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公开(公告)号：US12050156B2
公开(公告)日：2024-07-30
申请号：US18556235
申请日：2022-04-14
发明人： Florian Blake , Frederic Bazin , Shahmir Fatherazi , Michael Braun , Nicolas Thevenin , Marc Hogreve
CPC分类号： G01M3/223 , F16J15/022 , G01N33/0009
摘要： The sealing arrangement includes a connecting device and one or more housing parts of a housing unit for enclosing of a component, typically an attachment component forming a head of the connecting device. The gas permeable end formed in such component can be isolated, so that the sealing arrangement is adapted for use in detecting a detectable gas in a hermetically sealed detection chamber. Thanks to a sealing structure configured at a passageway for the fastening of the connecting device, a housing unit is obtained with a tight radial contact around an intermediate portion of the connecting device. The device is fitted with a flexible hose end, preferably at a barbed nozzle forming the end at the opposite from the gas permeable end. With such arrangement, the hose mounting can be tested for its integrity.
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公开(公告)号：US11844746B2
公开(公告)日：2023-12-19
申请号：US16495729
申请日：2018-03-28
发明人： Stephane Baud , Frédéric Bazin
CPC分类号： A61J1/10 , A61J1/16 , B65D43/022 , B32B2323/04 , B65D21/0223 , B65D21/0233 , B65D21/0234 , B65D77/06 , B65D2543/00296 , B65D2543/00324
摘要： The invention relates to a protective housing for a biopharmaceutical liquid bag having a lower shell with a bottom and side walls, and an upper shell. The upper shell includes a housing for receiving the bag, and can be inserted into the lower shell, in such a way that the opening of the housing is adjacent to and facing the bottom of the lower shell, and in such a way that the upper shell is laterally held in place between the side walls of the lower shell.
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3.发明公开公开(公告)号：US20230286681A1
公开(公告)日：2023-09-14
申请号：US18303036
申请日：2023-04-19
发明人： Isabelle GAY , Nicolas MENDYK
摘要： A sterile filling unit, of a basic container with contents that can be distributed in a fluid form and that is originally located in a source container in a sterile manner, includes a sterile chamber with at least one sterile entry port and/or outlet; a sterile fluid transfer and filling line with an intake and an outlet, such that for a filling stage the line passes through the wall of the sterile chamber in a sterile manner, with the intake located outside of the sterile chamber in sterile fluid communication with the source container, with the filling element at the outlet located inside the sterile chamber and positioned to be operating; and a unit that can introduce the disposable internal elements that, in a stage prior to the filling stage, were located outside of the sterile chamber, into the interior of the sterile chamber in a sterile manner.
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公开(公告)号：US10850088B2
公开(公告)日：2020-12-01
申请号：US14901545
申请日：2014-06-24
发明人： Florian Blake , Jeremy Gibelin
IPC分类号： F16L33/025 , A61M39/28 , A61M39/10 , F16L33/22 , F16L37/098 , A61M39/12 , F16L37/084 , A61J1/14
摘要： A fluid-connection device capable of and intended for connecting a flexible pipe to a flexible or rigid pipe or enclosure in a biopharmaceutical assembly such as to provide fluid communication between two fluid spaces, including a first connector in fluid communication with the first fluid space, a second connector in fluid communication with the second fluid space, the first connector and the second connector optionally being coupled together in a coupling position, the first connector including a tubular nozzle which can be inserted in one end of the pipe, a pipe clamp being arranged around the end of the tube in order to clamp the pipe onto the tubular nozzle of the first connector, the second connector including protection elements which, in the coupling position, are positioned radially at least partially opposite the pipe clamp, whereby the pipe clamp cannot come into direct contact with external elements.
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公开(公告)号：US10702838B2
公开(公告)日：2020-07-07
申请号：US16504612
申请日：2019-07-08
摘要： A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.
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公开(公告)号：US10557580B2
公开(公告)日：2020-02-11
申请号：US14784609
申请日：2014-04-10
发明人： Nicolas Mendyk
IPC分类号： F16L37/098 , A61M39/10 , F16L37/084 , F16L21/08
摘要： A fluid connection device (10) for connecting two fluid conduits (11, 12), includes a female plug (1), a male plug (2), intended to be inserted into the female plug into a final coupling position, a movable primary locking device (3), having a locked position (30) in which it prevents the male and female plugs from being released from the final coupling position, and a movable secondary latch (4) having an active position (40) designed to prevent the primary locking device (3) from being moved out of the locked position of same, whereby the fluid connection device can establish a permanent connection of the first and second conduits.
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7.发明申请公开(公告)号：US20190329197A1
公开(公告)日：2019-10-31
申请号：US16504612
申请日：2019-07-08
摘要： A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.
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公开(公告)号：US10456761B2
公开(公告)日：2019-10-29
申请号：US15750048
申请日：2016-08-02
摘要： A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.
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公开(公告)号：US10139025B2
公开(公告)日：2018-11-27
申请号：US15118794
申请日：2015-02-11
发明人： Florian Blake , Jeremy Gibelin
IPC分类号： F16L37/084 , F16B21/18
摘要： A female connector (1) configured to receive a male connector (2), having an annular exterior retaining rim (24), the female connector including a body (10), and a transverse slide (4) forming a housing, the housing (4) including two lateral grooves (41,42), the female connector including a separate deformable locking ring (3) capable of being inserted in the housing and of locking the male connector in the coupling position, the locking ring including two first concave arched portions (31), as viewed from the axis, and two second arched portions (32), with inverse curvature, i.e. convex when viewed from the axis, the second arched portions being capable of flexing towards the exterior during insertion of the male connector and capable of abutting on the external annular retaining rim and preventing withdrawal of the male connector, whereby after locking of the male connector in the female connector a definitive locking is obtained.
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公开(公告)号：US10005052B2
公开(公告)日：2018-06-26
申请号：US14472416
申请日：2014-08-29
发明人： Frederic Bernard , Eric Chevalier
CPC分类号： B01F15/0085 , B01F7/162 , B01F15/00831 , B01F2215/0032 , B65D83/0055 , C12M23/00 , C12M23/14 , C12M27/02
摘要： A processing receptacle for a biopharmaceutical product includes a pocket configured to accommodate the biopharmaceutical product that can assume a flat-folded state, an expanded state, or any intermediate state in between, a processing element having an active inner portion, a rigid protective chamber to protect the processing element, and at least one opening for introducing the product into the receptacle and/or for draining the contents from the receptacle. A portion of the protective chamber is rigidly attached to a portion of the pocket and movement of the pocket up or down brings about movement of the protective chamber; the processing element and the protective chamber are arranged to be independent from one another relative to their movements. The protective chamber has a variable height that automatically adapts to accommodate the flat-folded, expanded, or intermediate state of the pocket, and in each state of the pocket, the processing element is offset from the side walls and the upper end portion of the pocket, while being adjacent to the lower end portion. A device having such a processing receptacle and a method for processing a biopharmaceutical product utilizing such a device are also presented.
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