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公开(公告)号：US09261447B2
公开(公告)日：2016-02-16
申请号：US13582864
申请日：2011-03-07
CPC分类号： G01N15/0211 , G01N21/53 , G01N2015/0046 , G01N2015/0693 , G01N2021/4704
摘要： A method of monitoring particles in a stack comprises generating on a first side of the stack a beam of light directed towards a second, opposite, side of the stack. The beam is reflected back towards the first side of the stack and through the particles in the stack. An image is obtained of light scattered from the particles. The image is obtained using an imager positioned and oriented to have a field of view that includes unwanted scattered light. The method includes the step of blocking the unwanted scattered light from the image.
摘要翻译： 监测堆叠中的颗粒的方法包括在堆叠的第一侧上产生指向堆叠的第二相对侧的光束。 光束被反射回堆叠的第一侧并穿过堆叠中的颗粒。 获得从颗粒散射的光的图像。 使用定位成定向成具有包括不想要的散射光的视野的成像器来获得图像。 该方法包括从图像中阻挡不想要的散射光的步骤。
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公开(公告)号：US20090021697A1
公开(公告)日：2009-01-22
申请号：US12032650
申请日：2008-02-16
申请人： Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
发明人： Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
CPC分类号： A61B3/125 , A61B5/14532 , A61B5/1455 , G01N21/75 , G01N21/77 , G01N21/78 , G01N2021/758 , G01N2021/7723 , G01N2021/7773 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/18 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2210/63 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要： An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
摘要翻译： 一种眼科装置，其包括全息元件，其包括含有苯基硼酸基团的介质，并且在其中设置全息图，其中该元件的光学特性由于介质的物理性质的变化而改变，并且其中变化 由于介质和眼液中存在的分析物之间的相互作用而产生。
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公开(公告)号：US07998412B2
公开(公告)日：2011-08-16
申请号：US12032650
申请日：2008-02-16
申请人： Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
发明人： Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
IPC分类号： G01N21/00
CPC分类号： A61B3/125 , A61B5/14532 , A61B5/1455 , G01N21/75 , G01N21/77 , G01N21/78 , G01N2021/758 , G01N2021/7723 , G01N2021/7773 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/18 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2210/63 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要： An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
摘要翻译： 一种眼科装置，其包括全息元件，其包括含有苯基硼酸基团的介质，并且在其中设置全息图，其中该元件的光学特性由于介质的物理性质的变化而改变，并且其中变化 由于介质和眼液中存在的分析物之间的相互作用而产生。
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公开(公告)号：US06689316B1
公开(公告)日：2004-02-10
申请号：US09701476
申请日：2001-02-09
IPC分类号： G01N3122
CPC分类号： G01N21/77 , G03H1/02 , G03H1/181 , G03H2001/0044 , G03H2001/186 , G03H2260/16 , Y10T436/10 , Y10T436/11
摘要： A method for the production of a holographic sensor wherein the holographic recording material forming the sensitive element is a polymer matrix, which comprises diffusing into the matrix one or more soluble salts that undergo reaction in situ to form an insoluble sensitive precipitate; and recording a holographic image. This method allows the production of a holographic sensor wherein the holographic recording material forming the sensitive element is an insoluble polymer film.
摘要翻译： 一种用于制造全息传感器的方法，其中形成敏感元件的全息记录材料是聚合物基体，其包括向基质中扩散一种或多种在原位进行反应以形成不溶性敏感沉淀物的可溶性盐; 并记录全息图像。 该方法允许制造全息传感器，其中形成敏感元件的全息记录材料是不溶性聚合物膜。
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公开(公告)号：US08097465B2
公开(公告)日：2012-01-17
申请号：US12133214
申请日：2008-06-04
IPC分类号： G01N21/00
CPC分类号： G03H1/18 , G01N21/75 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要： A holographic sensor comprising a thin film polymer matrix that undergoes a change in response to a substance to be sensed, the matrix containing within its volume a set of two or more holographic recordings, each recording providing a holographic image when the sensor is illuminated, wherein the presence or appearance of each image is visible to the eye as a function of the response of the sensor to the substance to be sensed. The images provide the dynamic range of the sensor. Such a sensor can be used to provide a visible image that changes or appears to the eye in response to an analyte.
摘要翻译： 一种全息传感器，包括经受对待检测物质的响应变化的薄膜聚合物基质，所述基体在其体积内包含一组两个或更多个全息记录，每个记录在传感器被照亮时提供全息图像，其中 每个图像的存在或外观是眼睛可见的，作为传感器对待感测物质的响应的函数。 图像提供传感器的动态范围。 这样的传感器可用于提供响应于分析物而改变或显现于眼睛的可见图像。
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公开(公告)号：US20110286064A1
公开(公告)日：2011-11-24
申请号：US13192992
申请日：2011-07-28
申请人： BARRY BURLES , ROGER BRADLEY MILLINGTON , CHRISTOPHER ROBIN LOWE , SATYAMOORTHY KABILAN , JEFFREY BLYTH
发明人： BARRY BURLES , ROGER BRADLEY MILLINGTON , CHRISTOPHER ROBIN LOWE , SATYAMOORTHY KABILAN , JEFFREY BLYTH
IPC分类号： G02B5/32
CPC分类号： A61B3/125 , A61B5/14532 , A61B5/1455 , G01N21/75 , G01N21/77 , G01N21/78 , G01N2021/758 , G01N2021/7723 , G01N2021/7773 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/18 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2210/63 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要： An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
摘要翻译： 一种眼科装置，其包括全息元件，其包括含有苯基硼酸基团的介质，并且在其中设置全息图，其中该元件的光学特性由于介质的物理性质的变化而改变，并且其中变化 由于介质和眼液中存在的分析物之间的相互作用而产生。
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公开(公告)号：US5989923A
公开(公告)日：1999-11-23
申请号：US718311
申请日：1996-10-28
IPC分类号： G01N21/47 , G01N21/75 , G01N33/543 , G02B5/32 , G03H1/02 , G03H1/18 , G01N33/552
CPC分类号： G03H1/18 , G01N21/4788 , G01N21/75 , G01N33/54373 , G02B5/32 , G03H1/0005 , G03H1/0248 , G03H2001/0033 , G03H2001/0044 , G03H2001/186 , G03H2222/47 , Y10S435/808 , Y10S436/805
摘要： The invention relates to a sensor (9) comprising a hologram (17) supported on or within a holographic support medium (10).A species to be detected is reactive with a substance disposed throughout, the sensor (9). Optionally, a chemical reactive with a species to be detected or a specific binding conjugate of a species to be detected is disposed throughout part of or all of the sensor (9).The resulting reaction(s) cause(s) variation(s) in the hologram (17) or holographic support medium (10) which in turn varies one or more optical characteristic(s) of the hologram (17).The variation in the optical characteristic(s) of the hologram (17) and/or the holographic support medium (10), preferably give(s) rise to a wavelength shift in incident radiation. The variation of the optical parameter is related to the species to be detected.The advantages of the sensor are that it is cheap, easy to manufacture and, once calibrated, reliable and robust.
摘要翻译： PCT No.PCT / GB95 / 00668 Sec。 371日期1996年10月28日第 102（e）日期1996年10月28日PCT 1995年3月27日PCT PCT。 第WO95 / 26499号公报 日期1995年10月5日本发明涉及一种包括支撑在全息支撑介质（10）上或其内的全息图（17）的传感器（9）。 要检测的物种与设置在整个传感器（9）中的物质反应。 任选地，传感器（9）的整个部分或全部设置与被检测物质或待检测物种的特异性结合缀合物反应的化学物质。 所产生的反应导致全息图（17）或全息支撑介质（10）中的变化，其反过来改变全息图（17）的一个或多个光学特性。 全息图（17）和/或全息支持介质（10）的光学特性的变化优选地在入射辐射中产生波长偏移。 光学参数的变化与要检测的物种有关。 传感器的优点是便宜，易于制造，并且一旦校准，可靠和鲁棒。
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公开(公告)号：US20130044216A1
公开(公告)日：2013-02-21
申请号：US13582864
申请日：2011-03-07
IPC分类号： H04N7/18
CPC分类号： G01N15/0211 , G01N21/53 , G01N2015/0046 , G01N2015/0693 , G01N2021/4704
摘要： A method of monitoring particles in a stack comprises generating on a first side of the stack a beam of light directed towards a second, opposite, side of the stack. The beam is reflected back towards the first side of the stack and through the particles in the stack. An image is obtained of light scattered from the particles. The image is obtained using an imager positioned and oriented to have a field of view that includes unwanted scattered light. The method includes the step of blocking the unwanted scattered light from the image.
摘要翻译： 监测堆叠中的颗粒的方法包括在堆叠的第一侧上产生指向堆叠的第二相对侧的光束。 光束被反射回堆叠的第一侧并穿过堆叠中的颗粒。 获得从颗粒散射的光的图像。 使用定位成定向成具有包括不想要的散射光的视野的成像器来获得图像。 该方法包括从图像中阻挡不想要的散射光的步骤。
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公开(公告)号：US08241574B2
公开(公告)日：2012-08-14
申请号：US13192992
申请日：2011-07-28
申请人： Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
发明人： Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
CPC分类号： A61B3/125 , A61B5/14532 , A61B5/1455 , G01N21/75 , G01N21/77 , G01N21/78 , G01N2021/758 , G01N2021/7723 , G01N2021/7773 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/18 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2210/63 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要： An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
摘要翻译： 一种眼科装置，其包括全息元件，其包括含有苯基硼酸基团的介质，并且在其中设置全息图，其中该元件的光学特性由于介质的物理性质的变化而改变，并且其中变化 由于介质和眼液中存在的分析物之间的相互作用而产生。
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公开(公告)号：US20080241952A1
公开(公告)日：2008-10-02
申请号：US12133214
申请日：2008-06-04
CPC分类号： G03H1/18 , G01N21/75 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要： A holographic sensor comprising a thin film polymer matrix that undergoes a change in response to a substance to be sensed, the matrix containing within its volume a set of two or more holographic recordings, each recording providing a holographic image when the sensor is illuminated, wherein the presence or appearance of each image is visible to the eye as a function of the response of the sensor to the substance to be sensed. The images provide the dynamic range of the sensor. Such a sensor can be used to provide a visible image that changes or appears to the eye in response to an analyte.
摘要翻译： 一种全息传感器，包括经受对待检测物质的响应变化的薄膜聚合物基质，所述基体在其体积内包含一组两个或更多个全息记录，每个记录在传感器被照亮时提供全息图像，其中 每个图像的存在或外观是眼睛可见的，作为传感器对待感测物质的响应的函数。 图像提供传感器的动态范围。 这样的传感器可用于提供响应于分析物而改变或显现于眼睛的可见图像。
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