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1.发明授权
公开(公告)号：US5356794A
公开(公告)日：1994-10-18
申请号：US941218
申请日：1992-09-04
Applicant: Pierre Fromageot , Roger Genet
Inventor： Pierre Fromageot , Roger Genet
CPC classification number: C12Y104/01019 , C07K1/107 , C07K14/00 , C12N9/0016 , C12P21/02
Abstract: Purified enzymatic preparation derived from Chromobacterium violaceum, having a dehydrogenase activity, method for preparing it and its use in the production of .alpha.,.beta.-dehydrotryptophanyl-peptides.The said method for preparing .alpha.,.beta.-dehydrotryptophanyl-peptides and .alpha.,.beta.-dehydrotryptophanyl-proteins is characterised in that one brings into contact:a peptide or a protein to be converted, anda purified enzymatic preparation having an L-tryptophan dehydrogenase activity and having a specific activity of between 35 and 45 units.seconds.sup.-1 per mole of heme for N-acetyl-L-tryptophanamide (NATA), an apparent molecular weight of the order of 680 kDa, an isoelectric point of the order of 4, a temperature optimum for activity greater than 80.degree. C. and a temperature stability, at a pH of between 3 and 8 and at a temperature of between 20.degree. and 60.degree. C.Use of the dehydropeptides and dehydroproteins obtained as probes, reagents, drugs or cosmetic products.
Abstract translation: 衍生自具有脱氢酶活性的Chromobacterium violaceum的纯化酶制剂及其制备方法及其在α，β-脱羟色氨酰肽的制备中的应用。 所述制备α，β-脱羟色氨酸 - 肽和α，β-脱羟色氨酸 - 蛋白质的方法的特征在于：接触：待转化的肽或蛋白质，以及具有L-色氨酸脱氢酶活性的纯化酶制剂 并且对于N-乙酰基-L-色氨酰胺（NATA），每摩尔血红素具有35至45单位/秒的比活性，表观分子量为680kDa，等电点为4 ，活性最高为80℃以上的温度，温度稳定性，pH为3〜8，温度为20〜60℃。使用得到的脱水肽和脱水蛋白作为探针，试剂， 药品或化妆品。
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2.发明申请CYCLODIPEPTIDE SYNTHASES (CDSS) AND THEIR USE IN THE SYNTHESIS OF LINEAR DIPEPTIDES 审中-公开环磷酰胺合成酶（CDSS）及其在线性代谢合成中的应用公开(公告)号：US20100279334A1
公开(公告)日：2010-11-04
申请号：US12740411
申请日：2007-10-31
Applicant: Ludovic Sauguet , Robert Thai , Pascal Belin , Alain Lecoq , Roger Genet , Jean-Luc Pernodet , Muriel Gondry
Inventor： Ludovic Sauguet , Robert Thai , Pascal Belin , Alain Lecoq , Roger Genet , Jean-Luc Pernodet , Muriel Gondry
CPC classification number: C12N9/104 , C07K1/02 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C12Y203/02
Abstract: Use of CDSs in the synthesis of linear dipeptides, and applications thereof for the in vivo and in vitro synthesis of linear dipeptides, in particular Phe-Leu, Leu-Phe, Phe-Phe, Phe-Tyr, Tyr-Phe, Leu-Leu, Leu-Tyr, Tyr-Leu, Phe-Met, Met-Phe, Leu-Met, Met-Leu, Tyr-Met, Met-Tyr, Met-Met, Tyr-Tyr, Ile-Met, Met-Ile, Leu-Ile, Ile-Leu using the corresponding polynucleotides.
Abstract translation: 线性二肽合成中CDS的应用及其在体内和体外合成线性二肽，特别是Phe-Leu，Leu-Phe，Phe-Phe，Phe-Tyr，Tyr-Phe，Leu-Leu ，Leu-Tyr，Tyr-Leu，Phe-Met，Met-Phe，Leu-Met，Met-Leu，Tyr-Met，Met-Tyr，Met-Met，Tyr-Tyr，Ile-Met，Met-Ile，Leu Ile-Leu，使用相应的多核苷酸。
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3.发明申请CYCLODIPEPTIDE SYNTHETASE AND ITS USE FOR SYNTHESIS OF CYCLO(Tyr-Xaa) CYCLODIPEPTIDES 审中-公开环胞磷酯合成酶及其用于合成CYCLO（Tyr-Xaa）环孢素的用途公开(公告)号：US20110318781A1
公开(公告)日：2011-12-29
申请号：US13165219
申请日：2011-06-21
Applicant: Pascal BELIN , Muriel GONDRY , Robert THAI , Jean-Luc PERNODET , Roger GENET
Inventor： Pascal BELIN , Muriel GONDRY , Robert THAI , Jean-Luc PERNODET , Roger GENET
IPC: C12P21/00
CPC classification number: C12N9/93
Abstract: Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides, in particular cyclo(Tyr-Xaa) cyclodipeptides, wherein Xaa is any amino acid and their derivatives and applications thereof.
Abstract translation: 分离的，天然的或合成的多核苷酸和由所述多核苷酸编码的多肽，其参与环肽的合成，包含所述多核苷酸的重组载体或任何基本上同源的多核苷酸，用所述多核苷酸或所述重组载体修饰的宿主细胞，以及用于体外和 体内合成环肽，特别是环（Tyr-Xaa）环二肽，其中Xaa是任何氨基酸及其衍生物和应用。
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4.发明授权Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives 失效由参与二酮哌嗪衍生物合成的所述多核苷酸编码的多核苷酸和多肽公开(公告)号：US07723082B2
公开(公告)日：2010-05-25
申请号：US11488793
申请日：2006-07-19
Applicant: Muriel Gondry , Roger Genet , Sylvie Lautru , Jean-Luc Pernodet
Inventor： Muriel Gondry , Roger Genet , Sylvie Lautru , Jean-Luc Pernodet
CPC classification number: C07K14/36
Abstract: The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6-substituted by α,β-unsaturated amino acid side chains.
Abstract translation: 本发明涉及新的分离的天然或合成多核苷酸和由所述多核苷酸编码的多肽，涉及二酮哌嗪衍生物的合成，包含所述多核苷酸的载体，用所述多核苷酸转化的微生物，所述多核苷酸和所述多肽的用途，以及用于 二酮哌嗪衍生物的合成，包括由α，β-不饱和氨基酸侧链取代的3-和6-位的环肽和二酮哌嗪衍生物。
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5.发明申请Cyclodipeptide Synthetase and its use for Synthesis of Cyclo(Tyr-Xaa) Cyclodipeptides 审中-公开环肽合成酶及其用于合成环（Tyr-Xaa）环肽的用途公开(公告)号：US20100055737A1
公开(公告)日：2010-03-04
申请号：US12226660
申请日：2006-04-26
Applicant: Pascal Belin , Muriel Gondry , Robert Thai , Jean-Luc Pernodet , Roger Genet
Inventor： Pascal Belin , Muriel Gondry , Robert Thai , Jean-Luc Pernodet , Roger Genet
CPC classification number: C12N9/93
Abstract: Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides, in particular cyclo(Tyr-Xaa) cyclodipeptides, wherein Xaa is any amino acid and their derivatives and applications thereof.
Abstract translation: 分离的，天然的或合成的多核苷酸和由所述多核苷酸编码的多肽，其参与环肽的合成，包含所述多核苷酸的重组载体或任何基本上同源的多核苷酸，用所述多核苷酸或所述重组载体修饰的宿主细胞，以及用于体外和 体内合成环肽，特别是环（Tyr-Xaa）环二肽，其中Xaa是任何氨基酸及其衍生物和应用。
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Patent Agency Ranking
6.发明授权Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives 失效由参与二酮哌嗪衍生物合成的所述多核苷酸编码的多核苷酸和多肽公开(公告)号：US07112425B2
公开(公告)日：2006-09-26
申请号：US10518019
申请日：2003-06-18
Applicant: Muriel Gondry , Roger Genet , Sylvie Lautru , Jean-Luc Pernodet
Inventor： Muriel Gondry , Roger Genet , Sylvie Lautru , Jean-Luc Pernodet
CPC classification number: C07K14/36
Abstract: The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6- substituted by α,β-unsaturated amino acid side chains.
Abstract translation: 本发明涉及新的分离的天然或合成多核苷酸和由所述多核苷酸编码的多肽，涉及二酮哌嗪衍生物的合成，包含所述多核苷酸的载体，用所述多核苷酸转化的微生物，所述多核苷酸和所述多肽的用途，以及用于 二酮哌嗪衍生物的合成，包括由α，β-不饱和氨基酸侧链取代的环肽和3-酮基哌嗪衍生物。
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7.发明授权Device for the assembly or mechanical reinforcement and the anti-corrosion treatment of elements of immersed structures, and assembly and treatment process relating thereto 失效用于组装或机械加强的装置以及浸没结构件的防腐蚀处理，以及与其相关的装配和处理过程
公开(公告)号：US5049005A
公开(公告)日：1991-09-17
申请号：US550229
申请日：1990-07-09
Applicant: Francois Lazare , Roger Genet
Inventor： Francois Lazare , Roger Genet
IPC: E02B17/00
CPC classification number: E02B17/0026 , E02B17/0004 , Y10T403/3926 , Y10T403/7105 , Y10T403/73
Abstract: A device and process for reinforcing underwater structures of branched joints having a main element (1) and at least one secondary element (2), one end to which is integral with the surface of element (1). The device incorporates a flange (3, 3'), a first portion (3') of which is initially fixed to the secondary element (2), and a second portion (3') of which is thereafter fixed to the first portion. The flange portions define an annular space between the flange and the elements. A liquid composition which generates an elastic polymerized material (4) is introduced into an enclosure to fill the annular space and encapsulate the flange, which enclosure defines the outer boundary of the polymerized material (4).
Abstract translation: 一种用于加强具有主要元件（1）和至少一个次要元件（2）的分支接头的水下结构的装置和方法，一个端部与元件（1）的表面成一体。 该装置包括凸缘（3,3'），其第一部分（3'）初始地固定到次要元件（2），并且其后的第二部分（3'）固定到第一部分。 凸缘部分在凸缘和元件之间限定一个环形空间。 产生弹性聚合材料（4）的液体组合物被引入到外壳中以填充环形空间并封装凸缘，该外壳限定聚合材料（4）的外边界。
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公开(公告)号：US20060051837A1
公开(公告)日：2006-03-09
申请号：US10518019
申请日：2003-06-18
Applicant: Muriel Gondry , Roger Genet , Sylvie Lautru , Jean-Luc Pernodet
Inventor： Muriel Gondry , Roger Genet , Sylvie Lautru , Jean-Luc Pernodet
CPC classification number: C07K14/36
Abstract: The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6- substituted by α,β-unsaturated amino acid side chains.
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9.发明申请Cyclodipeptide Synthetases and Their Use for Synthesis of Cyclo(Leu-Leu) Cyclodipeptide 审中-公开环肽肽合成酶及其用于合成环（Leu-Leu）环肽的用途公开(公告)号：US20090264616A1
公开(公告)日：2009-10-22
申请号：US12226661
申请日：2006-04-26
Applicant: Muriel Gondry , Robert Thai , Pascal Belin , Roger Genet , Jean-Luc Pernodet
Inventor： Muriel Gondry , Robert Thai , Pascal Belin , Roger Genet , Jean-Luc Pernodet
Abstract: Isolated, natural or synthetic polynucleotides and the polypeptides encoded by said polynucleotides, that are involved in the synthesis of cyclodipeptides, the recombinant vectors comprising said polynucleotides or any substantially homologous polynucleotides, the host cell modified with said polynucleotides or said recombinant vectors and also methods for in vitro and in vivo synthesizing cyclo(Leu-Leu) cyclodipeptide and its derivatives and applications thereof.
Abstract translation: 分离的，天然的或合成的多核苷酸和由所述多核苷酸编码的多肽，其参与环肽的合成，包含所述多核苷酸或任何基本上同源的多核苷酸的重组载体，用所述多核苷酸或所述重组载体修饰的宿主细胞， 体外和体内合成环（Leu-Leu）环肽及其衍生物及其应用。
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10.发明申请Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives 失效由参与二酮哌嗪衍生物合成的所述多核苷酸编码的多核苷酸和多肽公开(公告)号：US20070048817A1
公开(公告)日：2007-03-01
申请号：US11488793
申请日：2006-07-19
Applicant: Muriel Gondry , Roger Genet , Sylvie Lautru , Jean-Luc Pernodet
Inventor： Muriel Gondry , Roger Genet , Sylvie Lautru , Jean-Luc Pernodet
CPC classification number: C07K14/36
Abstract: The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6-substituted by α,β-unsaturated amino acid side chains.
Abstract translation: 本发明涉及新的分离的天然或合成多核苷酸和由所述多核苷酸编码的多肽，涉及二酮哌嗪衍生物的合成，包含所述多核苷酸的载体，用所述多核苷酸转化的微生物，所述多核苷酸和所述多肽的用途，以及用于 二酮哌嗪衍生物的合成，包括由α，β-不饱和氨基酸侧链取代的3-和6-位的环肽和二酮哌嗪衍生物。
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