公开(公告)号：US06395913B1

公开(公告)日：2002-05-28

申请号：US09910359

申请日：2001-07-20

申请人： Scott Donald Barnicki ,  Jerome Leonard Stavinoha, Jr. ,  Robert Sterling Kline ,  Jackie Lee Hamilton

发明人： Scott Donald Barnicki ,  Jerome Leonard Stavinoha, Jr. ,  Robert Sterling Kline ,  Jackie Lee Hamilton

IPC分类号： C07D30132

CPC分类号： C07D301/32 ,  C07D301/10

摘要： Disclosed is a method of recovering and purifying 3,4-epoxy-1-butene (epoxybutene) from a reaction product gas, obtained by the vapor phase catalytic partial oxidation of 1,3-butadiene with oxygen over a silver catalyst. The recovery and purification comprises absorption of the epoxybutene into a water-miscible solvent followed by separation of the absorbed epoxybutene from the absorbent by extraction into a water-immiscible solvent. A method of recovering and purifying epoxybutene from the extraction solvent and other reaction by-products by a novel combination of distillation and decantation steps also is disclosed.

摘要翻译： 公开了一种通过在银催化剂上用氧气气相催化部分氧化1,3-丁二烯而获得的反应产物气体中3,4-环氧-1-丁烯（环氧丁烯）的回收和纯化方法。 回收和纯化包括将环氧丁烯吸收到水混溶性溶剂中，然后通过萃取与水不混溶的溶剂将吸收的环氧丁烯从吸收剂中分离出来。 公开了一种通过蒸馏和倾析步骤的新组合从提取溶剂和其它反应副产物中回收和纯化环氧丁烯的方法。

公开(公告)号：US06693206B2

公开(公告)日：2004-02-17

申请号：US10225869

申请日：2002-08-22

申请人： Yi Liu ,  Marcello DiMare ,  Salvatore Anthony Marchese ,  Eric N. Jacobsen ,  Serge Jasmin

发明人： Yi Liu ,  Marcello DiMare ,  Salvatore Anthony Marchese ,  Eric N. Jacobsen ,  Serge Jasmin

IPC分类号： C07D30132

CPC分类号： C07D303/48 ,  C07B2200/07 ,  C07C27/00 ,  C07C29/106 ,  C07C2523/75 ,  C07D301/32 ,  C07D303/04 ,  C07D303/08 ,  C07C33/26 ,  C07C31/205 ,  C07C31/42

摘要： The present invention provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. The process includes the step of contacting oxygen and mixture including a racemic chiral epoxy compound, a non-racemic Co(II) complex catalyst, an aromatic carboxylic acid and water, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound. The present invention also provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. This process includes the step of: contacting a racemic chiral epoxy compound and water in the presence of a non-racemic complex of Co(III) having an aryl carboxylate counter-anion, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound.

摘要翻译： 本发明提供了通过水解动力学拆分反应制备对映体富集的非外消旋手性二醇和对映体富集的非外消旋手性环氧化合物的方法。 该方法包括使氧气和包含外消旋手性环氧化合物，非外消旋Co（II）配合物催化剂，芳族羧酸和水）的混合物的温度和时间长度足以产生所述非 - - 外消旋手性二醇和所述非外消旋手性环氧化合物。 本发明还提供了通过水解动力学拆分反应制备对映体富集的非外消旋手性二醇和对映体富集的非外消旋手性环氧化合物的方法。 该方法包括以下步骤：在具有芳基羧酸酯阴离子的Co（III）的非外消旋配合物的存在下，在足以产生以下物质的混合物的温度和时间长度下，使外消旋手性环氧化合物和水接触 所述非外消旋手性二醇和所述非外消旋手性环氧化合物。

公开(公告)号：US06346632B1

公开(公告)日：2002-02-12

申请号：US08487584

申请日：1995-06-07

申请人： Luca Ghirotto ,  Stefano Servi ,  Claudio Fuganti ,  Angelo Gentile ,  Claudio Giordano

发明人： Luca Ghirotto ,  Stefano Servi ,  Claudio Fuganti ,  Angelo Gentile ,  Claudio Giordano

IPC分类号： C07D30132

CPC分类号： C07D407/12 ,  C07D281/10 ,  C07D303/48 ,  C12P17/02 ,  C12P41/005

摘要： A process for the preparation of the compounds of formula (wherein R has the meanings reported in the specification) by enzymatic transesterification of enantiomeric mixtures is described. These compounds are intermediates useful in the synthesis of Diltiazem.

摘要翻译： 描述了通过对映异构体混合物的酶促酯交换反应制备式（其中R具有说明书中报道的含义）的方法。这些化合物是可用于合成地尔硫卓的中间体。

公开(公告)号：US06624319B2

公开(公告)日：2003-09-23

申请号：US10203185

申请日：2002-10-04

申请人： Willi Hofen ,  Georg Thiele

发明人： Willi Hofen ,  Georg Thiele

IPC分类号： C07D30132

CPC分类号： C07D301/32 ,  C07D301/12

摘要： The present invention relates to a process for the catalytic epoxidation of olefins in which in one reaction stage the olefin is reacted with aqueous hydrogen peroxide in an organic, water-miscible solvent in the presence of a titanium silicalite catalyst, wherein an exit gas stream is obtained which contains olefin oxide, unreacted olefin and oxygen and this exit gas stream is brought into contact in an absorption unit with the same solvent as used in the reaction stage and a solvent stream loaded with olefin and olefin oxide is drawn off from the absorption unit and an exit gas stream containing oxygen is discharged.

摘要翻译： 本发明涉及烯烃的催化环氧化方法，其中在一个反应​​阶段中，在钛硅沸石催化剂存在下，烯烃与有机水溶性溶剂中的过氧化氢水溶液反应，其中出口气流为 得到的，其含有烯烃氧化物，未反应的烯烃和氧气，并且该出口气体流在与反应阶段中使用的溶剂相同的吸收单元中接触，并且从吸收单元中排出负载有烯烃和烯烃氧化物的溶剂流 排出含有氧的出口气体流。

公开(公告)号：US06500970B1

公开(公告)日：2002-12-31

申请号：US09910330

申请日：2001-07-20

申请人： Scott Donald Barnicki ,  Jerome Leonard Stavinoha, Jr. ,  Robert Sterling Kline ,  Jackie Lee Hamilton

发明人： Scott Donald Barnicki ,  Jerome Leonard Stavinoha, Jr. ,  Robert Sterling Kline ,  Jackie Lee Hamilton

IPC分类号： C07D30132

CPC分类号： C07D301/32

摘要： Disclosed is a process of recovering 3,4-epoxy-1-butene (epoxybutene) from an epoxybutene-laden reaction product gas by absorption into a high-boiling solvent. Also disclosed is a process for the purification of the epoxybutene by separating epoxybutene from the solvent and other reaction by-products by a novel combination of distillation and decantation steps.

摘要翻译： 公开了通过吸收到高沸点溶剂中从含环氧丁烯的反应产物气中回收3,4-环氧-1-丁烯（环氧丁烯）的方法。 还公开了通过蒸馏和倾析步骤的新组合从溶剂和其它反应副产物中分离环氧丁烯来纯化环氧丁烯的方法。

公开(公告)号：US06462209B1

公开(公告)日：2002-10-08

申请号：US09936650

申请日：2001-09-14

申请人： Johannes Gerhardus Joseph Beckers ,  Johannes Jozias Blom

发明人： Johannes Gerhardus Joseph Beckers ,  Johannes Jozias Blom

IPC分类号： C07D30132

CPC分类号： C07D301/32

摘要： Process for improving the quality of a propylene oxide contaminated with poly(propylene oxide), which process comprises the steps of: (a) contacting the liquid propylene oxide with an adsorbent consisting of magnesium silicate and/or calcium silicate under such conditions that the amount of poly(propylene oxide) is reduced to the desired level, and (b) recovering the purified propylene oxide product.

摘要翻译： 用于改善被聚（环氧丙烷）污染的环氧丙烷的质量的方法，该方法包括以下步骤：（a）使液体环氧丙烷与由硅酸镁和/或硅酸钙组成的吸附剂接触， 的聚（环氧丙烷）降低到所需的水平，和（b）回收纯化的环氧丙烷产物。

公开(公告)号：US06677468B1

公开(公告)日：2004-01-13

申请号：US09912453

申请日：2001-07-24

申请人： Mark T. Dimke ,  Richard E. Miller

发明人： Mark T. Dimke ,  Richard E. Miller

IPC分类号： C07D30132

CPC分类号： C07D301/32

摘要： In accordance with the present invention, methods have been developed for the reduction of the chloride content of epoxy compound starting materials. Invention methods comprise fractionating an epoxy compound starting material into portions (e.g., fractions or cuts) having different chloride content relative to the epoxy compound starting material. Certain of these collected portions (i.e., the portions fractionated and collected after collection of the forecut and before discontinuation of the fractionation) contain substantially reduced chloride levels relative to the epoxy compound starting material.

摘要翻译： 根据本发明，已经开发了用于降低环氧化合物起始材料的氯化物含量的方法。 本发明的方法包括将环氧化合物原料分馏成相对于环氧化合物起始原料具有不同氯化物含量的部分（例如，馏分或切割）。 这些收集的部分中的某些（即，在收集前述之后和分离之前分离和收集的部分）相对于环氧化合物起始材料含有显着降低的氯化物含量。

公开(公告)号：US06596882B2

公开(公告)日：2003-07-22

申请号：US09910332

申请日：2001-07-20

申请人： Scott Donald Barnicki ,  Jerome Leonard Stavinoha, Jr. ,  Robert Sterling Kline ,  Steven Edward Briley ,  Jackie Lee Hamilton

发明人： Scott Donald Barnicki ,  Jerome Leonard Stavinoha, Jr. ,  Robert Sterling Kline ,  Steven Edward Briley ,  Jackie Lee Hamilton

IPC分类号： C07D30132

CPC分类号： C07D301/32

摘要： Disclosed is a method of recovering and purifying 3,4-epoxy-1-butene (epoxybutene) from an epoxidation effluent gas obtained by the vapor phase, catalytic, partial oxidation of 1,3-butadiene (butadiene) with molecular oxygen in the presence of a silver catalyst wherein the epoxybutene-laden epoxidation product gas is reacted with a water-miscible solvent to absorb the epoxybutene. The disclosed process includes a method of separating epoxybutene from the solvent and other reaction by-products by a novel combination of distillation and decantation steps.

公开(公告)号：US06211389B1

公开(公告)日：2001-04-03

申请号：US09578785

申请日：2000-05-23

申请人： Mark Thomas Dimke

发明人： Mark Thomas Dimke

IPC分类号： C07D30132

CPC分类号： C07D301/32 ,  C08G59/025

摘要： In accordance with the present invention, methods have been developed for the reduction of the chloride content of epoxy compound starting materials. Invention methods comprise subjecting specifically defined combinations comprising an epoxy resin starting material and other components to conditions sufficient to produce a treated epoxy compound (i.e., an epoxy compound having a chloride content which is reduced relative to that of the epoxy resin starting material), and separating the treated epoxy compound from the combination. Other components contemplated for use in the practice of the present invention comprise, alternatively, mixtures of crown ether, organic solvent and suitable base; mixtures of crown ether-like solvent and suitable base; mixtures of aprotic solvents and hydrides (other than tin hydride); mixtures of nonhalogenated organic solvent and reducing metal; and the like. In accordance with a further aspect of the present invention, products (i.e., treated epoxy compounds, encapsulants and fillers) are provided which have been produced by the invention methods.

摘要翻译： 根据本发明，已经开发了用于降低环氧化合物起始材料的氯化物含量的方法。 本发明的方法包括将包含环氧树脂起始材料和其它组分的具体限定的组合经受足以产生经处理的环氧化合物（即相对于环氧树脂原料的氯化物含量降低的环氧化合物）的条件，以及 将处理的环氧化合物与组合物分离。 考虑用于本发明实践的其它组分包括冠醚，有机溶剂和合适碱的混合物; 冠醚类溶剂和合适碱的混合物; 非质子溶剂和氢化物（除氢化锡之外）的混合物; 非卤代有机溶剂和还原金属的混合物; 等等。 根据本发明的另一方面，提供了通过本发明方法生产的产品（即经处理的环氧化合物，密封剂和填料）。

公开(公告)号：US06639087B2

公开(公告)日：2003-10-28

申请号：US10225902

申请日：2002-08-22

申请人： Jay F. Larrow ,  Serge Jasmin ,  Yi Liu ,  Marcello Di Mare

发明人： Jay F. Larrow ,  Serge Jasmin ,  Yi Liu ,  Marcello Di Mare

IPC分类号： C07D30132

CPC分类号： C07D301/32 ,  C07B2200/07 ,  C07C27/00 ,  C07C29/106 ,  C07C2523/75 ,  C07D303/04 ,  C07D303/08 ,  C07D303/48 ,  Y02P20/584 ,  C07C31/36 ,  C07C31/42 ,  C07C33/26

摘要： A method for stereoselective chemical synthesis, includes the steps of: (A) reacting a nucleophile and chiral or prochiral cyclic subtrate, said substrate comprising a carbocycle or a heterocycle having a reactive center susceptible to nucleophilic attack by the nucleophile, in the presence of a chiral non-racemic catalyst to produce a product mixture comprising a stereomerically enriched product wherein the product mixture further comprises a catalyst residue, at least a portion of the catalyst residue is in a first oxidation state, and the catalyst residue in the first oxidation state is active in catalyzing degradation of the stereoisomerically enriched product, and (B) chemically or electochemically changing the oxidation state of the catalyst residue from the first oxidation state to a second oxidation state, wherein catalyst residue in the second oxidation state is less active in catalyzing degradation of the stereoisomerically enriched product than is catalyst residue in the first oxidation state. The method reduces erosion of the chiral purity of the stereoisomerically enriched product and reduces the chemical transformation to side products of the stereoisomerically enriched product and co-product(s). The deactivated catalyst is recoverable and recyclable.

摘要翻译： 一种用于立体选择性化学合成的方法包括以下步骤：（A）使亲核试剂和手性或前手性环状残留物反应，所述底物包含具有易受亲核试剂亲核攻击的反应性中心的碳环或杂环， 手性非外消旋催化剂以产生包含立体富集产物的产物混合物，其中产物混合物还包含催化剂残余物，至少一部分催化剂残余物处于第一氧化态，第一氧化态的催化剂残余物为 有效催化立体异构体富集产物的降解，和（B）将催化剂残余物从第一氧化态的氧化态化学或电化学地改变为第二氧化态，其中在第二氧化态的催化剂残余物在催化降解中的活性较低 的立体异构体富集产物比冷杉中的催化剂残余物 st氧化态。 该方法减少了立体异构体富集产物的手性纯度的侵蚀，并减少了立体异构富集的产物和副产物的副产物的化学转化。 失活的催化剂是可回收和可回收的。