公开(公告)号：US07838707B2

公开(公告)日：2010-11-23

申请号：US11947950

申请日：2007-11-30

Applicant: Jennifer Ellen McCusker-Orth ,  Jerome Leonard Stavinoha, Jr. ,  Anthony Dominick Messina ,  Steven Thomas Perri ,  Zhufang Liu ,  Philip Conrad Heidt ,  Brent Alan Tennant

Inventor： Jennifer Ellen McCusker-Orth ,  Jerome Leonard Stavinoha, Jr. ,  Anthony Dominick Messina ,  Steven Thomas Perri ,  Zhufang Liu ,  Philip Conrad Heidt ,  Brent Alan Tennant

IPC: C07C35/04

CPC classification number: C07C29/145 ,  C07B2200/09 ,  C07C45/72 ,  C07C45/89 ,  C07C45/90 ,  C07C49/88 ,  C07C2601/04 ,  C07C49/39 ,  C07C35/045

Abstract: The present disclosure relates to the production of a 2,2,4,4-tetraalkylcyclobutane-1,3-diol. In one embodiment, the present invention relates to the production of a 2,2,4,4-tetraalkylcyclobutane-1,3-diol by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione in the presence of a ruthenium-promoted cobalt-based catalyst.

Abstract translation: 本公开涉及制备2,2,4,4-四烷基环丁烷-1,3-二醇。 在一个实施方案中，本发明涉及在存在下通过氢化2,2,4,4-四烷基环丁烷-1,3-二酮制备2,2,4,4-四烷基环丁烷-1,3-二醇 的钌促进的钴基催化剂。

公开(公告)号：US20080132739A1

公开(公告)日：2008-06-05

申请号：US11948047

申请日：2007-11-30

Applicant: Jennifer Ellen McCusker-Orth ,  Jerome Leonard Stavinoha ,  Anthony Dominick Messina ,  Steven Thomas Perri ,  Zhufang Liu ,  Philip Conrad Heidt ,  Brent Alan Tennant

Inventor： Jennifer Ellen McCusker-Orth ,  Jerome Leonard Stavinoha ,  Anthony Dominick Messina ,  Steven Thomas Perri ,  Zhufang Liu ,  Philip Conrad Heidt ,  Brent Alan Tennant

IPC: C07C29/145

CPC classification number: C07C29/145 ,  C07C45/72 ,  C07C45/89 ,  C07C45/90 ,  C07C49/88 ,  C07C2601/04 ,  C07C31/20 ,  C07C49/39

Abstract: The present invention relates to the production of 2,2,4,4-tetramethylcyclobutane-1,3-diol. In one embodiment, the present invention relates to the production of 2,2,4,4-tetramethylcyclobutane-1,3-diol by hydrogenation of 2,2,4,4-tetramethylcyclobutane-1,3-dione in the presence of a cobalt-based catalyst.

Abstract translation: 本发明涉及2,2,4,4-四甲基环丁烷-1,3-二醇的制备。 在一个实施方案中，本发明涉及通过在2,2'-四甲基环丁烷-1,3-二醇的存在下氢化2,2,4,4-四甲基环丁烷-1,3-二酮来制备2,2,4,4-四甲基环丁烷-1,3-二醇 钴基催化剂。

公开(公告)号：US06670505B1

公开(公告)日：2003-12-30

申请号：US09519936

申请日：2000-03-07

Applicant: Nick Allen Collins ,  Mark Robert Shelton ,  George William Tindall ,  Steven Thomas Perri ,  Ruairi Seosamh O'Meadhra ,  Chester Wayne Sink ,  Bhaskar Krishna Arumugam ,  John Clark Hubbs

Inventor： Nick Allen Collins ,  Mark Robert Shelton ,  George William Tindall ,  Steven Thomas Perri ,  Ruairi Seosamh O'Meadhra ,  Chester Wayne Sink ,  Bhaskar Krishna Arumugam ,  John Clark Hubbs

IPC: C07C5142

CPC classification number: C07C51/43 ,  Y02P20/582 ,  Y10S435/803 ,  Y10S435/876 ,  Y10S435/896 ,  C07C59/347

Abstract: A process for recovering a desired organic acid from a solution includes the steps of: providing an aqueous solution including at least one desired organic acid or its acid anion; adjusting the proton concentration in the aqueous solution to a desired level, with the desired proton concentration being selected, at least in part, by the amount of available protons needed to associate with the acid anions of the desired organic acid(s) to be recovered and/or acid anions that are weaker than the desired organic acids; and recovering at least a portion of the at least one desired organic acid from the aqueous phase. The desired proton concentration can be based on the amount of available protons being greater than, less than or substantially equal, to the amount of protons needed to associate with the anion of the desired organic acid(s) and acid anions that are weaker than the desired organic acid(s). Specific examples of suitable organic acids include, but are not limited to, ascorbic, succinic, tartaric, glyconic, gulonic, citric, lactic, hialic, maleic, acetic, formic, gluconic pyruvic, propionic, butyric, itaconic acids and mixtures thereof. One embodiment of the present invention relates to the recovery of 2-keto-L-gulonic acid (KLG) from aqueous solutions such as fermentation baths.

Abstract translation: 从溶液中回收所需有机酸的方法包括以下步骤：提供包含至少一种所需有机酸或其酸阴离子的水溶液; 将所述水溶液中的质子浓度调节到所需的水平，其中所需质子浓度至少部分地被选择与需要回收的所需有机酸的酸性阴离子缔合所需的可用质子的量 和/或弱于所需有机酸的酸性阴离子; 以及从所述水相中回收所述至少一种所需有机酸的至少一部分。 期望的质子浓度可以基于可用质子的量大于，小于或基本上等于与所需有机酸的阴离子和酸阴离子相比所需的质子的量，其弱于 合适的有机酸的具体实例包括但不限于抗坏血酸，琥珀酸，酒石酸，葡萄糖酸，古洛糖酸，柠檬酸，乳酸，唾液酸，马来酸，乙酸，甲酸，葡萄糖酸，丙酸，丙酸，丁酸， 衣康酸及其混合物。 本发明的一个实施方案涉及从水溶液如发酵浴中回收2-酮-L-古洛糖酸（KLG）。

公开(公告)号：US06518454B1

公开(公告)日：2003-02-11

申请号：US09975872

申请日：2001-10-12

Applicant: Bhaskar Krishna Arumugam ,  Larry Wayne Blair ,  Brendan William Boyd ,  Nick Allen Collins ,  David Anthony Larkin ,  Steven Thomas Perri ,  Chester Wayne Sink

Inventor： Bhaskar Krishna Arumugam ,  Larry Wayne Blair ,  Brendan William Boyd ,  Nick Allen Collins ,  David Anthony Larkin ,  Steven Thomas Perri ,  Chester Wayne Sink

IPC: C07C6702

CPC classification number: C07C67/08 ,  C07C69/68 ,  C07C69/716

Abstract: Disclosed is a process wherein a solution of a carboxylic acid in a first solvent and an alcohol are fed to a simulated moving bed reactor (SMBR) containing a solid(s) to produce a first stream comprising a solution of an ester of the carboxylic acid and the alcohol and a second stream comprising the first solvent. The solid(s) present in the SMBR facilitates the esterification reaction and the separation of the first solvent from the carboxylic acid. The process is particularly valuable for the preparation of an alkanol solution of an alkyl 2-keto-L-gulonate ester (AKLG) from an aqueous fermentation broth containing dissolved 2-keto-L-gulonic acid (KLG) by feeding the fermentation broth and an alkanol to a simulated moving bed reactor which contains a solid acidic esterification catalyst to produce a stream comprising an alkanol solution of an ALKG. The alkanol solution of an ALKG may be used directly to convert the ALKG to ascorbic acid (Vitamin C).

Abstract translation: 公开了一种方法，其中将羧酸在第一溶剂和醇中的溶液进料到含有固体的模拟移动床反应器（SMBR）中以产生包含羧酸的酯溶液的第一物流 所述醇和包含所述第一溶剂的第二物流。 存在于SMBR中的固体促进酯化反应和第一溶剂与羧酸的分离。 该方法对于通过加入发酵液从含有溶解的2-酮-L-古洛糖酸（KLG）的水性发酵液中制备2-酮-L-古洛糖酸烷基酯（AKLG）的链烷醇溶液是特别有价值的， 将链烷醇加入到含有固体酸性酯化催化剂以产生包含ALKG的链烷醇溶液的流的模拟移动床反应器中。 ALKG的链烷醇溶液可以直接用于将ALKG转化为抗坏血酸（维生素C）。

公开(公告)号：US06476239B1

公开(公告)日：2002-11-05

申请号：US10074829

申请日：2002-02-12

Applicant: Bhaskar Krishna Arumugam ,  Steven Thomas Perri ,  Elaine Beatrice Mackenzie ,  Larry Wayne Blair ,  Joseph Robert Zoeller

Inventor： Bhaskar Krishna Arumugam ,  Steven Thomas Perri ,  Elaine Beatrice Mackenzie ,  Larry Wayne Blair ,  Joseph Robert Zoeller

IPC: C07D30762

CPC classification number: C07D307/62

Abstract: The present invention is a process for the preparation of ascorbic acid using a simulated moving bed (SMB) reactor system to accomplish the simultaneous conversion of KLG or a derivative of KLG to ascorbic acid and the separation of reaction products. The SMB reactor contains a solid or mixture of solids effective for catalyzing the reaction of KLG or its derivative and for separating the reactions products by selective adsorption of at least one product. In a general embodiment, this process involves (1) feeding a solution of KLG or a derivative thereof in a first solvent and a desorbent which is miscible with the first solvent, to a simulated moving bed reactor; (2) reacting the KLG or the KLG derivative to form ascorbic acid; and (3) removing from the simulated moving bed reactor (i) a first liquid stream comprising a solution of ascorbic acid in the desorbent and the first solvent (ii) a second liquid stream comprising the first solvent and the desorbent.

Abstract translation: 本发明是使用模拟移动床（SMB）反应器系统制备抗坏血酸的方法，以实现KLG或KLG的衍生物同时转化为抗坏血酸和分离反应产物。 SMB反应器含有对催化KLG或其衍生物的反应有效的固体或固体混合物，并且通过选择性吸附至少一种产物来分离反应产物。 在一般实施方案中，该方法包括（1）将KLG或其衍生物的溶液送入模拟移动床反应器中的第一溶剂和可与第一溶剂混溶的解吸剂; （2）使KLG或KLG衍生物反应形成抗坏血酸; （3）从模拟移动床反应器（i）中除去包含解吸剂中的抗坏血酸溶液的第一液体流和第一溶剂（ii）包含第一溶剂和解吸剂的第二液体流。

公开(公告)号：US20080194398A1

公开(公告)日：2008-08-14

申请号：US11674808

申请日：2007-02-14

Applicant: SCOTT DONALD BARNICKI ,  BRUCE LEROY GUSTAFSON ,  ZHUFANG LIU ,  STEVEN THOMAS PERRI ,  PAUL RANDOLPH WORSHAM

Inventor： SCOTT DONALD BARNICKI ,  BRUCE LEROY GUSTAFSON ,  ZHUFANG LIU ,  STEVEN THOMAS PERRI ,  PAUL RANDOLPH WORSHAM

IPC: B01J31/00

CPC classification number: C07C29/157 ,  B01J23/868 ,  B01J23/8993 ,  B01J37/0205 ,  C07C29/149 ,  C07C2601/14 ,  Y02P20/52 ,  C07C31/04 ,  C07C31/276 ,  C07C31/08 ,  C07C31/10 ,  C07C31/12 ,  C07C31/125 ,  C07C31/205 ,  C07C31/202 ,  C07C31/207 ,  C07C31/20 ,  C07C35/08 ,  C07C31/1355 ,  C07C31/225 ,  C07C31/22

Abstract: Disclosed are catalysts comprising copper chromite, ruthenium and at least one promoter selected from alkali metals, alkaline earth metals, rare earth elements having hydrogenation activity. The combination of copper chromite with ruthenium and the alkali, alkaline earth, and/or rare earth elements enhances catalyst activity more than the addition of either type of promoter alone. The catalysts are useful for the preparation of methanol from carbon monoxide and hydrogen and for the hydrogenation of carbonyl compounds such as, for example, aldehydes, ketones, and esters, to their corresponding alcohols. The catalysts may be used for the preparation of cyclohexanedimethanols from dialkyl cyclohexanedicarboxylates or of ethylene glycol from alkyl glycolates.

Abstract translation: 公开了包含亚铬酸铜，钌和至少一种选自碱金属，碱土金属，具有氢化活性的稀土元素的助催化剂。 亚铬酸铜与钌的组合与碱金属，碱土金属和/或稀土元素的组合比单独添加任一类型的助催化剂提高了催化剂活性。 催化剂可用于从一氧化碳和氢气制备甲醇，并将羰基化合物（例如醛，酮和酯）氢化成其相应的醇。 催化剂可用于从环己烷二羧酸二烷基酯或乙二醇由烷基乙醇酸制备环己烷二甲醇。

公开(公告)号：US06610863B2

公开(公告)日：2003-08-26

申请号：US10037126

申请日：2001-12-21

Applicant: Bhaskar Krishna Arumugam ,  Nick Allen Collins ,  Transito Lynne Macias ,  Steven Thomas Perri ,  Jeffrey Earl Grant Powell ,  Chester Wayne Sink ,  Michael Roy Cushman

Inventor： Bhaskar Krishna Arumugam ,  Nick Allen Collins ,  Transito Lynne Macias ,  Steven Thomas Perri ,  Jeffrey Earl Grant Powell ,  Chester Wayne Sink ,  Michael Roy Cushman

IPC: C07D30762

CPC classification number: C07D307/62 ,  Y02P20/582

Abstract: The present invention provides methods and an apparatus for the manufacture of an L-ascorbic acid product in high yield by direct conversion of an aqueous solution containing 2-keto-L-gulonic acid by contact with an acid catalyst or under thermal self-catalyzed conditions at a conversion level that maximizes the formation of L-ascorbic acid and minimizes decomposition of the L-ascorbic acid thus formed. The separation process for L-ascorbic acid and KLG is operated in such a way that an efficient separation process allows the majority of the KLG to be recycled for further conversion. The product stream from the separation process is then subjected to a recovery step to obtain crystalline L-ascorbic acid product.

公开(公告)号：US06320061B1

公开(公告)日：2001-11-20

申请号：US09587752

申请日：2000-06-05

Applicant: Nick Allen Collins ,  Steven Thomas Perri

Inventor： Nick Allen Collins ,  Steven Thomas Perri

IPC: C07D30762

CPC classification number: C07D307/62

Abstract: A process for recovering an organic acid or a metal salt thereof includes contacting an alcoholic phase containing one or more organic acid(s) or metal salt(s) thereof with water under conditions effective to provide an aqueous phase containing a portion of the organic acid(s) or metal salt(s) thereof. The aqueous phase does not contain substantial amounts of the alcohol(s). This process can also include recovery of the organic acid(s) or metal salt(s) thereof from the aqueous phase.

Abstract translation: 回收有机酸或其金属盐的方法包括在有效提供含有一部分有机酸的水相的条件下使含有一种或多种有机酸或其金属盐的醇相与水接触 或其金属盐。 水相不含大量的醇。 该方法还可以包括从水相中回收有机酸或其金属盐。

公开(公告)号：US07521583B2

公开(公告)日：2009-04-21

申请号：US11948047

申请日：2007-11-30

Applicant: Jennifer Ellen McCusker-Orth ,  Jerome Leonard Stavinoha, Jr. ,  Anthony Dominick Messina ,  Steven Thomas Perri ,  Zhufang Liu ,  Philip Conrad Heidt ,  Brent Alan Tennant

Inventor： Jennifer Ellen McCusker-Orth ,  Jerome Leonard Stavinoha, Jr. ,  Anthony Dominick Messina ,  Steven Thomas Perri ,  Zhufang Liu ,  Philip Conrad Heidt ,  Brent Alan Tennant

IPC: C07C35/04

CPC classification number: C07C29/145 ,  C07C45/72 ,  C07C45/89 ,  C07C45/90 ,  C07C49/88 ,  C07C2601/04 ,  C07C31/20 ,  C07C49/39

Abstract: The present invention relates to the production of 2,2,4,4-tetramethylcyclobutane-1,3-diol. In one embodiment, the present invention relates to the production of 2,2,4,4-tetramethylcyclobutane-1,3-diol by hydrogenation of 2,2,4,4-tetramethylcyclobutane-1,3-dione in the presence of a cobalt-based catalyst.

Abstract translation: 本发明涉及2,2,4,4-四甲基环丁烷-1,3-二醇的制备。 在一个实施方案中，本发明涉及通过在2,2'-四甲基环丁烷-1,3-二醇的存在下氢化2,2,4,4-四甲基环丁烷-1,3-二酮来制备2,2,4,4-四甲基环丁烷-1,3-二醇 钴基催化剂。

公开(公告)号：US20080154069A1

公开(公告)日：2008-06-26

申请号：US11947950

申请日：2007-11-30

Applicant: Jennifer Ellen McCusker-Orth ,  Jerome Leonard Stavinoha ,  Anthony Dominick Messina ,  Steven Thomas Perri ,  Zhufang Liu ,  Philip Conrad Heidt ,  Brent Alan Tennant

Inventor： Jennifer Ellen McCusker-Orth ,  Jerome Leonard Stavinoha ,  Anthony Dominick Messina ,  Steven Thomas Perri ,  Zhufang Liu ,  Philip Conrad Heidt ,  Brent Alan Tennant

IPC: C07C35/04

CPC classification number: C07C29/145 ,  C07B2200/09 ,  C07C45/72 ,  C07C45/89 ,  C07C45/90 ,  C07C49/88 ,  C07C2601/04 ,  C07C49/39 ,  C07C35/045

Abstract: The present disclosure relates to the production of a 2,2,4,4-tetraalkylcyclobutane-1,3-diol. In one embodiment, the present invention relates to the production of a 2,2,4,4-tetraalkylcyclobutane-1,3-diol by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione in the presence of a ruthenium-promoted cobalt-based catalyst.

Abstract translation: 本公开涉及制备2,2,4,4-四烷基环丁烷-1,3-二醇。 在一个实施方案中，本发明涉及在存在下通过氢化2,2,4,4-四烷基环丁烷-1,3-二酮制备2,2,4,4-四烷基环丁烷-1,3-二醇 的钌促进的钴基催化剂。