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1.发明授权公开(公告)号：US06902562B1
公开(公告)日：2005-06-07
申请号：US09493423
申请日：2000-01-29
申请人： Charles Christopher Negus , Stephen J. Linhares , Robert I. Rudko , Eileen A. Woodruff , Robert R. Andrews
发明人： Charles Christopher Negus , Stephen J. Linhares , Robert I. Rudko , Eileen A. Woodruff , Robert R. Andrews
CPC分类号： A61B18/24 , A61B90/39 , A61B2017/00247 , A61B2018/00392 , A61B2090/3933
摘要： A system and method of marking percutaneous myocardial revascularization channels in a human heart and introducing into the channels a therapeutic or diagnostic agent by inserting a catheter system into the left ventricle of a heart, applying tissue ablative energy through the catheter to create a channel into the heart wall, introducing an imaging medium to the heart wall proximate the channel for marking the position of that channel for imaging, and introducing in or proximate the channel a therapeutic or diagnostic agent.
摘要翻译： 一种在人类心脏中标记经皮心肌血运重建通道的系统和方法，通过将导管系统插入心脏的左心室，将通过导管的组织消融能量施加到通道中，从而向通道中引入治疗或诊断剂，以形成通道 心脏壁，将成像介质引入靠近通道的心脏壁，用于标记用于成像的通道的位置，以及在通道中或其附近引入治疗剂或诊断剂。
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公开(公告)号：US06241665B1
公开(公告)日：2001-06-05
申请号：US09176506
申请日：1998-10-21
申请人： Charles Christopher Negus , Robert R. Andrews , Stephen J. Linhares , Robert I. Rudko , Eileen A. Woodruff
发明人： Charles Christopher Negus , Robert R. Andrews , Stephen J. Linhares , Robert I. Rudko , Eileen A. Woodruff
IPC分类号： A61B500
CPC分类号： A61B5/6857 , A61B5/0422 , A61B6/12 , A61B2562/0209 , A61B2562/043
摘要： A percutaneous mapping system includes a mapping wire, for percutaneous insertion into an internal body cavity, having a plurality of spaced imaging markers; and an insertion device for deploying the mapping wire in a spiral configuration inside the cavity with the markers distributed about the inner wall of the cavity.
摘要翻译： 经皮贴图系统包括：映射线，用于经皮插入到内部体腔中，具有多个间隔开的成像标记; 以及插入装置，用于将所述映射线部分以所述腔内的螺旋构造展开，并且所述标记分布在所述腔的内壁周围。
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公开(公告)号：US5897550A
公开(公告)日：1999-04-27
申请号：US761987
申请日：1996-12-11
CPC分类号： A61B18/201 , A61B2017/00026 , A61B2017/00039 , A61B2017/00106 , A61B2017/00247 , A61B2018/00392 , A61B2218/005
摘要： A sensor system for detecting concealed blood vessels including a handpiece having a passage for transmitting a laser beam and a detector housing at the distal end of the handpiece, the housing including a common electrode, a plurality of segmented electrodes spaced from the common electrode and between the common electrode and the segmented electrodes a plurality of four sensitive elements having an electrical characteristic which varies with the force applied; and an indicator device responsive to variations in the electrical characteristic for representing the presence of a concealed vessel.
摘要翻译： 一种用于检测隐藏血管的传感器系统，其包括具有用于在所述手持件的远端处传送激光束的通道和检测器壳体的手持件，所述壳体包括公共电极，与所述公共电极间隔开的多个分段电极以及 公共电极和分段电极具有随着施加的力而变化的电特性的多个四个敏感元件; 以及响应于电特性的变化以表示隐藏的容器的存在的指示器装置。
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公开(公告)号：US6030377A
公开(公告)日：2000-02-29
申请号：US731862
申请日：1996-10-21
CPC分类号： A61B18/24 , A61B2017/00247 , A61B2018/00392 , A61B2090/3933 , A61B90/39
摘要： A system and method of marking percutaneous transmyocardial revascularization channels in a human heart includes inserting a catheter system into the left ventricle of a heart, applying tissue ablative energy through the catheter to create a channel into the heart wall, and introducing an imaging medium to the heart wall proximate the channel for marking the position of that channel for imaging.
摘要翻译： 在人心脏中标记经皮心肌血运重建通道的系统和方法包括将导管系统插入心脏的左心室，通过导管施加组织消融能量以产生通向心壁的通道，并将成像介质引入到 靠近通道的心壁，用于标记该通道的位置用于成像。
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公开(公告)号：US5724975A
公开(公告)日：1998-03-10
申请号：US764052
申请日：1996-12-12
CPC分类号： A61B8/02 , A61B8/12 , A61B2017/00247 , A61B2018/00392 , A61B8/4405
摘要： An ultrasonic detection system for transmyocardial revascularization (TMR) is disclosed using a detector in the TMR handpiece for detecting concealed coronary blood vessels as well as verifying completion of transmural TMR channels by displaying the detector's output on a video monitor or analyzing the detector output electronically to identify those conditions.
摘要翻译： 公开了一种用于经心肌血运重建的超声波检测系统（TMR），该检测器用于检测隐藏的冠状血管的TMR手持器中的检测器，以及通过在视频监视器上显示检测器的输出或者以电子方式分析检测器的输出来验证透壁TMR通道的完成 识别这些条件。
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6.发明授权Gauging system for monitoring channel depth in percutaneous endocardial revascularization 失效用于监测经皮心内膜血运重建的通道深度的测量系统
公开(公告)号：US5893848A
公开(公告)日：1999-04-13
申请号：US735658
申请日：1996-10-24
IPC分类号： A61B18/20 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61B18/24 , A61B19/00 , A61B5/05
CPC分类号： A61B18/00 , A61B18/1492 , A61B18/24 , A61B2017/00022 , A61B2017/00106 , A61B2017/00247 , A61B2018/00392 , A61B2018/00738 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/033 , A61B2090/062 , A61B34/20
摘要： A gauging system for monitoring channel depth in percutaneous endocardial revascularization surgery includes a catheter for percutaneous insertion into a heart chamber, including a source of tissue ablative energy for ablating a part of the wall of the heart chamber where a channel is to be created; a sensor device proximate the distal end of the catheter for sensing a boundary of the heart wall proximate the channel; and a detection circuit, responsive to the sensor device, for determining the position of the terminus of the channel in the heart chamber; alternatively, a mechanical stop extending radially beyond the distal tip may be used for physically limiting penetration of the catheter tip into the drilled channels.
摘要翻译： 用于监测经皮心内血运重建手术中的通道深度的测量系统包括用于经皮插入心脏腔室的导管，包括用于烧蚀要在其中产生通道的心室的壁的一部分的组织消融能量源; 靠近导管远端的传感器装置，用于感测靠近通道的心脏壁的边界; 以及响应于所述传感器装置的检测电路，用于确定所述心室中所述通道的末端的位置; 或者，径向延伸超过远端的机械止动件可用于物理地限制导管尖端穿入钻孔中。
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公开(公告)号：US5830210A
公开(公告)日：1998-11-03
申请号：US734135
申请日：1996-10-21
CPC分类号： A61N1/056 , A61B18/1492 , A61B18/1815 , A61B18/24 , A61B2017/00247 , A61B2018/00392 , A61B2018/2238
摘要： A catheter navigation apparatus includes a catheter system for percutaneous insertion into an internal organ cavity. The catheter system includes a treatment catheter and a navigation catheter; the navigation catheter includes a deployable framework at its distal end; the treatment catheter includes at least one conduit extending from its proximal to its distal end; the conduit having its distal end engaged with the framework; the navigation catheter includes a flexible link interconnecting the framework with a control mechanism at the proximal end of the navigation catheter for driving the link to deploy and retract the framework to guide the distal tip of the treatment catheter to target one or more selected positions on the inner wall of the organ cavity.
摘要翻译： 导管导航装置包括用于经皮插入内部器官腔的导管系统。 导管系统包括治疗导管和导航导管; 导航导管在其远端包括可展开的框架; 治疗导管包括从其近端延伸到其远端的至少一个导管; 导管的远端与框架接合; 导航导管包括将框架与导航导管的近端处的控制机构相互连接的柔性连杆，用于驱动连杆以展开和缩回框架，以引导治疗导管的远侧末端以对准位于 器官腔内壁。
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8.发明授权公开(公告)号：US06461351B1
公开(公告)日：2002-10-08
申请号：US09687924
申请日：2000-10-13
申请人： Eileen A. Woodruff , Robert R. Andrews , Richard Yeomans , Stephen J. Linhares , Robert I. Rudko
发明人： Eileen A. Woodruff , Robert R. Andrews , Richard Yeomans , Stephen J. Linhares , Robert I. Rudko
IPC分类号： A61B1804
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1492 , A61B18/1815 , A61B18/24 , A61B2017/00084 , A61B2017/00106 , A61B2017/00247 , A61B2018/00011 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00363 , A61B2018/00392 , A61B2018/00702 , A61B2018/00726 , A61B2018/00738 , A61B2018/00744 , A61B2018/00791 , A61B2018/00839 , A61B2018/0091 , A61B2018/1435 , A61B2018/1475 , A61B2090/062
摘要： An energy delivery system for performing myocardial revascularization on a heart of a patient including an energy pulse source that produces energy pulses sufficient to create channels in a wall of a heart, and an energy pulse delivery system connected to receive the energy pulses and deliver the energy pulses to desired locations for channels in the wall of the heart. Also disclosed are a sensor that senses a cyclical event related to the contraction and expansion of the beating heart; a controller responsive to the sensor for automatically firing the energy pulse system to provide energy to strike the beating heart only within a safe time period during a heart beat cycle; RF electrical or laser energy pulses; a temperature sensor to avoid damage caused by overheating adjacent heart tissue; a thermal conductivity cooling system; and programmably adjusting duty cycle, duration and amplitude of energy pulses.
摘要翻译： 一种用于在患者心脏上进行心肌血运重建的能量输送系统，包括产生足以在心脏壁产生通道的能量脉冲源的能量脉冲源，以及连接以接收能量脉冲并递送能量的能量脉冲输送系统 脉冲到心脏壁中通道的所需位置。 还公开了感测与跳动心脏的收缩和扩张相关的周期性事件的传感器; 控制器，响应于所述传感器，用于自动发射所述能量脉冲系统，以提供能量，以仅在心跳周期内的安全时间段内击打所述跳动心脏; RF电或激光能量脉冲; 一个温度传感器，以避免相邻心脏组织过热造成的损伤; 热导率冷却系统; 并可编程调节能量脉冲的占空比，持续时间和幅度。
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9.发明授权公开(公告)号：US06287297B1
公开(公告)日：2001-09-11
申请号：US09263977
申请日：1999-03-05
申请人： Eileen A. Woodruff , Robert R. Andrews , Richard Yeomans , Stephen J. Linhares , Robert I. Rudko
发明人： Eileen A. Woodruff , Robert R. Andrews , Richard Yeomans , Stephen J. Linhares , Robert I. Rudko
IPC分类号： A61B1818
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1492 , A61B18/1815 , A61B18/24 , A61B2017/00084 , A61B2017/00106 , A61B2017/00247 , A61B2018/00011 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00363 , A61B2018/00392 , A61B2018/00702 , A61B2018/00726 , A61B2018/00738 , A61B2018/00744 , A61B2018/00791 , A61B2018/00839 , A61B2018/0091 , A61B2018/1435 , A61B2018/1475 , A61B2090/062
摘要： An energy delivery system for performing myocardial revascularization on a heart of a patient including an energy pulse source that produces energy pulses sufficient to create channels in a wall of a heart, and an energy pulse delivery system connected to receive the energy pulses and deliver the energy pulses to desired locations for channels in the wall of the heart. Also disclosed are a sensor that senses a cyclical event related to the contraction and expansion of the beating heart; a controller responsive to the sensor for automatically firing the energy pulse system to provide energy to strike the beating heart only within a safe time period during a heart beat cycle; RF electrical or laser energy pulses; a temperature sensor to avoid damage caused by overheating adjacent heart tissue; a thermal conductivity cooling system; and programmably adjusting duty cycle, duration and amplitude of energy pulses.
摘要翻译： 一种用于在患者心脏上进行心肌血运重建的能量输送系统，包括产生足以在心脏壁产生通道的能量脉冲源的能量脉冲源，以及连接以接收能量脉冲并递送能量的能量脉冲输送系统 脉冲到心脏壁中通道的所需位置。 还公开了感测与跳动心脏的收缩和扩张相关的周期性事件的传感器; 控制器，响应于所述传感器，用于自动发射所述能量脉冲系统，以提供能量，以仅在心跳周期内的安全时间段内击打所述跳动心脏; RF电或激光能量脉冲; 一个温度传感器，以避免相邻心脏组织过热造成的损伤; 热导率冷却系统; 并可编程调节能量脉冲的占空比，持续时间和幅度。
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