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公开(公告)号：US20230321225A1
公开(公告)日：2023-10-12
申请号：US18177714
申请日：2023-03-02
IPC分类号： A61K39/385 , A61K39/35 , G01N33/50 , G01N33/569 , A61K39/00 , A61K9/127 , A61K9/51 , A61K38/38 , A61K47/50 , A61K47/52 , A61K47/54 , A61K47/59 , A61K47/64 , A61K47/69 , B82Y5/00 , A61K39/36 , A61K31/192 , A61K9/14 , A61K38/13 , A61K38/18
CPC分类号： A61K39/385 , B82Y40/00 , G01N33/505 , G01N33/56972 , A61K39/001 , A61K39/0008 , A61K9/127 , A61K9/5146 , A61K38/38 , A61K47/50 , A61K47/52 , A61K47/544 , A61K47/593 , A61K47/643 , A61K47/69 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K39/00 , B82Y5/00 , A61K39/36 , A61K9/5115 , A61K31/192 , A61K9/14 , A61K38/13 , A61K9/5153 , A61K38/1816 , A61K9/51 , G01N2333/70517 , G01N2333/70514 , G01N2333/7051 , A61K2039/5154 , A61K2039/577 , A61K2039/55511 , A61K2039/55555 , Y02A50/30 , A61K39/35
摘要： Disclosed are synthetic nanocarrier compositions, and related methods, comprising therapeutic protein APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to therapeutic proteins.
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公开(公告)号：US11779641B2
公开(公告)日：2023-10-10
申请号：US15061204
申请日：2016-03-04
IPC分类号： A61K39/385 , A61K39/35 , G01N33/50 , G01N33/569 , A61K39/00 , A61K9/127 , A61K9/51 , A61K38/38 , A61K47/50 , A61K47/52 , A61K47/54 , A61K47/59 , A61K47/64 , A61K47/69 , B82Y5/00 , A61K39/36 , A61K31/192 , A61K9/14 , A61K38/13 , A61K38/18 , B82Y40/00
CPC分类号： A61K39/385 , A61K9/127 , A61K9/14 , A61K9/51 , A61K9/5115 , A61K9/5146 , A61K9/5153 , A61K31/192 , A61K38/13 , A61K38/1816 , A61K38/38 , A61K39/00 , A61K39/001 , A61K39/0008 , A61K39/35 , A61K39/36 , A61K47/50 , A61K47/52 , A61K47/544 , A61K47/593 , A61K47/643 , A61K47/69 , A61K47/6923 , A61K47/6929 , A61K47/6937 , B82Y5/00 , G01N33/505 , G01N33/56972 , A61K2039/5154 , A61K2039/55511 , A61K2039/55555 , A61K2039/577 , B82Y40/00 , G01N2333/7051 , G01N2333/70514 , G01N2333/70517 , Y02A50/30 , A61K39/36 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and MHC Class II-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.
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公开(公告)号：US20230147052A1
公开(公告)日：2023-05-11
申请号：US17918706
申请日：2020-04-14
IPC分类号： A61K31/436 , A61P37/06
CPC分类号： A61K31/436 , A61P37/06
摘要： Provided herein are methods and compositions related to compositions comprising synthetic nanocarriers comprising an immunosuppressant. Also provided herein are methods and compositions for inducing or increasing autophagy.
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公开(公告)号：US20230139671A1
公开(公告)日：2023-05-04
申请号：US17815877
申请日：2022-07-28
摘要： This invention relates, at least in part, to osmotic mediated release barrier-free synthetic nanocarriers and methods of production and use.
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公开(公告)号：US20230032226A1
公开(公告)日：2023-02-02
申请号：US17690437
申请日：2022-03-09
发明人： Roberto A. Maldonado
IPC分类号： A61K31/436 , A61K39/395 , A61K38/47 , A61K47/69 , A61K9/00 , A61K9/127 , A61K9/51 , C07K16/18 , C07K16/24 , C07K16/40 , A61K38/19 , A61K38/21 , A61K38/37 , A61K38/43 , A61K45/06 , A61K31/192
摘要： Disclosed are methods and related compositions for concomitantly, locally administering immunosuppressants and doses of therapeutic macromolecules for reducing Type I and Type IV hypersensitivity.
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公开(公告)号：US10434088B2
公开(公告)日：2019-10-08
申请号：US14269047
申请日：2014-05-02
IPC分类号： A61K39/395 , A61K31/436 , A61K38/19 , A61K38/21 , A61K38/37 , A61K38/43 , A61K45/06 , A61K31/192 , A61K9/00 , A61K9/127 , A61K9/51 , C07K16/18 , C07K16/24 , C07K16/40 , A61K38/47 , A61K47/69 , A61K39/00
摘要： Disclosed are compositions and methods that provide pharmacodynamic effects specific to therapeutic macromolecules. The effects may result from reduced doses of therapeutic macromolecules in combination with immunosuppressant doses. The effects may also be enhanced with such compositions.
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公开(公告)号：US20180289776A1
公开(公告)日：2018-10-11
申请号：US15917742
申请日：2018-03-11
发明人： Lloyd Johnston
摘要： Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.
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公开(公告)号：US20170349433A1
公开(公告)日：2017-12-07
申请号：US15629973
申请日：2017-06-22
CPC分类号： B82Y5/00 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937
摘要： Disclosed are synthetic nanocarrier compositions, and related methods, for treating diseases in which generating a Th1-biased immune response is desirable.
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公开(公告)号：US20160256401A1
公开(公告)日：2016-09-08
申请号：US15061096
申请日：2016-03-04
IPC分类号： A61K9/51 , A61K38/38 , A61K38/18 , A61K9/127 , A61K38/13 , A61K31/436 , A61K31/192
摘要： Disclosed are synthetic nanocarrier compositions, and related methods, comprising therapeutic protein APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to therapeutic proteins.
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10.发明申请TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE CYTOTOXIC T LYMPHOCYTE RESPONSES 审中-公开降低CYTOTOXIC T淋巴细胞反应的耐受性合成纳米颗粒公开(公告)号：US20160022650A1
公开(公告)日：2016-01-28
申请号：US14810450
申请日：2015-07-27
IPC分类号： A61K31/436 , A61K47/48 , A61K39/00
摘要： Disclosed are synthetic nanocarrier compositions, and related methods, comprising MHC Class I-restricted and/or MHC Class II-restricted epitopes associated with undesired CD8+ T cell responses and immunosuppressants that provide tolerogenic immune responses against antigens that comprise the epitopes.
摘要翻译： 公开了合成纳米载体组合物和相关方法，其包含与不想要的CD8 + T细胞应答相关的MHC I类限制性和/或MHC II类限制性表位和提供针对包含表位的抗原的耐受性免疫应答的免疫抑制剂。
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