公开(公告)号：US20100310465A1

公开(公告)日：2010-12-09

申请号：US12841331

申请日：2010-07-22

申请人： Jeffrey I. Zink ,  Jie Lu ,  Fuyuhiko Tamanoi ,  Andre Nel ,  Sarah Angelos ,  Fraser Stoddart ,  Qiaolin Chen ,  Tian Xia ,  Kaushik Patel ,  William Dichtel

发明人： Jeffrey I. Zink ,  Jie Lu ,  Fuyuhiko Tamanoi ,  Andre Nel ,  Sarah Angelos ,  Fraser Stoddart ,  Qiaolin Chen ,  Tian Xia ,  Kaushik Patel ,  William Dichtel

IPC分类号： A61K9/14 ,  A61K31/352 ,  A61P27/02 ,  A61P39/06 ,  A61P29/00 ,  A61P37/06 ,  A61P35/00 ,  A61P25/08 ,  A61P31/12 ,  A61P9/12 ,  A61P7/02 ,  B01J19/00 ,  A61K49/00

CPC分类号： A61K9/5115 ,  A61K31/352 ,  A61K47/60 ,  A61K47/6923 ,  A61K47/6949 ,  B82Y5/00 ,  B82Y30/00

摘要： A nanodevice has a containment vessel defining a storage chamber therein and defining at least one port to provide access to and from said storage chamber, and a stopper assembly attached to the containment vessel. The stopper assembly has a blocking unit arranged proximate the at least one port and has a structure suitable to substantially prevent material after being loaded into the storage chamber from being released while the blocking unit is arranged in a blocking configuration. The stopper assembly is responsive to the presence of a predetermined stimulus such that the blocking unit is released in the presence of the predetermined stimulus to allow the material to be released from the storage chamber. The predetermined stimulus is a predetermined catalytic activity that is suitable to at least one of cleave, hydrolyze, oxidize, or reduce a portion of the stopper assembly, and the nanodevice has a maximum dimension of about 1 μm.

摘要翻译： 纳米装置具有容纳容器，在其中限定储存室并且限定至少一个端口以提供与所述储存室的通路，以及附接到所述容纳容器的止动器组件。 止动器组件具有靠近所述至少一个端口布置的阻挡单元，并且具有适于基本上防止材料在被装载到储存室中之后被释放的结构，同时阻挡单元被布置成阻挡构造。 止动器组件响应于预定刺激的存在，使得阻挡单元在预定刺激的存在下被释放以允许材料从储存室释放。 预定的刺激是适合于切割，水解，氧化或减少塞子组件的一部分中的至少一种的预定催化活性，并且纳米装置具有约1μm的最大尺寸。

公开(公告)号：US20100284924A1

公开(公告)日：2010-11-11

申请号：US12812359

申请日：2009-01-23

申请人： Jeffrey I. Zink ,  Fuyuhiko Tamanoi ,  Eunshil Choi ,  Sarah Angelos ,  Sanaz Kabehie ,  Andre Nel ,  Jie Lu

发明人： Jeffrey I. Zink ,  Fuyuhiko Tamanoi ,  Eunshil Choi ,  Sarah Angelos ,  Sanaz Kabehie ,  Andre Nel ,  Jie Lu

IPC分类号： A61K9/14 ,  B32B5/00 ,  A61K8/02 ,  A61K49/00 ,  A61P43/00 ,  A61P35/00 ,  A61Q90/00

CPC分类号： A61K9/0097 ,  A61K9/5115 ,  A61K9/5192 ,  A61N5/062 ,  B01L3/50273 ,  B82Y15/00 ,  F04B19/006 ,  F04D29/026 ,  F04D33/00 ,  Y10T428/2982

摘要： A nanodevice has a containment vessel defining a storage chamber therein and defining at least one port to provide transfer of molecules to or from the storage chamber, and a plurality of impellers attached to the containment vessel. The plurality of impellers are of a structure and are arranged to substantially block molecules from entering and exiting the storage chamber of the containment vessel when the impellers are static and are operable to impart motion to the molecules to cause the molecules to at least one of enter into or exit from the storage chamber of the containment vessel.

摘要翻译： 纳米装置具有容纳容器，在其中限定存储室并且限定至少一个端口以提供分配到储存室或从存储室传送分子，以及附接到容纳容器的多个叶轮。 多个叶轮具有结构并且被布置成当叶轮静止时基本上阻挡分子进入和离开容纳容器的储存室，并且可操作地使分子运动到使分子进入至少一个进入 进入或离开安全壳的储存室。

公开(公告)号：US20130046274A1

公开(公告)日：2013-02-21

申请号：US13550374

申请日：2012-07-16

申请人： Jeffrey I. Zink ,  Courtney R. Thomas ,  Monty Liong ,  Sarah Angelos Henscheid ,  Jinwoo Cheon ,  Jae-Hyun Lee ,  Daniel P. Ferris

发明人： Jeffrey I. Zink ,  Courtney R. Thomas ,  Monty Liong ,  Sarah Angelos Henscheid ,  Jinwoo Cheon ,  Jae-Hyun Lee ,  Daniel P. Ferris

IPC分类号： A61M5/168 ,  B82Y5/00

CPC分类号： A61K9/5094 ,  A61K41/0028 ,  A61M2205/0288 ,  A61M2205/368

摘要： A method for controlled delivery of a substance into a body includes administering a plurality of containment vessels into the body, in which each of the plurality of containment vessels includes a quantity of the substance loaded therein prior to the administering; and providing a time-varying magnetic field such that the plurality of containment vessels are exposed thereto to cause a release of at least a portion of the substance from the plurality of containment vessels. Each of the plurality of containment vessels has an average outer diameter less than about 1 μm.

摘要翻译： 将物质控制递送到体内的方法包括将多个容纳容器施用到体内，其中多个容纳容器中的每个容纳容器在施用之前包括一定量的其中装载的物质; 以及提供随时间变化的磁场，使得所述多个容纳容器暴露于其中以引起所述物质的至少一部分从所述多个容纳容器释放。 多个容纳容器中的每一个具有小于约1μm的平均外径。