公开(公告)号：US06489512B1

公开(公告)日：2002-12-03

申请号：US10177381

申请日：2002-06-21

申请人： Frederick Hicks ,  Da-Ming Gou ,  Salvatore Anthony Marchese ,  Lawrence J. Martel ,  Atena Necula ,  Richard E. Benetti ,  Richard A. Silva

发明人： Frederick Hicks ,  Da-Ming Gou ,  Salvatore Anthony Marchese ,  Lawrence J. Martel ,  Atena Necula ,  Richard E. Benetti ,  Richard A. Silva

IPC分类号： C07C25100

CPC分类号： C07D211/70 ,  C07D401/04

摘要： A method for making an indole compound includes transition metal-catalyzed arylation of a hydrazone to form an aryl hydrazone, hydrolysis of the aryl hydrazone to form an aryl hydrazine, and acid catalyzed cyclization of the aryl hydrazine to form the indole compound.

摘要翻译： 制备吲哚化合物的方法包括腙的过渡金属催化芳基化以形成芳基腙，芳基腙水解形成芳基肼，以及芳基肼酸催化环化形成吲哚化合物。

公开(公告)号：US06693206B2

公开(公告)日：2004-02-17

申请号：US10225869

申请日：2002-08-22

申请人： Yi Liu ,  Marcello DiMare ,  Salvatore Anthony Marchese ,  Eric N. Jacobsen ,  Serge Jasmin

发明人： Yi Liu ,  Marcello DiMare ,  Salvatore Anthony Marchese ,  Eric N. Jacobsen ,  Serge Jasmin

IPC分类号： C07D30132

CPC分类号： C07D303/48 ,  C07B2200/07 ,  C07C27/00 ,  C07C29/106 ,  C07C2523/75 ,  C07D301/32 ,  C07D303/04 ,  C07D303/08 ,  C07C33/26 ,  C07C31/205 ,  C07C31/42

摘要： The present invention provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. The process includes the step of contacting oxygen and mixture including a racemic chiral epoxy compound, a non-racemic Co(II) complex catalyst, an aromatic carboxylic acid and water, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound. The present invention also provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. This process includes the step of: contacting a racemic chiral epoxy compound and water in the presence of a non-racemic complex of Co(III) having an aryl carboxylate counter-anion, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound.

摘要翻译： 本发明提供了通过水解动力学拆分反应制备对映体富集的非外消旋手性二醇和对映体富集的非外消旋手性环氧化合物的方法。 该方法包括使氧气和包含外消旋手性环氧化合物，非外消旋Co（II）配合物催化剂，芳族羧酸和水）的混合物的温度和时间长度足以产生所述非 - - 外消旋手性二醇和所述非外消旋手性环氧化合物。 本发明还提供了通过水解动力学拆分反应制备对映体富集的非外消旋手性二醇和对映体富集的非外消旋手性环氧化合物的方法。 该方法包括以下步骤：在具有芳基羧酸酯阴离子的Co（III）的非外消旋配合物的存在下，在足以产生以下物质的混合物的温度和时间长度下，使外消旋手性环氧化合物和水接触 所述非外消旋手性二醇和所述非外消旋手性环氧化合物。