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8 条记录 (耗时 0.017 秒)

    Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives
    2.
    发明授权
    Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives 失效
    通过给予四氢-β-咔啉衍生物抑制食欲的方法

    公开(公告)号：US4978669A

    公开(公告)日：1990-12-18

    申请号：US363504

    申请日：1989-06-08

    申请人： Jack D. Barchas ,  Glen R. Elliott ,  Peter I. Adriaenssens ,  Robert S. Bitner ,  Stephen S. Bowersox ,  Laszlo Nadasdi

    发明人： Jack D. Barchas ,  Glen R. Elliott ,  Peter I. Adriaenssens ,  Robert S. Bitner ,  Stephen S. Bowersox ,  Laszlo Nadasdi

    IPC分类号： A61K31/435 ,  A61K31/44 ,  A61P3/04 ,  C07D471/04

    CPC分类号： A61K31/44 ,  Y10S514/909

    摘要： Compounds of formula I are useful for suppressing appetite, for altering macronutrient preferences, for suppressing obsessive-compulsive behavior, and for inhibiting cravings and substance abuse: ##STR1## wherein R.sub.1 and R.sub.3 are each independently H, hydroxy-alkyl, alpha-cyanoalkyl, SO.sub.3 H, SO.sub.2 NH.sub.2, or C(O)R, where R is OH, NH.sub.2, lower alkoxy, benzyloxy, or aliphatic amino acyl;R.sub.2 and R.sub.9 are each independently H, lower alkyl, benzyl, succinyl, or C(O)R.sub.4, where R.sub.4 is H, lower alkyl, hydrocarboxy-lower alkylene, or lower alkoxycarboxy-lower alkylene; andR.sub.5, R.sub.6, R.sub.7, and R.sub.8 are each independently H, halo, lower alkyl, hydroxy, lower alkoxy, or two adjacent radicals form methylenedioxy or ethylenedioxy;with the proviso that R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, and R.sub.9 are not simultaneously H.

    摘要翻译： 式I的化合物可用于抑制食欲，改变大量营养素偏好，抑制强迫症行为和抑制欲望和物质滥用：其中R1和R3各自独立地为H，羟基 - 烷基，α 氰基烷基，SO 3 H，SO 2 NH 2或C（O）R，其中R是OH，NH 2，低级烷氧基，苄氧基或脂族氨基酰基; R 2和R 9各自独立地为H，低级烷基，苄基，琥珀酰基或C（O）R 4，其中R 4为H，低级烷基，烃基 - 低级亚烷基或低级烷氧基羧基 - 低级亚烷基; 并且R 5，R 6，R 7和R 8各自独立地为H，卤素，低级烷基，羟基，低级烷氧基或两个相邻基团形成亚甲二氧基或亚乙二氧基; 条件是R1，R2，R3，R5，R6，R7，R8和R9不同时为H.

    Benzothiophenes as appetite suppressants
    8.
    发明授权
    Benzothiophenes as appetite suppressants 失效
    苯并噻吩作为食欲抑制剂

    公开(公告)号：US4971974A

    公开(公告)日：1990-11-20

    申请号：US207652

    申请日：1988-06-16

    申请人： Talmage Bosin ,  Robert S. Bitner ,  Theresa M. Gadbois ,  Victor C. Yu ,  Stephen S. Bowersox

    发明人： Talmage Bosin ,  Robert S. Bitner ,  Theresa M. Gadbois ,  Victor C. Yu ,  Stephen S. Bowersox

    IPC分类号： A61K31/44

    CPC分类号： A61K31/44

    摘要： Compositions comprising a compound of formula 1, and optionally a mild stimulant, are effective anorectics, where formula 1 is: ##STR1## and its pharmaceutically acceptable acid-addition salts, wherein X and Y are each independently hydrogen, hydroxy, methyl, ethyl, propyl, methoxy, ethoxy, propoxy, fluoro, chloro, or bromo.These compounds are effective for reducing appetite globally, or at lower dosage, for altering macronutrient preferences and decreasing substance dependence.

    摘要翻译： 包含式1化合物和任选的温和兴奋剂的组合物是有效的止渴剂，其中式1为：其中X和Y各自独立地为氢，羟基，甲基，乙基， 丙基，甲氧基，乙氧基，丙氧基，氟，氯或溴。 这些化合物对于改善大量营养素偏好和降低物质依赖性在全球或低剂量下有效减少食欲。