公开(公告)号：US5679572A

公开(公告)日：1997-10-21

申请号：US239698

申请日：1994-05-09

申请人： Yoshio Okamoto ,  Naoki Enomoto ,  Ryu Ohishi ,  Yasushi Ogasawara ,  Hirofumi Akano ,  Yoshiya Kawamura

发明人： Yoshio Okamoto ,  Naoki Enomoto ,  Ryu Ohishi ,  Yasushi Ogasawara ,  Hirofumi Akano ,  Yoshiya Kawamura

IPC分类号： B01J20/32 ,  C07B57/00 ,  C08B33/00 ,  C08B37/00 ,  B01D15/08 ,  C01B33/12 ,  G01N30/48

CPC分类号： B01J20/3219 ,  B01J20/286 ,  B01J20/289 ,  B01J20/29 ,  B01J20/3274 ,  C07B57/00 ,  C08B33/00 ,  C08B37/00 ,  Y10S435/803

摘要： Provided is a novel polysaccharide derivative having a main structure of the following formula (1) in which a polysaccharide or its derivative has been chemically bonded to the inner and outer surfaces of the pores of a porous carrier at the reducing terminal of the polysaccharide or polysaccharide derivative: ##STR1## Also provided are a method of producing the novel polysaccharide derivative in which a silane agent is chemically bonded to a porous carrier and thereafter a polysaccharide having a degree of polymerization from 11 to 500 or its derivative is further chemically bonded to surface treated carrier at the reducing terminal of the polysaccharide or its derivative, and a method of producing the novel polysaccharide derivative in which a polysaccharide having a degree of polymerization from 11 to 500 or its derivative is chemically bonded to a silane agent at the reducing terminal of the polysaccharide or its derivative and thereafter the polysaccharide derivative is further chemically bonded to a porous carrier. Further provided is a separating agent for chromatography containing the novel polysaccharide derivative. The novel polysaccharide derivative has excellent solvent resistance and is useful as a separating agent for chiral resolution of chiral compounds by chromatography. The methods of the present invention efficiently give the novel polysaccharide derivative.

摘要翻译： 本发明提供一种具有下述通式（1）的主要结构的新型多糖衍生物，其中多糖或其衍生物在多糖或多糖的还原端已经与多孔载体的孔的内表面和外表面化学键合 衍生物：（1）+ TR 还提供了一种制备新型多糖衍生物的方法，其中硅烷试剂与多孔载体化学键合，然后是聚合度为11〜500的多糖或 其衍生物在多糖或其衍生物的还原末端进一步化学键合到表面处理的载体上，以及制备其聚合度为11〜500的多糖或其衍生物与其衍生物化学键合的新型多糖衍生物的方法 多糖或其衍生物的还原末端的硅烷试剂，之后是多糖衍生物 e进一步化学键合到多孔载体上。 还提供了含有新型多糖衍生物的色谱分离剂。 该新型多糖衍生物具有优异的耐溶剂性，可用作通过色谱手性拆分手性化合物的分离剂。 本发明的方法有效地提供了新型多糖衍生物。