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公开(公告)号：US09068565B2
公开(公告)日：2015-06-30
申请号：US13463509
申请日：2012-05-03
Applicant: Javier Alarcon , William Riggsbee , Joshua Horvath , Dinesh Kommireddy , Ron J. Pettis
Inventor： Javier Alarcon , William Riggsbee , Joshua Horvath , Dinesh Kommireddy , Ron J. Pettis
IPC: A61K9/14 , F04B43/00 , A61J1/06 , F04B43/08 , B32B27/18 , B32B27/32 , B32B1/08 , A61M5/31 , A61M5/14 , A61J1/14 , A61J1/20 , A61M5/315 , A61M5/24
CPC classification number: F04B43/0072 , A61J1/062 , A61J1/1406 , A61J1/201 , A61M5/14232 , A61M5/3129 , A61M5/31585 , A61M39/08 , A61M2005/2407 , A61M2005/2488 , A61M2205/0238 , B32B1/08 , B32B27/18 , B32B27/32 , B32B2439/80 , F04B43/08 , F05C2225/00 , F05C2231/00
Abstract: A container and method for storing a pharmaceutical agent are provided for enhancing the storage time. The storage time of the pharmaceutical agent is improved by reducing the loss of stabilizing agents in the pharmaceutical agent. The storage container is formed from a polyolefin that includes a stabilizing agent in an amount effective to reduce or inhibit the migration of stabilizing agents in the pharmaceutical agent. The polyolefin container is formed with a fatty acid amide such as erucamide for stabilizing insulin that contains m-cresol and/or phenol as stabilizing agents for the insulin. The fatty acid amide incorporated in the container inhibits and/or reduces the rate of migration of the m-cresol and/or phenol into the polyolefin to extend the storage life of the insulin. The container can be a syringe, such as a pre-filled syringe, a storage vial or the flow path of an infusion pump.
Abstract translation: 提供了用于储存药剂的容器和方法，用于增加储存时间。 通过减少药剂中的稳定剂的损失，改善药剂的储存时间。 储存容器由包含稳定剂的聚烯烃形成，其量可以有效地减少或抑制药剂中稳定剂的迁移。 聚烯烃容器由脂肪酸酰胺如芥酸酰胺形成，用于稳定含有间甲酚和/或苯酚作为胰岛素稳定剂的胰岛素。 引入容器中的脂肪酸酰胺抑制和/或降低间甲酚和/或苯酚进入聚烯烃的速率，以延长胰岛素的储存寿命。 容器可以是注射器，例如预填充的注射器，储存小瓶或输注泵的流动路径。
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公开(公告)号：US20130296235A1
公开(公告)日：2013-11-07
申请号：US13463509
申请日：2012-05-03
Applicant: Javier ALARCON , William RIGGSBEE , Joshua HORVATH , Dinesh KOMMIREDDY , Ron J. PETTIS
Inventor： Javier ALARCON , William RIGGSBEE , Joshua HORVATH , Dinesh KOMMIREDDY , Ron J. PETTIS
CPC classification number: F04B43/0072 , A61J1/062 , A61J1/1406 , A61J1/201 , A61M5/14232 , A61M5/3129 , A61M5/31585 , A61M39/08 , A61M2005/2407 , A61M2005/2488 , A61M2205/0238 , B32B1/08 , B32B27/18 , B32B27/32 , B32B2439/80 , F04B43/08 , F05C2225/00 , F05C2231/00
Abstract: A container and method for storing a pharmaceutical agent are provided for enhancing the storage time. The storage time of the pharmaceutical agent is improved by reducing the loss of stabilizing agents in the pharmaceutical agent. The storage container is formed from a polyolefin that includes a stabilizing agent in an amount effective to reduce or inhibit the migration of stabilizing agents in the pharmaceutical agent. The polyolefin container is formed with a fatty acid amide such as erucamide for stabilizing insulin that contains m-cresol and/or phenol as stabilizing agents for the insulin. The fatty acid amide incorporated in the container inhibits and/or reduces the rate of migration of the m-cresol and/or phenol into the polyolefin to extend the storage life of the insulin. The container can be a syringe, such as a pre-filled syringe, a storage vial or the flow path of an infusion pump.
Abstract translation: 提供了用于储存药剂的容器和方法，用于增加储存时间。 通过减少药剂中的稳定剂的损失，改善药剂的储存时间。 储存容器由包含稳定剂的聚烯烃形成，其量可以有效地减少或抑制药剂中稳定剂的迁移。 聚烯烃容器由脂肪酸酰胺如芥酸酰胺形成，用于稳定含有间甲酚和/或苯酚作为胰岛素稳定剂的胰岛素。 引入容器中的脂肪酸酰胺抑制和/或降低间甲酚和/或苯酚进入聚烯烃的速率，以延长胰岛素的储存寿命。 容器可以是注射器，例如预填充的注射器，储存小瓶或输注泵的流动路径。
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