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公开(公告)号:US07998412B2
公开(公告)日:2011-08-16
申请号:US12032650
申请日:2008-02-16
申请人: Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
发明人: Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
IPC分类号: G01N21/00
CPC分类号: A61B3/125 , A61B5/14532 , A61B5/1455 , G01N21/75 , G01N21/77 , G01N21/78 , G01N2021/758 , G01N2021/7723 , G01N2021/7773 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/18 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2210/63 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要: An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
摘要翻译: 一种眼科装置,其包括全息元件,其包括含有苯基硼酸基团的介质,并且在其中设置全息图,其中该元件的光学特性由于介质的物理性质的变化而改变,并且其中变化 由于介质和眼液中存在的分析物之间的相互作用而产生。
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公开(公告)号:US20090021697A1
公开(公告)日:2009-01-22
申请号:US12032650
申请日:2008-02-16
申请人: Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
发明人: Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
CPC分类号: A61B3/125 , A61B5/14532 , A61B5/1455 , G01N21/75 , G01N21/77 , G01N21/78 , G01N2021/758 , G01N2021/7723 , G01N2021/7773 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/18 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2210/63 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要: An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
摘要翻译: 一种眼科装置,其包括全息元件,其包括含有苯基硼酸基团的介质,并且在其中设置全息图,其中该元件的光学特性由于介质的物理性质的变化而改变,并且其中变化 由于介质和眼液中存在的分析物之间的相互作用而产生。
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公开(公告)号:US08241574B2
公开(公告)日:2012-08-14
申请号:US13192992
申请日:2011-07-28
申请人: Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
发明人: Barry Burles , Roger Bradley Millington , Christopher Robin Lowe , Satyamoorthy Kabilan , Jeffrey Blyth
CPC分类号: A61B3/125 , A61B5/14532 , A61B5/1455 , G01N21/75 , G01N21/77 , G01N21/78 , G01N2021/758 , G01N2021/7723 , G01N2021/7773 , G03H1/0248 , G03H1/0406 , G03H1/0408 , G03H1/18 , G03H1/2249 , G03H1/265 , G03H1/28 , G03H2001/0044 , G03H2001/0415 , G03H2001/0432 , G03H2001/186 , G03H2001/2263 , G03H2001/2284 , G03H2001/2615 , G03H2001/2655 , G03H2001/266 , G03H2210/20 , G03H2210/22 , G03H2210/30 , G03H2210/45 , G03H2210/52 , G03H2210/63 , G03H2250/40 , G03H2270/12 , G03H2270/55
摘要: An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
摘要翻译: 一种眼科装置,其包括全息元件,其包括含有苯基硼酸基团的介质,并且在其中设置全息图,其中该元件的光学特性由于介质的物理性质的变化而改变,并且其中变化 由于介质和眼液中存在的分析物之间的相互作用而产生。
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公开(公告)号:US08241819B2
公开(公告)日:2012-08-14
申请号:US12340104
申请日:2008-12-19
申请人: Christopher Robin Lowe , Colin Alexander Bennett Davidson , Jeffrey Blyth , Satyamoorthy Kabilan , Alexander James Marshall , Blanca Madrigal Gonzalez , Anthony Peter James
发明人: Christopher Robin Lowe , Colin Alexander Bennett Davidson , Jeffrey Blyth , Satyamoorthy Kabilan , Alexander James Marshall , Blanca Madrigal Gonzalez , Anthony Peter James
IPC分类号: G03H1/02
CPC分类号: G01N21/7703 , G01N21/4788 , G02B5/32 , G03H2001/0044 , G03H2250/44 , G03H2270/53
摘要: A sensor for the detection of an analyte, comprising a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the hologram changes as a result of a variation of a physical property occurring throughout the volume of the medium, wherein the medium is obtainable by formation in situ in the presence of a pore-forming agent, wherein the agent is not present in the sensor or does not react with the analyte and the sensor.
摘要翻译: 一种用于检测分析物的传感器,包括全息元件,该全息元件包括介质和设置在介质整个体积中的全息图,其中全息图的光学特性由于在整个体积内发生的物理性质的变化而改变 介质,其中介质可以通过在成孔剂存在下原位形成而获得,其中该试剂不存在于传感器中或不与分析物和传感器反应。
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5.
公开(公告)号:US20090098467A1
公开(公告)日:2009-04-16
申请号:US12340104
申请日:2008-12-19
申请人: Christopher Robin Lowe , Colin Alexander Bennett Davidson , Jeffrey Blyth , Satyamoorthy Kabilan , Alexander James Marshall , Blanca Madrigal Gonzalez , Anthony Peter James
发明人: Christopher Robin Lowe , Colin Alexander Bennett Davidson , Jeffrey Blyth , Satyamoorthy Kabilan , Alexander James Marshall , Blanca Madrigal Gonzalez , Anthony Peter James
IPC分类号: G03F7/027
CPC分类号: G01N21/7703 , G01N21/4788 , G02B5/32 , G03H2001/0044 , G03H2250/44 , G03H2270/53
摘要: A sensor for the detection of an analyte, comprising a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the hologram changes as a result of a variation of a physical property occurring throughout the volume of the medium, wherein the medium is obtainable by formation in situ in the presence of a pore-forming agent, wherein the agent is not present in the sensor or does not react with the analyte and the sensor.
摘要翻译: 一种用于检测分析物的传感器,包括全息元件,该全息元件包括介质和设置在介质整个体积中的全息图,其中全息图的光学特性由于在整个体积内发生的物理性质的变化而改变 介质,其中介质可以通过在成孔剂存在下原位形成而获得,其中该试剂不存在于传感器中或不与分析物和传感器反应。
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公开(公告)号:US07402441B2
公开(公告)日:2008-07-22
申请号:US10509782
申请日:2003-04-04
申请人: Christopher Robin Lowe , Colin Alexander Bennett Davidson , Jeffrey Blyth , Satyamoorthy Kabilan , Alexander James Marshall , Blanca Madrigal Gonzalez , Anthony Peter James
发明人: Christopher Robin Lowe , Colin Alexander Bennett Davidson , Jeffrey Blyth , Satyamoorthy Kabilan , Alexander James Marshall , Blanca Madrigal Gonzalez , Anthony Peter James
IPC分类号: G01N33/543
CPC分类号: G02B5/32 , G01N21/05 , G01N21/4788 , G01N2021/7723 , G03H1/0248 , G03H2001/0044 , Y10S435/808 , Y10S436/805
摘要: A method for the detection of an analyte in a fluid, comprising contacting the fluid with a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, wherein the variation arises as a result of interaction between the medium and the analyte, and wherein the reaction and the variation are reversible; and detecting any change of the optical characteristic.
摘要翻译: 一种用于检测流体中的分析物的方法,包括使所述流体与包括介质的全息元件和设置在所述介质的整个体积中的全息图接触,其中所述元件的光学特性由于a的变化而变化 在介质的整个体积中发生的物理性质,其中由于介质和分析物之间的相互作用而产生变化,并且其中反应和变化是可逆的; 并检测光学特性的任何变化。
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公开(公告)号:US08048680B2
公开(公告)日:2011-11-01
申请号:US10545275
申请日:2004-02-13
申请人: Christopher Robin Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Kate Sartain , Mei-Ching Lee
发明人: Christopher Robin Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Kate Sartain , Mei-Ching Lee
IPC分类号: C12P19/22
CPC分类号: G03H1/02 , G02B5/32 , G03H2260/12 , Y10T436/143333 , Y10T436/144444
摘要: A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (I): wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.
摘要翻译: 一种用于检测包含顺式二醇部分的分析物的传感器,其包括全息元件,该全息元件包括介质和设置在介质的整个体积中的全息图,其中该元件的光学特性由于 介质是包含式(I)的基团的聚合物:其中n为0,1,2,3或4; 每个X(如果存在)独立地是通过电子效应促进形成围绕硼原子的四面体几何形状的原子或基团; 并且Y是间隔基,当n为0或以其它方式任选时,其是通过电子效应促进围绕硼原子形成四面体几何形状的原子或基团。 这种传感器可用于检测葡萄糖。
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公开(公告)号:US20100167416A1
公开(公告)日:2010-07-01
申请号:US12093038
申请日:2006-11-08
申请人: Satyamoorthy Kabilan , Mei-Ching Lee , Adrian Martin Horgan , Kathryn Elizabeth Sorrell Medlock , Christopher Robin Lowe , Jeffrey Blyth
发明人: Satyamoorthy Kabilan , Mei-Ching Lee , Adrian Martin Horgan , Kathryn Elizabeth Sorrell Medlock , Christopher Robin Lowe , Jeffrey Blyth
CPC分类号: G01N21/4788 , G01N21/453 , G01N33/66 , G02B5/32 , Y10T436/144444
摘要: A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose-binding boronate and a cationic species held within the sensor.
摘要翻译: 传感器包括固定在包含葡萄糖结合硼酸盐和阳离子种类的基质中或基质中的相应受体和供体化合物,由此在葡萄糖存在下,受体和供体化合物之间的间距减小。 例如,全息传感器包括葡萄糖结合硼酸盐和保持在传感器内的阳离子物质。
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公开(公告)号:US08334140B2
公开(公告)日:2012-12-18
申请号:US12093038
申请日:2006-11-08
申请人: Satyamoorthy Kabilan , Mei-Ching Lee , Adrian Martin Horgan , Kathryn Elizabeth Sorrell Medlock , Christopher Robin Lowe , Jeffrey Blyth
发明人: Satyamoorthy Kabilan , Mei-Ching Lee , Adrian Martin Horgan , Kathryn Elizabeth Sorrell Medlock , Christopher Robin Lowe , Jeffrey Blyth
IPC分类号: G01N33/00
CPC分类号: G01N21/4788 , G01N21/453 , G01N33/66 , G02B5/32 , Y10T436/144444
摘要: A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose-binding boronate and a cationic species held within the sensor.
摘要翻译: 传感器包括固定在包含葡萄糖结合硼酸盐和阳离子种类的基质中或基质中的相应受体和供体化合物,由此在葡萄糖存在下,受体和供体化合物之间的间距减小。 例如,全息传感器包括葡萄糖结合硼酸盐和保持在传感器内的阳离子物质。
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公开(公告)号:US20120107944A1
公开(公告)日:2012-05-03
申请号:US13284094
申请日:2011-10-28
申请人: Christopher Robin Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Kate Sartain , Mei-Ching Lee
发明人: Christopher Robin Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Kate Sartain , Mei-Ching Lee
IPC分类号: G01N33/66
CPC分类号: G03H1/02 , G02B5/32 , G03H2260/12 , Y10T436/143333 , Y10T436/144444
摘要: A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (i) wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.
摘要翻译: 一种用于检测包含顺式二醇部分的分析物的传感器,其包括全息元件,该全息元件包括介质和设置在介质的整个体积中的全息图,其中该元件的光学特性由于 介质是包含其中n为0,1,2,3或4的式(ⅰ)基团的聚合物; 每个X(如果存在)独立地是通过电子效应促进形成围绕硼原子的四面体几何形状的原子或基团; 并且Y是间隔基,当n为0或以其它方式任选时,其是通过电子效应促进围绕硼原子形成四面体几何形状的原子或基团。 这种传感器可用于检测葡萄糖。
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