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公开(公告)号:US20170022199A1
公开(公告)日:2017-01-26
申请号:US15285614
申请日:2016-10-05
申请人: Nigel Graham COOKE , Antonio Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolaus SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
发明人: Nigel Graham COOKE , Antonio Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolaus SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
IPC分类号: C07D471/04 , A61K31/5377 , A61K31/519
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US20140179634A1
公开(公告)日:2014-06-26
申请号:US14194879
申请日:2014-03-03
IPC分类号: C07F9/6558 , C07D401/14
CPC分类号: A61K31/499 , A61K31/675 , A61K45/06 , C07D401/14 , C07F9/65583
摘要: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译: 本发明涉及取代的吲哚衍生物,其制备方法,它们作为药物的用途以及包含它们的药物组合物。
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公开(公告)号:US20130157980A1
公开(公告)日:2013-06-20
申请号:US13471512
申请日:2012-05-15
IPC分类号: A61K31/675 , A61K45/06 , A61K31/499 , C07F9/6558 , C07D401/14
CPC分类号: A61K31/499 , A61K31/675 , A61K45/06 , C07D401/14 , C07F9/65583
摘要: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译: 本发明涉及取代的吲哚衍生物,其制备方法,它们作为药物的用途以及包含它们的药物组合物。
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公开(公告)号:US08431589B2
公开(公告)日:2013-04-30
申请号:US13069816
申请日:2011-03-23
申请人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号: C07D239/48 , A61K31/505
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1 , useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译: 提供式I化合物,其中X,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8和R 9如权利要求1所述,其可用于ZAP-70和/或Syk抑制起作用或 由与FAK连接的信号级联故障引起的。
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公开(公告)号:US20120065183A1
公开(公告)日:2012-03-15
申请号:US13175050
申请日:2011-07-01
申请人: Nigel Graham COOKE , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross STRANG , Nicola TUFILLI , Anette VON MATT , Romain WOLF , Frédéric ZECRI
发明人: Nigel Graham COOKE , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross STRANG , Nicola TUFILLI , Anette VON MATT , Romain WOLF , Frédéric ZECRI
IPC分类号: A61K31/519 , A61K31/5377 , A61P19/02 , A61P17/00 , A61P37/08 , A61P7/06 , A61P25/00 , A61P21/04 , A61P35/00 , C07D471/04 , A61P7/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US20100261766A1
公开(公告)日:2010-10-14
申请号:US12744572
申请日:2008-12-01
IPC分类号: A61K31/4245 , C07D413/10 , C07D305/10 , C07D305/08 , A61P29/00 , A61P37/06 , A61P31/00
CPC分类号: C07D413/10 , C07D305/08 , C07D305/10
摘要: Novel organic compounds are described and claimed which may in particular be useful in the treatment of diseases being triggered by the (human) autoimmune system.
摘要翻译: 描述和要求保护的新型有机化合物,其特别可用于治疗由(人)自身免疫系统触发的疾病。
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公开(公告)号:US20090318546A1
公开(公告)日:2009-12-24
申请号:US12296317
申请日:2007-04-10
申请人: Rolf Baenteli , Nigel Graham Cooke , Sven Weiler , Frederic Zecri
发明人: Rolf Baenteli , Nigel Graham Cooke , Sven Weiler , Frederic Zecri
IPC分类号: A61K31/37 , C07D311/04 , A61P37/02
CPC分类号: C07D311/16
摘要: A compound of formula (I) wherein R1, R2, R3, R4, R5, and ring A are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
摘要翻译: 其中R 1,R 2,R 3,R 4,R 5和环A如说明书中所定义的式(I)化合物处理其制备,其用途,特别是移植,以及含有它们的药物组合物。
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公开(公告)号:US07399771B2
公开(公告)日:2008-07-15
申请号:US10529776
申请日:2003-10-06
申请人: Rainer Albert , Nigel Graham Cooke , Gebhard Thoma , Christian Bruns , François Nuninger , Markus Streiff , Hans-Günter Zerwes
发明人: Rainer Albert , Nigel Graham Cooke , Gebhard Thoma , Christian Bruns , François Nuninger , Markus Streiff , Hans-Günter Zerwes
IPC分类号: A61K31/445 , C07D401/14
CPC分类号: C07D401/14 , C07D211/58 , C07D405/14 , C07D409/14 , C07D417/14
摘要: Disclosed are compounds of formula I: wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.
摘要翻译: 公开了式I化合物:其中R 1,R 2,R 3和X如本文所定义,为游离或盐形式, 其可用作CCR5抑制剂,例如 在预防或治疗由趋化因子受体及其配体之间相互作用介导的疾病。
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公开(公告)号:US20140128370A1
公开(公告)日:2014-05-08
申请号:US14151796
申请日:2014-01-09
申请人: Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
发明人: Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US08703782B2
公开(公告)日:2014-04-22
申请号:US13471512
申请日:2012-05-15
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: A61K31/499 , A61K31/675 , A61K45/06 , C07D401/14 , C07F9/65583
摘要: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译: 本发明涉及取代的吲哚衍生物,其制备方法,它们作为药物的用途以及包含它们的药物组合物。
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