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公开(公告)号：US20140128370A1
公开(公告)日：2014-05-08
申请号：US14151796
申请日：2014-01-09
申请人： Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
发明人： Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要： The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译： 本发明涉及式（I）的取代的四氢 - 吡啶并 - 嘧啶衍生物，其中Y，R 1，R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号：US20100160279A1
公开(公告)日：2010-06-24
申请号：US12442061
申请日：2007-09-04
IPC分类号： A61K31/397 , C07D205/04
CPC分类号： C07D205/04
摘要： The invention relates to compounds of formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）化合物及其制备方法和中间体，它们用作毒蕈碱拮抗剂和含有它们的药物组合物。
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公开(公告)号：US09499536B2
公开(公告)日：2016-11-22
申请号：US14151796
申请日：2014-01-09
申请人： Nigel Graham Cooke , Frédèric Zecri , Nicolas Soldermann , Romain Wolf , Christina Hebach , Klemens Hoegenauer , Gregory John Hollingworth , Anette Von Matt , Ross Sinclair Strang , Alexander Baxter Smith , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Frank Stowasser , Nicola Tufilli
发明人： Nigel Graham Cooke , Frédèric Zecri , Nicolas Soldermann , Romain Wolf , Christina Hebach , Klemens Hoegenauer , Gregory John Hollingworth , Anette Von Matt , Ross Sinclair Strang , Alexander Baxter Smith , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Frank Stowasser , Nicola Tufilli
IPC分类号： A61K31/519 , A61P35/02 , A61P19/02 , C07D471/04
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要： The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译： 本发明涉及式（I）的取代的四氢 - 吡啶并 - 嘧啶衍生物，其中Y，R 1，R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号：US07557121B2
公开(公告)日：2009-07-07
申请号：US11128804
申请日：2005-05-12
IPC分类号： A61K31/44 , C07D515/02
CPC分类号： C07D471/04
摘要： The present invention relates to tetrahydronaphthyridine derivatives of the general formula (I): or of the general formula (I′) in which A and R1 are as defined within, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, including the treatment diseases mediated by H3 ligands, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及通式（I）的四氢萘并吡啶衍生物：或其中A和R 1如上所定义的通式（I'）的化合物，以及制备用于制备组合物的中间体的方法 包括由H3配体介导的治疗疾病，特别是炎性，过敏性和呼吸道疾病，病症和病症的用途。
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公开(公告)号：US20170022199A1
公开(公告)日：2017-01-26
申请号：US15285614
申请日：2016-10-05
申请人： Nigel Graham COOKE , Antonio Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolaus SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
发明人： Nigel Graham COOKE , Antonio Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolaus SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要： The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译： 其中Y，R 1，R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号：US20090258861A1
公开(公告)日：2009-10-15
申请号：US12491370
申请日：2009-06-25
IPC分类号： A61K31/55 , A61K31/506 , A61K31/497 , A61K31/4436 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to tetrahydronaphthyridine derivatives of the general formula (I): or of the general formula (I′) in which A and R1 are as defined within, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, including the treatment diseases mediated by H3 ligands, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及通式（I）的四氢萘并吡啶衍生物：或其中A和R 1如上所定义的通式（I'）的化合物，以及制备用于制备组合物的中间体的方法 包括由H3配体介导的治疗疾病，特别是炎性，过敏性和呼吸道疾病，病症和病症的用途。
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公开(公告)号：US20170267678A1
公开(公告)日：2017-09-21
申请号：US15613560
申请日：2017-06-05
申请人： Nigel Graham COOKE , Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
发明人： Nigel Graham COOKE , Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
IPC分类号： C07D471/04 , A61K31/519 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要： The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
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公开(公告)号：US08263623B2
公开(公告)日：2012-09-11
申请号：US12496054
申请日：2009-07-01
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20100010040A1
公开(公告)日：2010-01-14
申请号：US12496054
申请日：2009-07-01
IPC分类号： A61K31/473 , C07D401/14 , A61P11/06 , A61P11/08 , A61P11/00
CPC分类号： C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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