利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

24 条记录 (耗时 0.026 秒)

    Pharmaceutical composition using connective-tissue growth factor
    1.
    发明授权
    Pharmaceutical composition using connective-tissue growth factor 有权
    使用结缔组织生长因子的药物组合物

    公开(公告)号：US08859496B2

    公开(公告)日：2014-10-14

    申请号：US13642143

    申请日：2011-02-21

    申请人： Sung Ho Ryu ,  Pann-Ghill Suh ,  Mi-Sook Lee ,  Wan-Uk Kim

    发明人： Sung Ho Ryu ,  Pann-Ghill Suh ,  Mi-Sook Lee ,  Wan-Uk Kim

    IPC分类号： A61K38/18

    CPC分类号： A61K38/18

    摘要： This disclosure relates to an angiogenesis-related pharmaceutical composition using connective tissue growth factor, more particularly to a pharmaceutical composition for promoting angiogenesis containing the connective tissue growth factor or a pharmaceutical composition for inhibiting angiogenesis containing at least one selected from the group consisting of polypeptide, antibody and a compound binding to connective tissue growth factor. The fragment of connective tissue growth factor protein, which was found out in the present invention, is a binding region to FPRL1, effectively induces FPRL1-specific ERK phosphorylation, activates FPRL1 to increase intracellular Ca2+ concentration, and finally, effectively induces angiogenesis, and thus, the fragment of connective tissue growth factor may be useful for a pharmaceutical composition for promoting angiogenesis, while polypeptide, antibody or a compound binding to the fragment of connective tissue growth factor protein may be useful for a pharmaceutical composition for inhibiting angiogenesis.

    摘要翻译： 本公开涉及使用结缔组织生长因子的血管生成相关药物组合物，更具体地涉及用于促进含有结缔组织生长因子的血管生成的药物组合物或用于抑制血管生成的药物组合物，其含有选自多肽， 抗体和与结缔组织生长因子结合的化合物。 在本发明中发现的结缔组织生长因子蛋白的片段是与FPRL1的结合区域，有效诱导FPRL1特异性ERK磷酸化，激活FPRL1以增加细胞内Ca2 +浓度，最终有效诱导血管生成，因此 结缔组织生长因子的片段可用于促进血管发生的药物组合物，而多肽，抗体或结合组织生长因子蛋白的片段的化合物可用于抑制血管生成的药物组合物。

    Pharmaceutical Composition Using Connective-tissue Growth Factor
    2.
    发明申请
    Pharmaceutical Composition Using Connective-tissue Growth Factor 有权
    使用结缔组织生长因子的药物组合物

    公开(公告)号：US20130039918A1

    公开(公告)日：2013-02-14

    申请号：US13642143

    申请日：2011-02-21

    申请人： Sung Ho Ryu ,  Pann-Ghill Suh ,  Mi-Sook Lee ,  Wan-Uk Kim

    发明人： Sung Ho Ryu ,  Pann-Ghill Suh ,  Mi-Sook Lee ,  Wan-Uk Kim

    IPC分类号： A61K38/18 ,  C07H21/02 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P1/04 ,  A61P17/02 ,  A61K38/02 ,  C07K16/22 ,  C07H21/00 ,  A61P37/06 ,  A61P3/10 ,  A61K48/00 ,  A61P17/06 ,  A61P35/04 ,  A61P35/00 ,  A61P29/00 ,  A61P19/02 ,  A61P13/12 ,  A61P9/12 ,  A61P27/06 ,  A61P1/16 ,  A61K31/7088 ,  A61K31/713 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/566 ,  G01N21/64 ,  A61K39/395 ,  A61P27/02 ,  C12N15/12

    CPC分类号： A61K38/18

    摘要： This disclosure relates to an angiogenesis-related pharmaceutical composition using connective tissue growth factor, more particularly to a pharmaceutical composition for promoting angiogenesis containing the connective tissue growth factor or a pharmaceutical composition for inhibiting angiogenesis containing at least one selected from the group consisting of polypeptide, antibody and a compound binding to connective tissue growth factor. The fragment of connective tissue growth factor protein, which was found out in the present invention, is a binding region to FPRL1, effectively induces FPRL1-specific ERK phosphorylation, activates FPRL1 to increase intracellular Ca2+ concentration, and finally, effectively induces angiogenesis, and thus, the fragment of connective tissue growth factor may be useful for a pharmaceutical composition for promoting angiogenesis, while polypeptide, antibody or a compound binding to the fragment of connective tissue growth factor protein may be useful for a pharmaceutical composition for inhibiting angiogenesis.

    摘要翻译： 本公开涉及使用结缔组织生长因子的血管生成相关药物组合物，更具体地涉及用于促进含有结缔组织生长因子的血管生成的药物组合物或用于抑制血管生成的药物组合物，其含有选自多肽， 抗体和与结缔组织生长因子结合的化合物。 在本发明中发现的结缔组织生长因子蛋白的片段是与FPRL1的结合区域，有效诱导FPRL1特异性ERK磷酸化，激活FPRL1以增加细胞内Ca2 +浓度，最终有效诱导血管生成，因此 结缔组织生长因子的片段可用于促进血管发生的药物组合物，而多肽，抗体或结合组织生长因子蛋白的片段的化合物可用于抑制血管生成的药物组合物。

    Immune-modulating peptide
    7.
    发明授权
    Immune-modulating peptide 有权
    免疫调节肽

    公开(公告)号：US08017572B2

    公开(公告)日：2011-09-13

    申请号：US12246229

    申请日：2008-10-06

    申请人： Sung-Ho Ryu ,  Pann-Ghill Suh ,  Yoe-Sik Bae ,  Ji-Young Song

    发明人： Sung-Ho Ryu ,  Pann-Ghill Suh ,  Yoe-Sik Bae ,  Ji-Young Song

    IPC分类号： A61K38/08 ,  C07K7/06

    CPC分类号： A61K38/08 ,  C07K7/06

    摘要： Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.

    摘要翻译： 公开了具有SEQ ID NO：1至24的肽，其诱导人单核细胞或嗜中性粒细胞产生超氧化物; 其诱导人外周血单核细胞或嗜中性粒细胞的细胞内钙增加; 结合甲酰肽受体或甲酰肽受体样1; 在体外诱导人单核细胞或嗜中性粒细胞趋化迁移; 其在表达甲酰基肽受体的细胞或甲酰肽受体样1表达细胞中诱导脱颗粒; 通过激活甲酰肽受体或甲酰肽受体样1刺激细胞外信号调节蛋白激酶磷酸化; 或通过激活甲酰肽受体或甲酰肽受体样1来刺激Akt磷酸化。