公开(公告)号：US4621098A

公开(公告)日：1986-11-04

申请号：US626690

申请日：1984-07-02

申请人： Robert Umminger ,  Walter-Gunar Friebe ,  Wolfgang Kampe ,  Androniki Roesch ,  Otto-Henning Wilhelms

发明人： Robert Umminger ,  Walter-Gunar Friebe ,  Wolfgang Kampe ,  Androniki Roesch ,  Otto-Henning Wilhelms

IPC分类号： C07D295/12 ,  A61K31/04 ,  A61K31/10 ,  A61K31/12 ,  A61K31/135 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/22 ,  A61K31/535 ,  A61K31/5375 ,  A61P37/08 ,  C07C67/00 ,  C07C313/00 ,  C07C315/02 ,  C07C317/00 ,  C07C317/04 ,  C07C317/18 ,  C07C319/14 ,  C07C321/28 ,  C07C323/07 ,  C07C323/12 ,  C07C323/14 ,  C07C323/20 ,  C07C323/22 ,  C07C323/25 ,  C07C323/36 ,  C07C323/52 ,  C07C323/58 ,  C07C323/62 ,  C07C323/65 ,  C07D295/18 ,  C07D295/185 ,  C07C147/107

CPC分类号： C07D295/185 ,  C07C317/00 ,  C07C321/00 ,  C07C323/00 ,  C07C323/25

摘要： The present invention provides thioethers of the general formula: ##STR1## wherein Ar is a phenyl radical which is optionally substituted one, two or three times by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, Q is an oxygen or sulphur atom or an NH group, A is a straight-chained or branched C.sub.2 -C.sub.8 alkylene radical which is optionally substituted by a hydroxyl group or can be interrupted by an ethenylene or ethynylene group, n is 0, 1 or 2, and R is a hydrogen atom or a straight-chained or branched alkyl radical which is optionally substituted one or more times by the same or different radicals selected from alkoxycarbonyl, alkoxy, hydroxyl, carboxyl or optionally substituted carbamoyl or amino; as well as the pharmacologically acceptable salts thereof, with the proviso that A cannot be ethylene when Ar is a phenyl radical, Q is an oxygen atom and R is the group --CH.sub.2 COOH.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.

摘要翻译： 本发明提供以下通式的硫醚：其中Ar是任选被烷基，烯基，烷氧基，烷硫基，烷酰基，羟基，羟基烷基，羧基，烷氧基羰基任选取代一至两次的苯基 ，氨基甲酰基，硝基，氨基或卤素，Q是氧或硫原子或NH基团，A是任选被羟基取代的直链或支链C 2 -C 8亚烷基，或可被亚乙烯或 亚乙炔基，n为0,1或2，R为氢原子或直链或支链烷基，其任选被相同或不同的选自烷氧基羰基，烷氧基，羟基，羧基或基团的基团取代一次或多次 任选取代的氨基甲酰基或氨基; 以及其药理学上可接受的盐，条件是当Ar为苯基时A不能为乙烯，Q为氧原子，R为基团-CH 2 COOH。 本发明还提供了制备这些化合物的方法和含有它们的药物组合物。