公开(公告)号：US20090325291A1

公开(公告)日：2009-12-31

申请号：US12304707

申请日：2007-06-12

申请人： Seong Min Park ,  Young Joo Kim ,  Young Chul Choi ,  Han Oh Park ,  So Rim Choung

发明人： Seong Min Park ,  Young Joo Kim ,  Young Chul Choi ,  Han Oh Park ,  So Rim Choung

IPC分类号： C12N5/02 ,  G01N33/48 ,  C07H21/02

CPC分类号： C12N15/111 ,  C12N2320/10

摘要： A method of preparing siRNAs for selective inhibition of target mRNA isotypes comprises: dividing target mRNA isotypes intended to inhibit the expression thereof and non-target mRNA isotypes from the mRNA isotypes of a gene; allotting a common location information region (A) of exons on genome DNA corresponding to the target mRNA isotypes; allotting a location information region (B) present specifically in exons of genome DNA corresponding to target mRNAs by excluding the location information region of exons on genome DNA corresponding to non-target mRNA from the location information region (A); determining base sequences in the target mRNAs corresponding to the location information region (B); and obtaining siRNA sequences for inhibiting the determined base sequences specifically. The method of the present invention can be used to prepare siRNAs for selective inhibition of specific target mRNA isotypes in a gene having several isotypes by alternative splicing, and enables siRNA design for all the genes in genome, making good tool for functional genomics study.

摘要翻译： 制备用于选择性抑制靶mRNA同种型的siRNA的方法包括：从基因的mRNA同种型分离旨在抑制其表达的靶mRNA同种型和非靶mRNA同种型; 在对应于靶mRNA同种型的基因组DNA上分配外显子的共同位置信息区（A）; 通过从所述位置信息区域（A）中排除与非靶mRNA相对应的基因组DNA上的外显子的位置信息区，分配特定存在于与靶mRNA相对应的基因组DNA外显子中的位置信息区（B）。 确定对应于位置信息区域（B）的目标mRNA中的碱基序列; 并获得特异性抑制所确定的碱基序列的siRNA序列。 本发明的方法可用于制备用于通过选择性剪接在具有多个同种型的基因中特异性靶mRNA同种型的选择性抑制的siRNA，并且使得能够对基因组中所有基因进行siRNA设计，为功能基因组学研究提供了良好的工具。

公开(公告)号：US08644737B2

公开(公告)日：2014-02-04

申请号：US13280774

申请日：2011-10-25

申请人： Mitsuru Oikawa ,  Seong-min Park

发明人： Mitsuru Oikawa ,  Seong-min Park

IPC分类号： G03G15/08

CPC分类号： G03G15/0856 ,  G03G15/0853 ,  G03G15/0893 ,  G03G2215/0607 ,  G03G2215/0822

摘要： A developing device including a two-component developer including toner and a carrier. The developing device includes first and second developer housing portions divided by a barrier wall having first and second communication openings. A development member is disposed on the first developer housing portion, and first and second agitators are respectively disposed on the first and second developer housing portions. The developing device satisfies 1.8≦(Wa/Wb)≦3.0, wherein Wa represents a mass of the developer in the first developer housing portion and Wb represents a mass of the developer in the second developer housing portion at an equilibrium state.

摘要翻译： 一种显影装置，包括包括调色剂和载体的双组分显影剂。 显影装置包括由具有第一和第二连通开口的阻挡壁分隔的第一和第二显影剂容纳部分。 显影构件设置在第一显影剂容纳部分上，第一和第二搅拌器分别设置在第一和第二显影剂容纳部分上。 显影装置满足1.8 @（Wa / Wb）@ 3.0，其中Wa表示第一显影剂容纳部分中的显影剂的质量，Wb表示处于平衡状态的第二显影剂容纳部分中的显影剂的质量。

公开(公告)号：US07693556B2

公开(公告)日：2010-04-06

申请号：US09775529

申请日：2001-02-01

申请人： Seong-Min Park ,  Kwon-Tae Kim

发明人： Seong-Min Park ,  Kwon-Tae Kim

IPC分类号： H04M1/00

CPC分类号： H04M1/72583 ,  H04M1/274525 ,  H04M1/72519 ,  H04M1/7258

摘要： A key input method for diversifying key functions in a mobile telecommunication terminal. The method according to the present invention includes the steps of detecting whether or not a user has inputted a key, detecting whether or not the user has consecutively inputted the same key before elapse of a predetermined time, and if so, performing a function newly set according to the consecutive input of the same key. The method further includes the steps of detecting whether or not the user has inputted a key set for a scroll function, and if so, detecting whether or not the key input state of the corresponding key is maintained for a predetermined period of time, and controlling a cursor positioned at a particular item of a menu screen displayed according to a maintenance of the key input state for the predetermined period of time to be positioned at a next menu item in an opposite direction.

摘要翻译： 一种移动电信终端关键功能多样化的关键输入方法。 根据本发明的方法包括以下步骤：检测用户是否已输入密钥，检测用户是否在经过预定时间之前连续输入相同的密钥，如果是，则执行新设置的功能 根据相同键的连续输入。 该方法还包括以下步骤：检测用户是否输入了用于滚动功能的密钥集，如果是，则检测对应密钥的密钥输入状态是否保持预定时间段，并且控制 位于菜单屏幕的特定项目处的光标，所述菜单屏幕根据键输入状态的维持在预定时间段内显示，以被定位在相反方向上的下一菜单项。

公开(公告)号：US20130165875A1

公开(公告)日：2013-06-27

申请号：US13642960

申请日：2011-04-21

申请人： Young Kweon Choi ,  Jung Ju Kim ,  Seong Su Kim ,  Jung Sik Lee ,  Seong Min Park

发明人： Young Kweon Choi ,  Jung Ju Kim ,  Seong Su Kim ,  Jung Sik Lee ,  Seong Min Park

IPC分类号： A61M35/00

CPC分类号： A61K9/7061 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/4045

摘要： The present, invention relates to a transdermal absorption preparation. The transdermal absorption preparation of the present invention comprises a drug-containing adhesive layer, a drug-protective layer and a release layer, wherein the drug-containing adhesive layer contains ropinirole or a salt thereof, rubber, an adhesion-imparting resin, an antioxidant, and a transdermal absorption promoter. Also, the present invention provides a transdermal absorption preparation comprising a drug-containing adhesive layer, a drug-protective layer, and a release layer, wherein the drug-containing adhesive layer contains ropinirole or a salt thereof, acrylic rubber, an anti-crystallisation agent, and a transdermal absorption promoter. When the transdermal absorption preparation of the present invention is used for the treatment of Parkinson's disease or restless leg syndrome, no side effect due to an increase in the initial drug concentration in blood occurs and the skin penetration effect of the drug is excellent.

摘要翻译： 本发明涉及一种透皮吸收制剂。 本发明的透皮吸收制剂包含含药物的粘合剂层，药物保护层和剥离层，其中含药物的粘合剂层含有罗哌尼罗或其盐，橡胶，赋形树脂，抗氧化剂 ，和透皮吸收促进剂。 另外，本发明提供了含有药物的粘合剂层，药物保护层和剥离层的透皮吸收制剂，其中含药物的粘合剂层含有罗哌尼罗或其盐，丙烯酸橡胶，抗结晶 试剂和透皮吸收促进剂。 当本发明的经皮吸收制剂用于治疗帕金森病或不宁腿综合征时，由于血液中初始药物浓度的增加而引起副作用，药物的皮肤渗透作用优异。

公开(公告)号：US20120308269A1

公开(公告)日：2012-12-06

申请号：US13280774

申请日：2011-10-25

申请人： Mitsuru OIKAWA ,  Seong-min PARK

发明人： Mitsuru OIKAWA ,  Seong-min PARK

IPC分类号： G03G15/08

CPC分类号： G03G15/0856 ,  G03G15/0853 ,  G03G15/0893 ,  G03G2215/0607 ,  G03G2215/0822

摘要： A developing device including a two-component developer including toner and a carrier. The developing device includes first and second developer housing portions divided by a barrier wall having first and second communication openings. A development member is disposed on the first developer housing portion, and first and second agitators are respectively disposed on the first and second developer housing portions. The developing device satisfies 1.8≦(Wa/Wb)≦3.0, wherein Wa represents a mass of the developer in the first developer housing portion and Wb represents a mass of the developer in the second developer housing portion at an equilibrium state.

摘要翻译： 一种显影装置，包括包括调色剂和载体的双组分显影剂。 显影装置包括由具有第一和第二连通开口的阻挡壁分隔的第一和第二显影剂容纳部分。 显影构件设置在第一显影剂容纳部分上，第一和第二搅拌器分别设置在第一和第二显影剂容纳部分上。 显影装置满足1.8＆nlE;（Wa / Wb）＆nlE; 3.0，其中Wa表示第一显影剂容纳部分中的显影剂的质量，Wb表示处于平衡状态的第二显影剂容纳部分中的显影剂的质量。

公开(公告)号：US20090155904A1

公开(公告)日：2009-06-18

申请号：US11721303

申请日：2005-12-08

申请人： Young-Chul Choi ,  Han Oh Park ,  Sorim Choung ,  Young Joo Kim ,  Sang Soo Kim ,  Seong-min Park ,  Sang-Cheol Kim ,  Gyuman Yoon ,  Kyoung Oak Choi ,  Hyo Jin Kang

发明人： Young-Chul Choi ,  Han Oh Park ,  Sorim Choung ,  Young Joo Kim ,  Sang Soo Kim ,  Seong-min Park ,  Sang-Cheol Kim ,  Gyuman Yoon ,  Kyoung Oak Choi ,  Hyo Jin Kang

IPC分类号： C12N5/02

CPC分类号： C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/11 ,  G16B20/00

摘要： A inhibition method of target mRNA expression includes: (a) obtaining binding energy of a double combination section on a dsRNA sequence of all combination comprising complementary nucleotides to a random target mRNA; (b) dividing the binding energy into four sections on the dsRNA sequence of each combination to obtain a difference of the mean binding energy between each section and convert into a score of a relative combination energy pattern; (c) selecting siRNA whose inhibition efficiency to target mRNA is expected to be high by applying the converted score to the dsRNA sequence with other factors that affect the efficiency of siRNA; and (d) inhibiting target mRNA expression using the selected siRNA. As a result, a researcher or an experimenter can analyze patterns of a relative binding energy on base sequences of unknown siRNA without actual experiments to determine whether the siRNA is effective or ineffective rapidly, thereby design and production efficiency of siRNA can be maximized and target mRNA can be effectively inhibited with efficient siRNA to the target mRNA.

摘要翻译： 靶mRNA表达的抑制方法包括：（a）获得双组合切片对包含与随机靶mRNA的互补核苷酸的所有组合的dsRNA序列的结合能; （b）将结合能分成每个组合的dsRNA序列上的四个部分，以获得每个部分之间的平均结合能的差异，并转换成相对组合能量模式的得分; （c）通过将影响siRNA效率的其它因素应用于dsRNA序列的转化得分，选择siRNA靶向mRNA的抑制效率高的siRNA; 和（d）使用所选择的siRNA抑制靶mRNA表达。 因此，研究人员或实验者可以分析未知siRNA基因序列相对结合能力的模式，无需实际实验，可以快速确定siRNA是否有效或无效，从而可以使siRNA的设计和生产效率最大化，靶mRNA 可以有效地抑制靶mRNA的有效siRNA。