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1.发明申请NANO-DEVICES HAVING RELEASABLE SEALS FOR CONTROLLED RELEASE OF MOLECULES 审中-公开具有用于控制释放分子的可释放密封件的纳米器件公开(公告)号：US20100310465A1
公开(公告)日：2010-12-09
申请号：US12841331
申请日：2010-07-22
申请人： Jeffrey I. Zink , Jie Lu , Fuyuhiko Tamanoi , Andre Nel , Sarah Angelos , Fraser Stoddart , Qiaolin Chen , Tian Xia , Kaushik Patel , William Dichtel
发明人： Jeffrey I. Zink , Jie Lu , Fuyuhiko Tamanoi , Andre Nel , Sarah Angelos , Fraser Stoddart , Qiaolin Chen , Tian Xia , Kaushik Patel , William Dichtel
IPC分类号： A61K9/14 , A61K31/352 , A61P27/02 , A61P39/06 , A61P29/00 , A61P37/06 , A61P35/00 , A61P25/08 , A61P31/12 , A61P9/12 , A61P7/02 , B01J19/00 , A61K49/00
CPC分类号： A61K9/5115 , A61K31/352 , A61K47/60 , A61K47/6923 , A61K47/6949 , B82Y5/00 , B82Y30/00
摘要： A nanodevice has a containment vessel defining a storage chamber therein and defining at least one port to provide access to and from said storage chamber, and a stopper assembly attached to the containment vessel. The stopper assembly has a blocking unit arranged proximate the at least one port and has a structure suitable to substantially prevent material after being loaded into the storage chamber from being released while the blocking unit is arranged in a blocking configuration. The stopper assembly is responsive to the presence of a predetermined stimulus such that the blocking unit is released in the presence of the predetermined stimulus to allow the material to be released from the storage chamber. The predetermined stimulus is a predetermined catalytic activity that is suitable to at least one of cleave, hydrolyze, oxidize, or reduce a portion of the stopper assembly, and the nanodevice has a maximum dimension of about 1 μm.
摘要翻译： 纳米装置具有容纳容器，在其中限定储存室并且限定至少一个端口以提供与所述储存室的通路，以及附接到所述容纳容器的止动器组件。 止动器组件具有靠近所述至少一个端口布置的阻挡单元，并且具有适于基本上防止材料在被装载到储存室中之后被释放的结构，同时阻挡单元被布置成阻挡构造。 止动器组件响应于预定刺激的存在，使得阻挡单元在预定刺激的存在下被释放以允许材料从储存室释放。 预定的刺激是适合于切割，水解，氧化或减少塞子组件的一部分中的至少一种的预定催化活性，并且纳米装置具有约1μm的最大尺寸。
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2.发明申请公开(公告)号：US20100284924A1
公开(公告)日：2010-11-11
申请号：US12812359
申请日：2009-01-23
申请人： Jeffrey I. Zink , Fuyuhiko Tamanoi , Eunshil Choi , Sarah Angelos , Sanaz Kabehie , Andre Nel , Jie Lu
发明人： Jeffrey I. Zink , Fuyuhiko Tamanoi , Eunshil Choi , Sarah Angelos , Sanaz Kabehie , Andre Nel , Jie Lu
CPC分类号： A61K9/0097 , A61K9/5115 , A61K9/5192 , A61N5/062 , B01L3/50273 , B82Y15/00 , F04B19/006 , F04D29/026 , F04D33/00 , Y10T428/2982
摘要： A nanodevice has a containment vessel defining a storage chamber therein and defining at least one port to provide transfer of molecules to or from the storage chamber, and a plurality of impellers attached to the containment vessel. The plurality of impellers are of a structure and are arranged to substantially block molecules from entering and exiting the storage chamber of the containment vessel when the impellers are static and are operable to impart motion to the molecules to cause the molecules to at least one of enter into or exit from the storage chamber of the containment vessel.
摘要翻译： 纳米装置具有容纳容器，在其中限定存储室并且限定至少一个端口以提供分配到储存室或从存储室传送分子，以及附接到容纳容器的多个叶轮。 多个叶轮具有结构并且被布置成当叶轮静止时基本上阻挡分子进入和离开容纳容器的储存室，并且可操作地使分子运动到使分子进入至少一个进入 进入或离开安全壳的储存室。
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公开(公告)号：US09993437B2
公开(公告)日：2018-06-12
申请号：US12746375
申请日：2008-12-08
申请人： Monty Liong , Jie Lu , Fuyuhiko Tamanoi , Jeffrey I. Zink , Andre Nel
发明人： Monty Liong , Jie Lu , Fuyuhiko Tamanoi , Jeffrey I. Zink , Andre Nel
IPC分类号： A61K9/14 , A61K9/51 , A61K9/50 , A61K31/337 , A61K31/4375 , A61K49/00 , A61K49/18 , B82Y5/00
CPC分类号： A61K9/5115 , A61K9/5094 , A61K31/337 , A61K31/4375 , A61K49/0002 , A61K49/0043 , A61K49/0052 , A61K49/0093 , A61K49/183 , B82Y5/00
摘要： A submicron structure includes a silica body defining a plurality of pores that are suitable to receive molecules therein, the silica body further defining an outer surface between pore openings of the plurality of pores; and a plurality of anionic molecules attached to the outer surface of the silica body. The anionic molecules provide hydrophilicity to the submicron structure and are suitable to provide repulsion between other similar submicron structures, and the submicron structure has a maximum dimension less than one micron.
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公开(公告)号：US20100255103A1
公开(公告)日：2010-10-07
申请号：US12746375
申请日：2008-12-08
申请人： Monty Liong , Jie Lu , Fuyuhiko Tamanoi , Jeffrey I. Zink , Andre Nel
发明人： Monty Liong , Jie Lu , Fuyuhiko Tamanoi , Jeffrey I. Zink , Andre Nel
IPC分类号： A61K9/14 , A61K31/4375 , A61K31/337 , A61K31/05 , A61K31/7048 , A61K31/17 , A61P35/00
CPC分类号： A61K9/5115 , A61K9/5094 , A61K31/337 , A61K31/4375 , A61K49/0002 , A61K49/0043 , A61K49/0052 , A61K49/0093 , A61K49/183 , B82Y5/00
摘要： A submicron structure includes a silica body defining a plurality of pores that are suitable to receive molecules therein, the silica body further defining an outer surface between pore openings of said plurality of pores; and a plurality of anionic molecules attached to the outer surface of the silica body. The anionic molecules provide hydrophilicity to the submicron structure and are suitable to provide repulsion between other similar submicron structures, and the submicron structure has a maximum dimension less than one micron.
摘要翻译： 亚微米结构包括限定适合于在其中接收分子的多个孔的二氧化硅主体，所述二氧化硅本体还限定所述多个孔的孔口之间的外表面; 以及附着在二氧化硅体的外表面上的多个阴离子分子。 阴离子分子为亚微米结构提供亲水性，适用于在其他类似的亚微米结构之间提供排斥性，而亚微米结构的最大尺寸小于1微米。
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公开(公告)号：US20130046274A1
公开(公告)日：2013-02-21
申请号：US13550374
申请日：2012-07-16
申请人： Jeffrey I. Zink , Courtney R. Thomas , Monty Liong , Sarah Angelos Henscheid , Jinwoo Cheon , Jae-Hyun Lee , Daniel P. Ferris
发明人： Jeffrey I. Zink , Courtney R. Thomas , Monty Liong , Sarah Angelos Henscheid , Jinwoo Cheon , Jae-Hyun Lee , Daniel P. Ferris
CPC分类号： A61K9/5094 , A61K41/0028 , A61M2205/0288 , A61M2205/368
摘要： A method for controlled delivery of a substance into a body includes administering a plurality of containment vessels into the body, in which each of the plurality of containment vessels includes a quantity of the substance loaded therein prior to the administering; and providing a time-varying magnetic field such that the plurality of containment vessels are exposed thereto to cause a release of at least a portion of the substance from the plurality of containment vessels. Each of the plurality of containment vessels has an average outer diameter less than about 1 μm.
摘要翻译： 将物质控制递送到体内的方法包括将多个容纳容器施用到体内，其中多个容纳容器中的每个容纳容器在施用之前包括一定量的其中装载的物质; 以及提供随时间变化的磁场，使得所述多个容纳容器暴露于其中以引起所述物质的至少一部分从所述多个容纳容器释放。 多个容纳容器中的每一个具有小于约1μm的平均外径。
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6.发明申请CATIONIC POLYMER COATED MESOPOROUS SILICA NANOPARTICLES AND USES THEREOF 审中-公开阳离子聚合物包覆的多孔二氧化硅纳米颗粒及其用途公开(公告)号：US20120207795A1
公开(公告)日：2012-08-16
申请号：US13428830
申请日：2012-03-23
申请人： Jeffrey I. Zink , Andre E. Nel , Tian Xia , Zhaoxia Ji , Huan Meng , Zongxi Li , Monty Liong , Min Xue , Derrick Y. Tarn
发明人： Jeffrey I. Zink , Andre E. Nel , Tian Xia , Zhaoxia Ji , Huan Meng , Zongxi Li , Monty Liong , Min Xue , Derrick Y. Tarn
CPC分类号： B82Y5/00 , A61K9/0019 , A61K9/5115 , A61K9/5146 , A61K9/5192 , A61K31/704 , A61K31/713 , Y10T428/2982 , A61K2300/00
摘要： A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
摘要翻译： 描述了具有限定多个孔的二氧化硅主体的亚微米结构。 亚微米体可以是球形或非球形的，并且可以在所述二氧化硅体的表面上包括阳离子聚合物或共聚物。 亚微米结构可以进一步包括寡核苷酸并用于将寡核苷酸递送至细胞。 亚微米结构可进一步包括治疗剂并用于将治疗剂递送至细胞。 寡核苷酸和治疗剂可以一起使用。 例如，当寡核苷酸是siRNA时，组合物可以通过降低抗性基因的翻译来降低对治疗剂的细胞抗性。
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7.发明申请STRUCTURED SILVER-MESOPOROUS SILICA NANOPARTICLES HAVING ANTIMICROBIAL ACTIVITY 审中-公开具有抗微生物活性的结构银 - 多孔二氧化硅纳米颗粒公开(公告)号：US20120021034A1
公开(公告)日：2012-01-26
申请号：US13140714
申请日：2009-12-18
CPC分类号： B01J13/18 , A01N59/16 , B22F1/0018 , B22F1/02 , B82Y30/00 , A01N25/08 , A01N25/26 , A01N25/30 , A01N25/34 , A01N2300/00
摘要： A submicron structure having a silica body defining a plurality of pores, said silica body further defining an outer surface between pore openings of said plurality of pores; and having at least one silver nanocrystal within said silica body are described. Antimicrobial compositions comprising the submicron structure, and methods of killing or inhibiting growth of microbes using the submicron structure are described.
摘要翻译： 具有限定多个孔的二氧化硅主体的亚微米结构，所述二氧化硅本体还限定所述多个孔的孔口之间的外表面; 并描述了在所述二氧化硅体内具有至少一个银纳米晶体。 描述了包含亚微米结构的抗微生物组合物，以及使用亚微米结构杀死或抑制微生物生长的方法。
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公开(公告)号：US10220004B2
公开(公告)日：2019-03-05
申请号：US13550374
申请日：2012-07-16
申请人： Jeffrey I. Zink , Courtney R. Thomas , Monty Liong , Sarah Ann Henscheid , Jinwoo Cheon , Jae-Hyun Lee , Daniel P. Ferris
发明人： Jeffrey I. Zink , Courtney R. Thomas , Monty Liong , Sarah Ann Henscheid , Jinwoo Cheon , Jae-Hyun Lee , Daniel P. Ferris
摘要： A method for controlled delivery of a substance into a body includes administering a plurality of containment vessels into the body, in which each of the plurality of containment vessels includes a quantity of the substance loaded therein prior to the administering; and providing a time-varying magnetic field such that the plurality of containment vessels are exposed thereto to cause a release of at least a portion of the substance from the plurality of containment vessels. Each of the plurality of containment vessels has an average outer diameter less than about 1 μm.
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公开(公告)号：US5200334A
公开(公告)日：1993-04-06
申请号：US744524
申请日：1991-08-13
申请人： Bruce S. Dunn , Joan S. Valentine , Jeffrey I. Zink , Lisa Ellerby , Fumito Nishida , Clinton Nishida , Stacey A. Yamanaka
发明人： Bruce S. Dunn , Joan S. Valentine , Jeffrey I. Zink , Lisa Ellerby , Fumito Nishida , Clinton Nishida , Stacey A. Yamanaka
IPC分类号： C03C4/00 , C12Q1/00 , G01N33/543 , G01N33/552 , G01N33/58
CPC分类号： G01N33/552 , C03C4/0007 , C12Q1/00 , G01N33/5436 , G01N33/585
摘要： An active biological material encapsulated in a glass is formed using a sol-gel process. A metal alkoxide is mixed with water and exposed to ultrasonic energy at a pH.ltoreq.2 to form a single phase solution which is then buffered to a pH between about 5 and 7. The buffered solution is then mixed with the active biological material and the resultant gel is aged and dried. The dried product is a transparent porous glass with substantially all of the added active biological material encapsulated therein, the biological material retaining a high level of activity.
摘要翻译： 使用溶胶 - 凝胶法形成包封在玻璃中的活性生物材料。 将金属醇盐与水混合并在pH = 2下暴露于超声波能量以形成单相溶液，然后将其缓冲至约5至7之间的pH。然后将缓冲溶液与活性生物材料和 将所得凝胶老化并干燥。 干燥的产品是透明的多孔玻璃，其中包含基本上所有添加的活性生物材料，生物材料保持高水平的活性。
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