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    Linear substituted oligoalkyleneimine libraries
    7.
    发明授权
    Linear substituted oligoalkyleneimine libraries 失效
    线性取代的低聚亚烷基亚胺文库

    公开(公告)号：US06197529B1

    公开(公告)日：2001-03-06

    申请号：US08063279

    申请日：1993-05-18

    申请人： Richard A. Houghten ,  Julio Hernan Cuervo ,  Fred F. Weitl

    发明人： Richard A. Houghten ,  Julio Hernan Cuervo ,  Fred F. Weitl

    IPC分类号： G01N33567

    CPC分类号： C07K1/047 ,  B01J19/0046 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00725 ,  C40B40/10

    摘要： Linear substituted oligoalkyleneimine molecules and libraries of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a library contains the same number of 2 to about 10 substituted alkyleneimine repeating units, whose substituents are reduced amino acid side chains bonded to the repeating units at a position alpha to the nitrogen atom, and the member chains of a library are present in equimolar amounts. The chains of a library contain one or more predetermined reduced amino acid side chain-substituted repeating units at one or more predetermined positions of the substituted oligoalkyleneimine chain. The library contains equimolar amounts of at least six different reduced amino acid side chain-substituted repeating units at one or more of the same predetermined positions of the substituted oligoalkyleneimine chain. Particularly preferred linear substituted oligoalkyleneimine molecules and libraries are linear substituted oligoethyleneimines.

    摘要翻译： 公开了线性取代的低聚亚烷基亚胺分子和分子文库，以及其在受体结合测定中的合成和使用方法。 文库的每个分子或链包含相同数量的2至约10个取代的亚烷基亚胺重复单元，其取代基是与氮原子的α位置的键合到重复单元的还原氨基酸侧链，以及文库的成员链 以等摩尔量存在。 文库的链在取代的低聚亚烷基亚胺链的一个或多个预定位置含有一个或多个预定的还原氨基酸侧链取代的重复单元。 该文库在取代的低聚亚烷基亚胺链的一个或多个相同的预定位置包含等摩尔量的至少六个不同的还原氨基酸侧链取代的重复单元。 特别优选的线性取代的低聚亚烷基亚胺分子和文库是线性取代的低聚亚乙基亚胺。