公开(公告)号：US10665323B2

公开(公告)日：2020-05-26

申请号：US15313493

申请日：2015-05-28

申请人： Roland Grafstrom ,  Pekka Kohonen ,  Juuso Parkkinen ,  Samuel Kaski

发明人： Roland Grafstrom ,  Pekka Kohonen ,  Juuso Parkkinen ,  Samuel Kaski

IPC分类号： G16B5/00 ,  G16B25/00 ,  G16C20/30 ,  C12Q1/6876 ,  G16B20/00 ,  G16C20/10 ,  G16C20/70

摘要： A novel method to predict toxicity and dose-dependent effects of an agent based on transcriptomic data analysis, by determining a predictive toxicogenomics space (PTGS) score. The PTGS score helps to predict and model the toxicity of compounds typically consisting of chemicals, pharmaceuticals, cosmetics and agrochemicals. The invention further comprises methods of deriving the PTGS score, as well as computer programs to calculate PTGS scores.

公开(公告)号：US20170270239A1

公开(公告)日：2017-09-21

申请号：US15313493

申请日：2015-05-28

申请人： Roland Grafstrom ,  Pekka Kohonen ,  Juuso Parkkinen ,  Samuel Kaski

发明人： Roland Grafstrom ,  Pekka Kohonen ,  Juuso Parkkinen ,  Samuel Kaski

IPC分类号： G06F19/12 ,  G06F19/20 ,  C12Q1/68

CPC分类号： G16B5/00 ,  C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158 ,  G16B20/00 ,  G16B25/00 ,  G16C20/10 ,  G16C20/30 ,  G16C20/70

摘要： A novel method to predict toxicity and dose-dependent effects of an agent based on transcriptomic data analysis, by determining a predictive toxicogenomics space (PTGS) score. The PTGS score helps to predict and model the toxicity of compounds typically consisting of chemicals, pharmaceuticals, cosmetics and agrochemicals. The invention further comprises methods of deriving the PTGS score, as well as computer programs to calculate PTGS scores.