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公开(公告)号：US08354400B2
公开(公告)日：2013-01-15
申请号：US13121012
申请日：2009-09-25
申请人： Wanjun Zheng , Mark Spyvee , Fabian Gusovsky , Sally T. Ishizaka
发明人： Wanjun Zheng , Mark Spyvee , Fabian Gusovsky , Sally T. Ishizaka
IPC分类号： A61K31/551 , A61K31/5355 , A61K31/496 , A61K31/4402 , A61K31/4409 , A61K31/443 , A61K31/4453 , A61K31/4468 , A61K31/428
CPC分类号： C07D263/56 , C07D413/12
摘要： The present invention provides benzoxazole compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions including the same. The present invention further provides methods of use as described herein.
摘要翻译： 本发明提供苯并恶唑化合物及其药学上可接受的盐以及包含它们的药物组合物。 本发明进一步提供如本文所述的使用方法。
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公开(公告)号：US07915238B2
公开(公告)日：2011-03-29
申请号：US11411564
申请日：2006-04-26
申请人： Lynn D. Hawkins , Sally T. Ishizaka
发明人： Lynn D. Hawkins , Sally T. Ishizaka
IPC分类号： A61K31/6615 , A61K31/683 , A61K31/14
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/55511
摘要： The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is directed to methods of stimulating and reducing immune responses, therapeutic and prophylactic treatment of cancer, treating autoimmune conditions, treating allergic reactions and asthma, and preventing ischemic damage and asthma by administering one or more immunomodulatory compounds.
摘要翻译： 本发明涉及通过施用一种或多种免疫调节化合物来治疗与免疫应答有关的疾病和病症的方法。 特别地，本发明涉及通过施用一种或多种免疫调节化合物来刺激和减少免疫应答，癌症的治疗和预防性治疗，治疗自身免疫病症，治疗过敏反应和哮喘以及预防缺血性损伤和哮喘的方法。
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公开(公告)号：US06551600B2
公开(公告)日：2003-04-22
申请号：US09918849
申请日：2001-07-31
IPC分类号： A61K4500
CPC分类号： C07F9/10 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/65515
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
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公开(公告)号：US08603482B2
公开(公告)日：2013-12-10
申请号：US13158786
申请日：2011-06-13
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/55511
摘要： The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.
摘要翻译： 本发明涉及免疫治疗化合物以及用于在患有癌症，癌症诊断，癌症治疗或癌症治疗后恢复的危险中的受试个体中刺激免疫应答的方法或本发明的化合物可以是 作为对个体进行预防以预防或延缓癌症的发展。
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公开(公告)号：US20110250171A1
公开(公告)日：2011-10-13
申请号：US13158786
申请日：2011-06-13
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/55511
摘要： The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.
摘要翻译： 本发明涉及免疫治疗化合物以及用于在患有癌症，癌症诊断，癌症治疗或癌症治疗后恢复的危险中的受试个体中刺激免疫应答的方法或本发明的化合物可以是 作为对个体进行预防以预防或延缓癌症的发展。
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6.发明授权公开(公告)号：US06290973B1
公开(公告)日：2001-09-18
申请号：US09496152
申请日：2000-02-01
申请人： Lynn D. Hawkins , Sally T. Ishizaka , Michael Lewis , Pamela McGuiness , Anneliese Nault , Jeffrey Rose , Daniel P. Rossignol
发明人： Lynn D. Hawkins , Sally T. Ishizaka , Michael Lewis , Pamela McGuiness , Anneliese Nault , Jeffrey Rose , Daniel P. Rossignol
IPC分类号： A61K4500
CPC分类号： C07F9/65515 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/10
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
摘要翻译： 本发明涉及当与诸如用于细菌和病毒疾病的疫苗的抗原共同给予包括至少一种本发明的佐剂化合物的新型佐剂制剂与新的免疫刺激组合物共同施用时用作免疫佐剂的新化合物， 包括抗原和至少一种本发明的佐剂化合物，以及通过将本发明化合物与待免疫动物的抗原共同给药的动物免疫方法。
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公开(公告)号：US20110183967A1
公开(公告)日：2011-07-28
申请号：US13121012
申请日：2009-09-25
申请人： Wanjun Zheng , Mark Spyvee , Fabian Gusovsky , Sally T. Ishizaka
发明人： Wanjun Zheng , Mark Spyvee , Fabian Gusovsky , Sally T. Ishizaka
IPC分类号： A61K31/5513 , A61K31/5377 , A61K31/497 , A61K31/444 , A61K31/42 , C07D413/14 , C07D263/56 , A61P37/00 , A61P19/02 , A61P25/00
CPC分类号： C07D263/56 , C07D413/12
摘要： The present invention provides benzoxazole compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions including the same. The present invention further provides methods of use as described herein.
摘要翻译： 本发明提供苯并恶唑化合物及其药学上可接受的盐以及包含它们的药物组合物。 本发明进一步提供如本文所述的使用方法。
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公开(公告)号：US07976852B2
公开(公告)日：2011-07-12
申请号：US11411332
申请日：2006-04-26
IPC分类号： A61K31/395
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/55511
摘要： The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.
摘要翻译： 本发明涉及免疫治疗化合物以及用于在患有癌症，癌症诊断，癌症治疗或癌症治疗后恢复的危险中的受试个体中刺激免疫应答的方法或本发明的化合物可以是 作为对个体进行预防以预防或延缓癌症的发展。
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公开(公告)号：US07833993B2
公开(公告)日：2010-11-16
申请号：US11077344
申请日：2005-03-09
申请人： Lynn D. Hawkins , Sally T. Ishizaka
发明人： Lynn D. Hawkins , Sally T. Ishizaka
IPC分类号： A61K31/6615 , C07F9/10 , C07F9/113
CPC分类号： A61K39/39 , A61K31/16 , A61K31/17 , A61K31/6615 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/10 , C07F9/65515
摘要： The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is directed to methods of stimulating and reducing immune responses, treating autoimmune conditions, treating allergic reactions and asthma, and preventing ischemic damage and asthma by administering one or more immunomodulatory compounds.
摘要翻译： 本发明涉及通过施用一种或多种免疫调节化合物来治疗与免疫应答有关的疾病和病症的方法。 特别地，本发明涉及通过施用一种或多种免疫调节化合物来刺激和减少免疫应答，治疗自身免疫病症，治疗过敏反应和哮喘以及预防缺血性损伤和哮喘的方法。
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公开(公告)号：US06521776B2
公开(公告)日：2003-02-18
申请号：US09919049
申请日：2001-07-30
申请人： Lynn D. Hawkins , Sally T. Ishizaka , Jeffrey Rose , Hu Yang
发明人： Lynn D. Hawkins , Sally T. Ishizaka , Jeffrey Rose , Hu Yang
IPC分类号： C07F909
CPC分类号： C07F9/091 , A61K39/39 , A61K2039/55572 , C07F9/113
摘要： The present invention provides novel compounds that function as immunological adjuvants when co-administered with antigens, including, antigens used as vaccines for any disease or condition amenable to vaccination. The invention also provides adjuvant formulations comprising the novel compounds of the invention and methods for immunizing humans and non-human animals.
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