Abstract:
This disclosure relates to an angiogenesis-related pharmaceutical composition using connective tissue growth factor, more particularly to a pharmaceutical composition for promoting angiogenesis containing the connective tissue growth factor or a pharmaceutical composition for inhibiting angiogenesis containing at least one selected from the group consisting of polypeptide, antibody and a compound binding to connective tissue growth factor. The fragment of connective tissue growth factor protein, which was found out in the present invention, is a binding region to FPRL1, effectively induces FPRL1-specific ERK phosphorylation, activates FPRL1 to increase intracellular Ca2+ concentration, and finally, effectively induces angiogenesis, and thus, the fragment of connective tissue growth factor may be useful for a pharmaceutical composition for promoting angiogenesis, while polypeptide, antibody or a compound binding to the fragment of connective tissue growth factor protein may be useful for a pharmaceutical composition for inhibiting angiogenesis.
Abstract:
The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
Abstract:
A semantic-based searching apparatus and method which can search for desired information from various types of media using associative properties of search target objects are provided. The semantic-based searching apparatus stores an associative search structure that previously stores a semantic index. The associative search structure is to obtain a final search object corresponding to an input search query. The semantic index configuration includes feature metadata used to identify a specific object, semantic entity metadata to indicate semantic entities corresponding to the feature metadata, and semantic relation metadata to indicate a relation between the semantic entities. The semantic-based searching apparatus uses semantic metadata stored in conformity with the semantic index configuration, the semantic index, and the associative search structure to generate a search result corresponding to the input search query.
Abstract:
The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
Abstract:
The present invention relates to an immunoregulating agent comprising a peptide, a pharmaceutical composition and a method of preventing or treating immune-related disorder such as sever sepsis or acute respiratory distress syndrome (ARDS), and the use of peptide for anti-inflammatory agent, an antibacterial agent, or an inhibiting agent of an immune cell apoptosis.
Abstract:
A method of generating relevant information related to multimedia content at a client that reproduces the multimedia content includes accessing a blog service connected to the client, selecting the first content of the multimedia content, for which relevant information is to be generated, by using the blog service, generating the relevant information using a template according to the type of the relevant information generated with respect to the first content, and transmitting the generated relevant information to a server.
Abstract:
A method of providing a slide show includes selecting one of a plurality of images in which geographic position information is set, marking a plurality of positions corresponding to the plurality of images on a map based on geographic position information and outputting the map, setting an image search range on the map based on a position on the map, which corresponds to the selected image, and providing the slide show by using images corresponding to positions on the map, which belong to the set image search range.
Abstract:
A method and apparatus for synchronizing feed information are provided. A podcasting client includes a synchronization-processing unit which synchronizes first feed information acquired from a connected device with pre-stored second feed information, and a communication interface which transmits feed information of content that is podcast based on the synchronized feed information to the connected device.
Abstract:
A method and an apparatus for providing a filtering interface that records and searches for broadcasting content is provided. A method for providing a filtering interface that records and searches for broadcasting content according to exemplary embodiments of the present invention includes analyzing user preferences for each property of the broadcasting content according to play history information of the recorded broadcasting content, generating a properties list by clustering the properties based on the user preferences, receiving a predetermined property from the properties list, extracting broadcasting content that correspond to the received properties from currently-aired or soon-to-be-aired broadcasting content, and providing a list of the extracted content.
Abstract:
The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the dendron are bound to the surface, and a terminus of the linear region of the dendron is functionalized.