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公开(公告)号：US06248713B1
公开(公告)日：2001-06-19
申请号：US08498237
申请日：1995-07-11
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
IPC分类号： A61K3803
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1024 , C07K14/78 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S514/903 , Y10S530/868
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
摘要翻译： 本发明涉及可用于抑制和预防细胞粘附和细胞粘附介导的病理学的新型化合物。 本发明还涉及包含这些化合物的药物制剂及其用于抑制和预防细胞粘附和细胞粘附介导的病理学的方法。 本发明的化合物和药物组合物可用作治疗剂或预防剂。 它们特别适用于治疗许多炎性和自身免疫性疾病。
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公开(公告)号：US06875743B1
公开(公告)日：2005-04-05
申请号：US09724139
申请日：2000-11-28
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
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公开(公告)号：US06239108B1
公开(公告)日：2001-05-29
申请号：US08983391
申请日：1998-08-10
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
IPC分类号： A61K3800
CPC分类号： C07K5/0819 , A61K38/00 , C07K5/06043 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0817 , C07K5/0823 , C07K5/101 , C07K5/1013
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
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公开(公告)号：US4705778A
公开(公告)日：1987-11-10
申请号：US790031
申请日：1985-10-22
申请人： Ronald G. Almquist , Cris M. Olsen
发明人： Ronald G. Almquist , Cris M. Olsen
CPC分类号： C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13
摘要： Incorporation of a ketomethylene or a hydroxyethylene group in place of the amide linking group between the Pro.sup.9 and Gly.sup.10 residues of LHRH and its analogs improves the oral activity of LHRH or its analogs.
摘要翻译： 将酮亚甲基或羟基亚乙基代入LHRH及其类似物的Pro9和Gly10残基之间的酰胺连接基团，可改善LHRH或其类似物的口服活性。
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公开(公告)号：US06596687B1
公开(公告)日：2003-07-22
申请号：US09482296
申请日：2000-01-13
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
IPC分类号： A61K3803
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1024 , C07K14/78 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S514/903 , Y10S530/868
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
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公开(公告)号：US5268361A
公开(公告)日：1993-12-07
申请号：US712311
申请日：1991-06-07
IPC分类号： A61K31/16 , A61K31/165 , A61K31/415 , A61K38/00 , A61K38/55 , A61P9/12 , C07C237/22 , C07C317/44 , C07D233/54 , C07D233/64 , C07K5/06 , C07K5/065 , C07K14/81 , A61K37/02
CPC分类号： C07D233/64 , C07K5/06078 , A61K38/00
摘要： Novel compounds useful as renin inhibitors are provided. The compounds are hydroxyazido derivatives having the structural formula ##STR1## wherein the substituents R.sub.1 through R.sub.7 are as defined herein. Analogs of these compounds which are ketozaido derivatives are also provided. Additionally disclosed re methods for using the novel compounds to treat hypertension, and pharmaceutical compositions containing the compounds. Of particular interest are formulations for oral administration.
摘要翻译： 提供了可用作肾素抑制剂的新型化合物。 这些化合物是具有结构式“IMAGE”的羟基叠氮基衍生物，其中取代基R 1至R 7如本文所定义。 也提供了这些化合物的类似物，它们是酮二糖衍生物。 另外公开了使用该新化合物治疗高血压的方法和含有这些化合物的药物组合物。 特别令人感兴趣的是用于口服给药的制剂。
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7.发明授权Isolated atrial peptide-degrading enzyme and novel compounds useful as inhibitors thereof 失效分离的心房肽降解酶和可用作其抑制剂的新化合物
公开(公告)号：US5262521A
公开(公告)日：1993-11-16
申请号：US714540
申请日：1991-06-07
申请人： Ronald G. Almquist , Lawrence Toll
发明人： Ronald G. Almquist , Lawrence Toll
CPC分类号： C12N9/6489 , C07K14/58 , A61K38/00
摘要： A novel atrial peptide-degrading enzyme (ADE) is provided in isolated, purified form. The enzyme has a molecular weight of approximately 160,000 Daltons as measured by gel filtration chromatography, and is effective to cleave atrial peptides such as APII, APIII and ANF. Also provided are novel compounds useful as inhibitors of the enzyme and thus useful as blood pressure lowering agents, pharmaceutical compositions containing the inhibitors, and methods of using the inhibitors.
摘要翻译： 以分离，纯化的形式提供新型心房肽降解酶（ADE）。 该酶通过凝胶过滤色谱法测量的分子量为约160,000道尔顿，并且有效地切割了诸如APII，APIII和ANF的心房肽。 还提供了可用作酶的抑制剂的新化合物，因此可用作降血压剂，含有抑制剂的药物组合物和使用抑制剂的方法。
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8.发明授权Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme 失效氧代烷酸衍生物作为血管紧张素转换酶的抑制剂
公开(公告)号：US4329473A
公开(公告)日：1982-05-11
申请号：US219885
申请日：1980-12-24
IPC分类号： C07D207/16 , C07D263/42 , C07D317/28 , C07D317/30 , C07F7/10 , C07F7/18 , C07D207/12 , C07D401/12 , C07D405/12
CPC分类号： C07F7/10 , C07D207/16 , C07D263/42 , C07D317/28 , C07D317/30 , C07F7/1896
摘要： This invention relates to novel analogs of proline terminal tripeptides and related compounds and is typified by ##STR1## The compounds are potent inhibitors of angiotensin converting enzyme and as such are useful as antihypertensive agents.
摘要翻译： 本发明涉及脯氨酸末端三肽及相关化合物的新类似物，并以5-苯甲酰氨基-4-氧代-6-苯基己酰基-L-脯氨酸为代表。该化合物是血管紧张素转换酶的有效抑制剂，因此可用于 抗高血压药。
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