公开(公告)号：US4816339A

公开(公告)日：1989-03-28

申请号：US43326

申请日：1987-04-28

申请人： Roger H. Tu ,  Edwin Wang

发明人： Roger H. Tu ,  Edwin Wang

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/06 ,  A61L27/16 ,  A61L27/26 ,  A61L27/50 ,  B29C55/00 ,  A61F1/24

CPC分类号： A61L27/26 ,  A61F2/06 ,  A61L27/16 ,  A61L27/507 ,  B29C55/005 ,  A61F2/0077 ,  A61F2250/0023 ,  B29K2027/18 ,  B29K2105/04 ,  Y10S623/924

摘要： Biologically compatible materials capable of being formed into implants, comprising layers of poly(tetrafluoroethylene) and mixtures of poly(tetrafluoroethylene) and elastomer, having excellent compliance, strength, elasticity and suturability are disclosed. The materials are preferably prepared as implants or vascular grafts by co-extruding a relatively thin luminal layer of poly(tetrafluoroethylene) having a distinct fibral nodal microstructure within a layer of a mixture of poly(tetrafluoroethylene) and elastomer to impart elasticity to the implant. A preferred embodiment comprises a radially asymmetric composite vascular graft having a luminal layer of poly(tetrafluoroethylene), a second layer of poly(tetrafluoroethylene)/elastomer mixture, a third layer of elastomer, and a fourth layer of a monomer fibrous elastomer matrix with each layer having a distinctive pore size, pore shape and porosity to promote tissue ingrowth and periprosthetic tissue anchoring.

公开(公告)号：US5071609A

公开(公告)日：1991-12-10

申请号：US266745

申请日：1988-11-03

申请人： Roger H. Tu ,  Wilfred F. Mathewson ,  Mark A. Roberts

发明人： Roger H. Tu ,  Wilfred F. Mathewson ,  Mark A. Roberts

IPC分类号： B29C55/00 ,  C08J9/00 ,  C08L21/00 ,  C08L27/18

CPC分类号： C08J9/00 ,  B29C55/005 ,  C08L27/18 ,  B29K2027/18 ,  B29K2105/0088 ,  B29K2105/04 ,  C08J2327/18 ,  C08L21/00 ,  Y10T428/31544

摘要： Interpenetrated matrix of polytetrafluoroethylene and elastomer is disclosed. The matrix is formed into a composite material which is flexible, durable, highly porous with a tight microporous structure and improved retractability. The composite material is subjected to a multi-expansion process to produce shaped articles such as films, tubes, rods and filaments with excellent flexibility and elasticity. More particularly, the composite material can be utilized to produce vascular grafts with excellent biological compatibility.

摘要翻译： 公开了聚四氟乙烯和弹性体的互穿基体。 该基质形成复合材料，其具有柔性，耐用，高度多孔性，具有紧密的微孔结构和改进的收缩性。 将复合材料进行多次膨胀处理以产生具有优异的柔性和弹性的成形制品，例如薄膜，管，棒和长丝。 更具体地，复合材料可用于生产具有优异生物相容性的血管移植物。