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公开(公告)号：US20240238697A1
公开(公告)日：2024-07-18
申请号：US18014392
申请日：2021-12-20
发明人： M. Balamurugan , N. K. Pandey , Shekhar Kumar , J. B. Joshi
IPC分类号： B01D11/04
CPC分类号： B01D11/0457 , B01D11/048
摘要： This disclosure relates to an annular centrifugal extractor with Solid Separation Part to Separate Solid Particles Present in Solvent Extraction Fluid. In order to remove solid particles from the solution, a solid separation part/rotating bowl is attached to rotating bowl in such a way that solid particles settle inside the solid separation part. This solid separating centrifugal extractor contains two parts: (I) upper part which acts as a liquid-liquid separator to separate aqueous and organic solution used in solvent extraction operation and (II) bottom part which acts as a solid separator to separate solid particle present in solvent extraction liquids. The bottom rotating rotor is coupled with upper rotating rotor by threading arrangement. Both the rotating rotors are confined within a stationary cylinder. Dispersion with solid particles entering inside the rotating bowl is deflected towards the wall of the rotating cylinder by deflecting baffle by centrifugal sedimentation.
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2.发明公开公开(公告)号：US20240208901A1
公开(公告)日：2024-06-27
申请号：US18087427
申请日：2022-12-22
发明人： Amit Kunwar , Manoj K. Pal , Vishwa Vipulkumar Gandhi , Sandip Dey , Ram Pada Das , Beena Gobind Singh , Amey P. Wadawale
IPC分类号： C07C391/00
CPC分类号： C07C391/00 , C07B2200/05
摘要： The present invention applies to a deuterated derivative of 3,3′-diselenodipropionic acid (D-DSePA), an organo-selenium compound and method of synthesis thereof. The invention also provides the method including D-DSePA for the inhibition of the proliferation of human non-small cell lung carcinoma (NSCLC) cells. This compound inhibits the proliferation of A549, H1975 and H3122 cells of NSCLC origin at a much lower concentration than that needed to inhibit the growth of non-cancerous lung fibroblast cells (WI-38 and WI-26 VA4). Further, D-DSePA exhibits additive effect in A549 lung cancer cells while protecting non-cancerous WI38 cells from radiotoxicity.
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公开(公告)号：US10918695B2
公开(公告)日：2021-02-16
申请号：US16239280
申请日：2019-01-03
发明人： Deepak Sharma , Santosh Kumar Sandur , Maikho Thoh , Raghavendra Shridhar Patwardhan , Dharmendra K. Maurya , Rahul Checker , Vikram P. Gota , Jayakumar Sundarraj , Haldhar Dev Sarma , Subrata Chattopadhyay
摘要： A method of treatment of disease condition resulting from deficiency of hematopoietic stem and progenitor cells and/or epidermal stem cells in skin comprising: administering to the subject suffering from said disease conditions, an effective amount of Jack bean lectin or a pharmaceutically acceptable salt thereof for increasing the abundance of hematopoietic stem cells and progenitor cells in bone marrow and/or epidermal stem cells in skin in vivo. Method of treating said conditions in a subject involves administering a single injection of lectin in a dose range of 0.5-2.0 mg/kg body weight to mouse leading to 2.815 to 3.55 fold increase in the abundance of epidermal stem cells in skin and a dose range of 8.0-10.0 mg/Kg body weight to a mouse leading to 2.36 to 6.67-fold increase in the abundance of hematopoietic stem and progenitor cells in bone marrow.
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公开(公告)号：US20200215152A1
公开(公告)日：2020-07-09
申请号：US16239280
申请日：2019-01-03
发明人： Deepak Sharma , Santosh Kumar Sandur , Maikho Thoh , Raghavendra Shridhar Patwardhan , Dharmendra K. Maurya , Rahul Checker , Vikram P. Gota , Jayakumar Sundarraj , Haldhar Dev Sarma , Subrata Chattopadhyay
摘要： Use of Jack bean lectin or a pharmaceutically acceptable salt thereof for increasing the abundance of hematopoietic stem cells and progenitor cells in bone marrow and/or epidermal stem cells in skin in vivo and a method of treatment involving the said lectin at a specific dose to treat conditions due to depletion of stem cells. Method of treating said conditions in a subject by administering a single injection of lectin dose 0.5-2.0 mg/kg body weight to mouse for increasing the abundance of skin stem cells from 2.815±0.100% (mean±SEM) in control untreated mice to 8.097±0.938% and 9.993±0.542% in mice treated with lectin dose of 0.5 mg/kg body weight and 2 mg/kg body weight respectively; and a dose range 8.0-10 mg/kg body weight to mouse for increasing the abundance of hematopoietic stem cells in bone marrow from 0.293±0.043% (mean±SEM) in control untreated mice to 1.956±0.592% and 0.692±0.193% in mice treated with lectin dose of 8.0 mg/kg body weight and 10 mg/kg body weight respectively.
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5.发明授权公开(公告)号：US10101467B2
公开(公告)日：2018-10-16
申请号：US15234064
申请日：2016-08-11
发明人： Sanjay Kher , Smita Chaubey , Jai Kishore , Srikant M. Oak
IPC分类号： G01T1/02
摘要： This invention relates to a sensor device consisting of long period gratings made of rare-earth doped double clad fiber, which is written by CO2 laser irradiation while the fiber is held static, for gamma dose measurement in the range of 150 Gy-2.5 kGy, extendable to 20 kGy, which measurements are real-time and can be from remote locations. The sensor device has high wavelength dip shift sensitivity of at least 2.8 nm/kGy, and its radiation-induced changes are near permanent. The gratings demonstrate negligible temperature sensitivity and the shifts recorded show negligible annealing at room temperature.
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公开(公告)号：US20170117089A1
公开(公告)日：2017-04-27
申请号：US15301802
申请日：2014-06-13
CPC分类号： H01F27/2823 , H01F27/02 , H01F27/29 , H01F27/324 , H01F30/08 , H01F2005/006 , H03B11/02 , H03K3/537
摘要： An arrangement of coaxial windings is provided. The arrangement includes primary and secondary windings as air-core pulse transformers having insulation and winding arrangement for efficient energy transfer to the secondary winding. The secondary winding is wound with a central metallic core to include a coaxial transmission line with it and is configured to deliver a rectangular pulse across its terminals. The arrangement also includes a coaxial feeding arrangement for the primary winding with a central coaxial terminal connecting to one end of an adjustable primary closing switch electrode so as to have variable voltage feed input corresponding to its load requirement.
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公开(公告)号：US20170006695A1
公开(公告)日：2017-01-05
申请号：US15022358
申请日：2015-03-02
摘要： The present invention relates to method and device invention made in SS316LN for tuning single-cell or multi-cell SCRF cavity for precise slow and fast tuning with low hysteresis. The tuning mechanism (device) for SCRF cavity consists of two thick square flanges connected to each other through two parallel sets of X-link levers pivoted in between such that the motion of top end of flange and bottom end of flange equalizes; wherein the top end of X-link connects one square flange to the bottom end of the other square flange and vice-versa using thin flat flexure plates; wherein the flexure plates are joined on X-link and square flange by bolts having spring locks; the square flanges have platform on the top that transfer motion and these are connected through power screw mechanism; wherein the power screw for linear actuation is rotated using worm-wheel.
摘要翻译： 本发明涉及用于调谐单电池或多电池SCRF腔的SS316LN中的方法和装置发明，用于具有低滞后的精确的慢速和快速调谐。 用于SCRF腔的调谐机构（装置）包括两个通过两个平行组合的X形连杆杆彼此连接的厚方形凸缘，这两组平行组合在其间枢转，使得凸缘顶端和凸缘底端的运动相等; 其中X形连杆的顶端将一个方形凸缘连接到另一个方形凸缘的底端，反之亦然，使用薄平板挠曲板; 其中所述弯曲板通过具有弹簧锁的螺栓在X形连杆和方形凸缘上接合; 方形法兰在顶部具有传递运动的平台，这些平台通过动力螺丝机构连接; 其中用于线性致动的动力螺杆使用蜗轮转动。
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公开(公告)号：US20220305023A1
公开(公告)日：2022-09-29
申请号：US17214450
申请日：2021-03-26
发明人： Deepak Sharma , Santosh Kumar Sandur , Vikram Prakash Gota , Raghavendra Shridhar Patwardhan , Babita Singh , Rahul Checker , Dharmendra Kumar Maurya , Mahendra Joshi , Amarjit Giri , Shivkumar Madki , Sudeep Gupta
IPC分类号： A61K31/555 , A61K9/28 , A61P37/04 , A61P31/14
摘要： Pharmaceutical composition comprises of Chlorophyllin or salts thereof and its utilities including method of treatment, enabling the absorption of Copper-isochlorin e4 into human blood that results in an increase in lymphocyte count and decrease in the abundance of hematopoietic stem and progenitor cells (HPSCs) in human blood. The invention is directed to the treatment of conditions including corona-virus infection, immunosuppression, leucopenia and lymphopenia. The composition disclosed in the invention is thus useful for the treatment of corona virus disease caused by SARS-CoV-2 infection by decreasing viral infection, reducing cytokine storm and pro-inflammatory chemokines, reducing epithelial-cell oxidative-stress in the lungs and increasing the production of leukocytes.
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公开(公告)号：US11213499B1
公开(公告)日：2022-01-04
申请号：US17003420
申请日：2020-08-26
发明人： Amit Kunwar , Vishwa Vipulkumar Gandhi , Khushboo Atulkumar Gandhi , Vikram Suryaprakash Gota , Jayant Sastri Goda , Jyoti Anand Kode , Liladhar Baburao Kumbhare , Vimal Kumar Jain , Kavirayani Indira Priyadarsini
IPC分类号： A61K31/194 , A61P35/00
摘要： The present invention describes the method of using a synthetic organoselenium compound, DSePA for management of non-small cell lung carcinoma (NSCLC) and chronic myelogenous leukemia (CML). The method comprises administering DSePA orally at a dosage of 1 mg/Kg body weight daily for inhibiting the growth of A549 (representative of NSCLC) and K562 (representative of CML) tumor in mice models. Additionally, the said compound also inhibits the proliferation of other cancer cells of NSCLC (HOP-62 and H460), breast (MDA-MB-231), white blood cells (JURKAT and U-937), oral (SCC-40), colon (HT-29), kidney (A498) and cervix (SiHA) origins in cellular models at a much lower concentration than that needed to inhibit the growth of normal cells.
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公开(公告)号：US20210354240A1
公开(公告)日：2021-11-18
申请号：US16999814
申请日：2018-02-24
发明人： Brahma Nand UPADHYAYA , Pusbkar MISRA , Suresh Chandra VISHWAKARMA , Raiesh ARYA , Srikant M. OAK , Purushottam Das GUPTA
摘要： An improved laser welding method of materials by means of long pulse and high energy pulses of solid state lasers in such a manner that large depth of penetration with full depth or partial depth of penetration can be achieved with minimum surface evaporation in first pass of laser beam and enhanced surface smoothness having average surface smoothness of 5 mm by second pass of laser beam of lower power density and inclined at a particular inclination.
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