公开(公告)号：US20060165648A1

公开(公告)日：2006-07-27

申请号：US11389864

申请日：2006-03-27

Applicant: Charles Degenhardt ,  Rowan Grayling ,  Christopher Dille ,  Cheryl Tansky

Inventor： Charles Degenhardt ,  Rowan Grayling ,  Christopher Dille ,  Cheryl Tansky

IPC: A01N43/40 ,  A01N43/36 ,  A01N43/00

CPC classification number: C12M41/36 ,  A01N43/36 ,  A01N43/40 ,  A01N43/44 ,  A01N43/46 ,  A01N47/16 ,  C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D223/06

Abstract: The present invention provides nitrogen heterocyclic compounds, compositions, and methods for controlling biofilms, i.e., disrupting biofilms, preventing biofilm formation, enhancing biofilms, or modifying biofilms. Methods for screening test compounds for control of biofilms and devices for use therein are also provided.

公开(公告)号：US20070053849A1

公开(公告)日：2007-03-08

申请号：US11595530

申请日：2006-11-10

Applicant: Matthew Doyle ,  Leo Laughlin ,  Todd Underiner ,  Begonia Ho ,  Rowan Grayling

Inventor： Matthew Doyle ,  Leo Laughlin ,  Todd Underiner ,  Begonia Ho ,  Rowan Grayling

IPC: A61K8/96 ,  A61K8/66

CPC classification number: A61K8/4946 ,  A61K8/02 ,  A61K8/19 ,  A61K8/21 ,  A61K8/22 ,  A61K8/24 ,  A61K8/25 ,  A61K8/27 ,  A61K8/345 ,  A61K8/347 ,  A61K8/37 ,  A61K8/416 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/4973 ,  A61K8/55 ,  A61K8/60 ,  A61K8/673 ,  A61K8/676 ,  A61K8/678 ,  A61K8/731 ,  A61K8/8164 ,  A61K8/86 ,  A61K8/97 ,  A61K8/9706 ,  A61K31/00 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/662 ,  A61K45/06 ,  A61Q11/00 ,  A61Q17/005

Abstract: The present invention encompasses topical oral care compositions comprising the combination of an anti-bacterial agent with an anti-inflammatory agent in an orally acceptable carrier for effective treatment and prevention of bacteria-mediated diseases and conditions in the oral cavity and for modulating host reaction to bacterial pathogens present in the oral cavity and to the toxins, endotoxins, inflammatory cytokines and mediators released by or prompted by these pathogens. The present invention also encompasses methods of use of these compositions comprising topical application to the oral cavity. The benefits of the present compositions and methods extend beyond treating and preventing oral bacterial infections in the oral cavity to promoting whole body or systemic health.

Abstract translation: 本发明包括在口腔可接受的载体中包含抗细菌剂与抗炎剂的组合的局部口腔护理组合物，用于有效治疗和预防细菌介导的口腔疾病和病症并调节宿主对于 存在于口腔中的细菌病原体和由这些病原体释放或促使的毒素，内毒素，炎性细胞因子和介质。 本发明还包括使用这些组合物的方法，其包括局部施用于口腔。 本发明组合物和方法的益处不仅在口腔内治疗和预防口腔细菌感染以促进全身或全身健康。

公开(公告)号：US20060283478A1

公开(公告)日：2006-12-21

申请号：US11507150

申请日：2006-08-21

Applicant: Ruben Avila ,  Daniel Volpenhein ,  Margaret O'Donoghue ,  Matthew Doyle ,  Chanchal Ghosh ,  Rowan Grayling ,  Aleksey Pinyayev

Inventor： Ruben Avila ,  Daniel Volpenhein ,  Margaret O'Donoghue ,  Matthew Doyle ,  Chanchal Ghosh ,  Rowan Grayling ,  Aleksey Pinyayev

IPC: A61C15/00

CPC classification number: A61C15/041 ,  A61C1/088 ,  A61C19/063 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/062 ,  A61N2005/0606 ,  A61N2005/0644

Abstract: Disclosed are various oral care devices and methods. One method includes introducing a composition into the oral cavity, wherein the composition includes a reactive species generating agent. Output from a light emitting element is directed at a portion of the soft tissue of the oral cavity for a period of time sufficient to generate one or more reactive species from the reactive species generating agent.

Abstract translation: 公开了各种口腔护理装置和方法。 一种方法包括将组合物引入口腔，其中组合物包括反应性物质产生剂。 来自发光元件的输出指向口腔软组织的一部分足以从反应物质产生剂产生一种或多种反应性物质的时间。