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公开(公告)号：US20110183967A1
公开(公告)日：2011-07-28
申请号：US13121012
申请日：2009-09-25
申请人： Wanjun Zheng , Mark Spyvee , Fabian Gusovsky , Sally T. Ishizaka
发明人： Wanjun Zheng , Mark Spyvee , Fabian Gusovsky , Sally T. Ishizaka
IPC分类号： A61K31/5513 , A61K31/5377 , A61K31/497 , A61K31/444 , A61K31/42 , C07D413/14 , C07D263/56 , A61P37/00 , A61P19/02 , A61P25/00
CPC分类号： C07D263/56 , C07D413/12
摘要： The present invention provides benzoxazole compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions including the same. The present invention further provides methods of use as described herein.
摘要翻译： 本发明提供苯并恶唑化合物及其药学上可接受的盐以及包含它们的药物组合物。 本发明进一步提供如本文所述的使用方法。
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公开(公告)号：US08354400B2
公开(公告)日：2013-01-15
申请号：US13121012
申请日：2009-09-25
申请人： Wanjun Zheng , Mark Spyvee , Fabian Gusovsky , Sally T. Ishizaka
发明人： Wanjun Zheng , Mark Spyvee , Fabian Gusovsky , Sally T. Ishizaka
IPC分类号： A61K31/551 , A61K31/5355 , A61K31/496 , A61K31/4402 , A61K31/4409 , A61K31/443 , A61K31/4453 , A61K31/4468 , A61K31/428
CPC分类号： C07D263/56 , C07D413/12
摘要： The present invention provides benzoxazole compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions including the same. The present invention further provides methods of use as described herein.
摘要翻译： 本发明提供苯并恶唑化合物及其药学上可接受的盐以及包含它们的药物组合物。 本发明进一步提供如本文所述的使用方法。
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公开(公告)号：US20110105427A1
公开(公告)日：2011-05-05
申请号：US12917669
申请日：2010-11-02
申请人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/496 , A61K31/541 , A61K31/4545 , A61K31/444 , A61K31/4709 , A61K31/55 , A61K31/439 , A61K31/4725 , A61K31/695 , A61P29/00 , A61P35/00 , A61P37/06 , A61P17/06 , A61P11/06 , A61P9/00
CPC分类号： A61K31/437 , C07D471/04
摘要： The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
摘要翻译： 本发明提供了具有式（I）的化合物：其中R 1，R 2，R 3和n如本文中一般和本领域和亚类所述，并且另外提供其药物组合物，及其用于治疗炎症或自身免疫的方法 和增殖性疾病以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。
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公开(公告)号：US07868002B2
公开(公告)日：2011-01-11
申请号：US11906056
申请日：2007-09-28
申请人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号： C07D413/14 , C07D471/02 , A61K31/4745 , A61K31/5377 , A61P11/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P9/00
CPC分类号： A61K31/437 , C07D471/04
摘要： As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.
摘要翻译： 如上所述，仍然需要开发可用于治疗炎性或自身免疫性和增殖性疾病的新型治疗剂。 本发明提供了通式（I）的新型化合物及其药物组合物，如本文中一般和本课程和亚类所述，以及制备和使用这些化合物的方法。
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公开(公告)号：US07314936B2
公开(公告)日：2008-01-01
申请号：US10500840
申请日：2003-01-07
申请人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号： C07D498/02 , C07D513/02 , C07D515/02 , C07D471/02
CPC分类号： A61K31/437 , C07D471/04
摘要： The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally
摘要翻译： 本发明提供具有式（I）的化合物，其中R 1，R 2，R 3和n如通常和类别所述 并且另外提供其药物组合物，及其用于治疗炎性或自身免疫性和增殖性疾病的方法，以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂
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公开(公告)号：US20050124649A1
公开(公告)日：2005-06-09
申请号：US10500840
申请日：2003-01-07
申请人： Jane Daun , Heather Davis , Bruce DeAcosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人： Jane Daun , Heather Davis , Bruce DeAcosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号： A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P1/04 , A61P3/10 , A61P7/04 , A61P9/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D471/04 , C07D519/00 , C07D471/02 , A61K31/4745
CPC分类号： A61K31/437 , C07D471/04
摘要： The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
摘要翻译： 本发明提供具有式（I）的化合物，其中R 1，R 2，R 3和n如通常和类别所述 并且另外提供其药物组合物，以及其用于治疗炎症或自身免疫和增殖性疾病的方法，以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。
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公开(公告)号：US08691814B2
公开(公告)日：2014-04-08
申请号：US12917669
申请日：2010-11-02
申请人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号： A61K31/437 , A61K31/496 , A61K31/4545 , A61K31/444 , A61P35/00
CPC分类号： A61K31/437 , C07D471/04
摘要： The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
摘要翻译： 本发明提供了具有式（I）的化合物：其中R 1，R 2，R 3和n如本文中一般和本领域和亚类所述，并且另外提供其药物组合物，及其用于治疗炎症或自身免疫的方法 和增殖性疾病以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。
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公开(公告)号：US20080103137A1
公开(公告)日：2008-05-01
申请号：US11906056
申请日：2007-09-28
申请人： Jane Daun , Heather Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人： Jane Daun , Heather Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号： A61K31/4745 , A61K31/5377 , A61P11/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P35/00 , A61P9/00 , C07D413/14 , C07D471/02
CPC分类号： A61K31/437 , C07D471/04
摘要： As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds
摘要翻译： 如上所述，仍然需要开发可用于治疗炎性或自身免疫性和增殖性疾病的新型治疗剂。 本发明提供通式（I）的新化合物及其药物组合物，如本文中一般和本课题和亚类所述，以及制备和使用这些化合物的方法
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公开(公告)号：US06214865B1
公开(公告)日：2001-04-10
申请号：US09334488
申请日：1999-06-16
申请人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
发明人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
IPC分类号： A61K31335
CPC分类号： C07D493/22
摘要： The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained mitotic block in a cell after transient exposure of the cell to the agents.
摘要翻译： 本发明提供了具有药学活性的软骨素类似物，例如抗癌或抗有丝分裂（有丝分裂阻断）活性，以及鉴定在细胞瞬时暴露于药剂后在细胞中诱导持续有丝分裂阻滞的药剂的方法。
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公开(公告)号：US08097648B2
公开(公告)日：2012-01-17
申请号：US11282505
申请日：2005-11-18
IPC分类号： A61K31/335
CPC分类号： A61K31/4745 , A61K31/335 , A61K31/35 , A61K31/7072 , A61K39/39558 , A61K45/06 , C07D493/22 , A61K2300/00
摘要： The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer.
摘要翻译： 本发明提供了用于治疗与过度细胞增殖相关的疾病如癌症的方法和组合物。
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