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公开(公告)号：US10131633B2
公开(公告)日：2018-11-20
申请号：US15841652
申请日：2017-12-14
Inventor： Yuta Suzuki , Kenji Hyodo , Yohei Tanaka
IPC: C07D207/16 , C07D211/62 , A61K47/22 , A61K9/51 , C07D205/04 , C12N15/11 , A61K48/00 , C12N15/113
Abstract: The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of physical stability of a lipid complex. This cationic lipid is a compound represented by the general formula (3) or a pharmaceutically acceptable salt thereof: wherein, L is an alkyl having 7-12 carbon atoms or an alkenyl having 7-12 carbon atoms, R is an alkyl having 1-2 carbon atoms, and n1 and n2 are independently an integer of 1-3.
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公开(公告)号：US20170334852A1
公开(公告)日：2017-11-23
申请号：US15533576
申请日：2015-12-24
Inventor： Yuta Suzuki , Kenji Hyodo , Yohei Tanaka
IPC: C07D211/62 , C12N15/113 , A61K47/10 , A61K31/713 , A61K47/22 , A61K47/28 , C07C229/12
CPC classification number: C07D211/62 , A61K31/713 , A61K47/10 , A61K47/22 , A61K47/28 , C07C229/06 , C07C229/12 , C12N15/09 , C12N15/113 , C12N15/1137 , C12N2310/14
Abstract: The present invention provides a cationic lipid which can be utilized for nucleic acid delivery into the cytoplasm. The cationic lipid of the present invention is, for example, a compound represented by the following Formula (1) or a pharmaceutically acceptable salt thereof.
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Patent Agency Ranking
公开(公告)号：US20240148664A1
公开(公告)日：2024-05-09
申请号：US18285991
申请日：2022-04-11
Inventor： Tetsuo KOANA , Jun HAYASHIDA , Toshinori TAKAKI , Yohei TANAKA , Nahoko OZAKI , Tomohiro ASAI
CPC classification number: A61K9/5123 , A61K47/44
Abstract: Provided are a lipid and a composition that can effectively deliver an introduction compound such as a nucleic acid to a target cell, tissue, or the like in vivo. The lipid of the present invention is a lipid represented by the following formula (I), wherein R1 is a hydrocarbon group having 32 to 48 carbon atoms, R2 is a side chain of one arbitrary amino acid or a side chain of a derivative of the amino acid, and R3 is a side chain of a basic amino acid or a side chain of a derivative of the amino acid,
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公开(公告)号：US10081598B2
公开(公告)日：2018-09-25
申请号：US15533576
申请日：2015-12-24
Inventor： Yuta Suzuki , Kenji Hyodo , Yohei Tanaka
IPC: A61K31/713 , C07D211/62 , C12N15/113 , C07C229/06 , A61K47/10 , A61K47/22 , A61K47/28 , C07C229/12 , C12N15/09
CPC classification number: C07D211/62 , A61K31/713 , A61K47/10 , A61K47/22 , A61K47/28 , C07C229/06 , C07C229/12 , C12N15/09 , C12N15/113 , C12N15/1137 , C12N2310/14
Abstract: The present invention provides a cationic lipid which can be utilized for nucleic acid delivery into the cytoplasm. The cationic lipid of the present invention is, for example, a compound represented by the following Formula (1) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20160326116A1
公开(公告)日：2016-11-10
申请号：US15109512
申请日：2015-01-07
Inventor： Yuta Suzuki , Kenji Hyodo , Yohei Tanaka
IPC: C07D211/62 , A61K48/00 , C12N15/113 , C07D207/16 , C07D205/04
CPC classification number: C07D211/62 , A61K9/5123 , A61K47/22 , A61K48/0033 , C07D205/04 , C07D207/16 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32
Abstract: The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of physical stability of a lipid complex. This cationic lipid is a compound represented by the general formula (3) or a pharmaceutically acceptable salt thereof: wherein, L is an alkyl having 7-12 carbon atoms or an alkenyl having 7-12 carbon atoms, R is an alkyl having 1-2 carbon atoms, and n1 and n2 are independently an integer of 1-3.
Abstract translation: 其中，L是具有7-12个碳原子的烷基或具有7-12个碳原子的烯基，R是具有1-2个碳原子的烷基，n1和n2独立地是1-3的整数。
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公开(公告)号：US20180105493A1
公开(公告)日：2018-04-19
申请号：US15841652
申请日：2017-12-14
Inventor： Yuta Suzuki , Kenji Hyodo , Yohei Tanaka
IPC: C07D211/62 , C12N15/113 , A61K48/00 , A61K47/22 , C07D207/16 , C07D205/04 , A61K9/51 , C12N15/11
CPC classification number: C07D211/62 , A61K9/5123 , A61K47/22 , A61K48/0033 , C07D205/04 , C07D207/16 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32
Abstract: The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of physical stability of a lipid complex. This cationic lipid is a compound represented by the general formula (3) or a pharmaceutically acceptable salt thereof: wherein, L is an alkyl having 7-12 carbon atoms or an alkenyl having 7-12 carbon atoms, R is an alkyl having 1-2 carbon atoms, and n1 and n2 are independently an integer of 1-3.
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公开(公告)号：US09873669B2
公开(公告)日：2018-01-23
申请号：US15109512
申请日：2015-01-07
Inventor： Yuta Suzuki , Kenji Hyodo , Yohei Tanaka
IPC: C07D211/62 , A61K47/22 , A61K9/51 , C07D205/04 , C07D207/16 , C12N15/11 , A61K48/00 , C12N15/113
CPC classification number: C07D211/62 , A61K9/5123 , A61K47/22 , A61K48/0033 , C07D205/04 , C07D207/16 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32
Abstract: The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of physical stability of a lipid complex. This cationic lipid is a compound represented by the general formula (3) or a pharmaceutically acceptable salt thereof: wherein, L is an alkyl having 7-12 carbon atoms or an alkenyl having 7-12 carbon atoms, R is an alkyl having 1-2 carbon atoms, and n1 and n2 are independently an integer of 1-3.
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