flared passageway. Thereby a smooth internal surface is provided through the flared passageway into the internal passageway and through the later into the tube. The exit end of the sheath tube is inverted by use of a heated tipping die such that a distal end portion is turned outwardly and back circumjacent another portion of the tube wall to form a smoothly rounded exit passageway of the tube at the exit end.

    摘要翻译： 提供了一种主动脉内气囊包装护套，其包括用于储存卷曲的薄壁主动脉内球囊的长纤维挤出塑料管。 相同塑料的入口部分注射成型到管的一端，入口部分包括与管的一端间隔开的向外扩张的入口表面，以及内部通道，其与 管的相应端部的管的内部横截面通过第二内部通道与向外扩张的通道的相交。 因此，通过扩口通道提供平滑的内表面进入内部通道并且通过稍后进入管中。 护套管的出口端通过使用加热的接头模具反转，使得远端部分向外转动并且绕管壁的另一部分返回，以在出口端处形成光滑的圆形出口通道。