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    METHOD OF INHIBITING EXPRESSION OF TARGET MRNA USING SIRNA CONSISTING OF NUCLEOTIDE SEQUENCE COMPLEMENTARY TO SAID TARGET MRNA
    1.
    发明申请
    METHOD OF INHIBITING EXPRESSION OF TARGET MRNA USING SIRNA CONSISTING OF NUCLEOTIDE SEQUENCE COMPLEMENTARY TO SAID TARGET MRNA 审中-公开
    抑制靶向MRNA的表达的方法使用SIRNA包含核酸序列与鉴定目标MRNA相符

    公开(公告)号：US20090155904A1

    公开(公告)日：2009-06-18

    申请号：US11721303

    申请日：2005-12-08

    申请人： Young-Chul Choi ,  Han Oh Park ,  Sorim Choung ,  Young Joo Kim ,  Sang Soo Kim ,  Seong-min Park ,  Sang-Cheol Kim ,  Gyuman Yoon ,  Kyoung Oak Choi ,  Hyo Jin Kang

    发明人： Young-Chul Choi ,  Han Oh Park ,  Sorim Choung ,  Young Joo Kim ,  Sang Soo Kim ,  Seong-min Park ,  Sang-Cheol Kim ,  Gyuman Yoon ,  Kyoung Oak Choi ,  Hyo Jin Kang

    IPC分类号： C12N5/02

    CPC分类号： C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/11 ,  G16B20/00

    摘要： A inhibition method of target mRNA expression includes: (a) obtaining binding energy of a double combination section on a dsRNA sequence of all combination comprising complementary nucleotides to a random target mRNA; (b) dividing the binding energy into four sections on the dsRNA sequence of each combination to obtain a difference of the mean binding energy between each section and convert into a score of a relative combination energy pattern; (c) selecting siRNA whose inhibition efficiency to target mRNA is expected to be high by applying the converted score to the dsRNA sequence with other factors that affect the efficiency of siRNA; and (d) inhibiting target mRNA expression using the selected siRNA. As a result, a researcher or an experimenter can analyze patterns of a relative binding energy on base sequences of unknown siRNA without actual experiments to determine whether the siRNA is effective or ineffective rapidly, thereby design and production efficiency of siRNA can be maximized and target mRNA can be effectively inhibited with efficient siRNA to the target mRNA.

    摘要翻译： 靶mRNA表达的抑制方法包括：（a）获得双组合切片对包含与随机靶mRNA的互补核苷酸的所有组合的dsRNA序列的结合能; （b）将结合能分成每个组合的dsRNA序列上的四个部分，以获得每个部分之间的平均结合能的差异，并转换成相对组合能量模式的得分; （c）通过将影响siRNA效率的其它因素应用于dsRNA序列的转化得分，选择siRNA靶向mRNA的抑制效率高的siRNA; 和（d）使用所选择的siRNA抑制靶mRNA表达。 因此，研究人员或实验者可以分析未知siRNA基因序列相对结合能力的模式，无需实际实验，可以快速确定siRNA是否有效或无效，从而可以使siRNA的设计和生产效率最大化，靶mRNA 可以有效地抑制靶mRNA的有效siRNA。

    METHOD OF PREPARING siRNAs FOR SELECTIVE INHIBITION OF TARGET mRNA ISOTYPES
    2.
    发明申请
    METHOD OF PREPARING siRNAs FOR SELECTIVE INHIBITION OF TARGET mRNA ISOTYPES 审中-公开
    制备用于选择性抑制靶标mRNA同功酶的siRNA的方法

    公开(公告)号：US20090325291A1

    公开(公告)日：2009-12-31

    申请号：US12304707

    申请日：2007-06-12

    申请人： Seong Min Park ,  Young Joo Kim ,  Young Chul Choi ,  Han Oh Park ,  So Rim Choung

    发明人： Seong Min Park ,  Young Joo Kim ,  Young Chul Choi ,  Han Oh Park ,  So Rim Choung

    IPC分类号： C12N5/02 ,  G01N33/48 ,  C07H21/02

    CPC分类号： C12N15/111 ,  C12N2320/10

    摘要： A method of preparing siRNAs for selective inhibition of target mRNA isotypes comprises: dividing target mRNA isotypes intended to inhibit the expression thereof and non-target mRNA isotypes from the mRNA isotypes of a gene; allotting a common location information region (A) of exons on genome DNA corresponding to the target mRNA isotypes; allotting a location information region (B) present specifically in exons of genome DNA corresponding to target mRNAs by excluding the location information region of exons on genome DNA corresponding to non-target mRNA from the location information region (A); determining base sequences in the target mRNAs corresponding to the location information region (B); and obtaining siRNA sequences for inhibiting the determined base sequences specifically. The method of the present invention can be used to prepare siRNAs for selective inhibition of specific target mRNA isotypes in a gene having several isotypes by alternative splicing, and enables siRNA design for all the genes in genome, making good tool for functional genomics study.

    摘要翻译： 制备用于选择性抑制靶mRNA同种型的siRNA的方法包括：从基因的mRNA同种型分离旨在抑制其表达的靶mRNA同种型和非靶mRNA同种型; 在对应于靶mRNA同种型的基因组DNA上分配外显子的共同位置信息区（A）; 通过从所述位置信息区域（A）中排除与非靶mRNA相对应的基因组DNA上的外显子的位置信息区，分配特定存在于与靶mRNA相对应的基因组DNA外显子中的位置信息区（B）。 确定对应于位置信息区域（B）的目标mRNA中的碱基序列; 并获得特异性抑制所确定的碱基序列的siRNA序列。 本发明的方法可用于制备用于通过选择性剪接在具有多个同种型的基因中特异性靶mRNA同种型的选择性抑制的siRNA，并且使得能够对基因组中所有基因进行siRNA设计，为功能基因组学研究提供了良好的工具。

    Method and apparatus for locating a source of damage in a large composite material structure
    3.
    发明授权
    Method and apparatus for locating a source of damage in a large composite material structure 有权
    在大型复合材料结构中定位损伤源的方法和装置

    公开(公告)号：US09523661B2

    公开(公告)日：2016-12-20

    申请号：US13817153

    申请日：2011-08-17

    申请人： Dong Jin Yoon ,  Byeong Hee Han ,  Young Joo Kim

    发明人： Dong Jin Yoon ,  Byeong Hee Han ,  Young Joo Kim

    IPC分类号： G01N29/44 ,  G01N29/06 ,  G01N29/14 ,  G01N29/42

    CPC分类号： G01N29/44 ,  G01N29/069 ,  G01N29/14 ,  G01N29/42 ,  G01N2291/0231 ,  G01N2291/2693

    摘要： Provided is a method of locating a damage source of a wind turbine blade for tracking a damage source location of a blade used in a wind power generator, and more particularly, a method of locating a damage source of a wind turbine blade and an apparatus thereof in a large composite material structure capable of accurately locating a damage source even in a large composite material structure by detecting defects using contour maps written based on elastic wave energy value. The method of locating a damage source of the wind turbine blade according to the present invention can accurately locate the damage source even in the large composite material structure using at least two materials unlike the related art and can use a smaller number of AE sensor than the related art.

    摘要翻译： 提供了一种定位用于跟踪风力发电机中使用的叶片的损伤源位置的风力涡轮机叶片的损坏源的方法，更具体地，定位风力涡轮机叶片的损坏源的方法及其装置 在能够通过基于弹性波能量值写入的轮廓图检测缺陷的情况下，即使在大的复合材料结构中也能够精确地定位损伤源的大型复合材料结构。 根据本发明的定位风力涡轮机叶片的损伤源的方法即使在大型复合材料结构中也可以使用与现有技术不同的至少两种材料来精确地定位损伤源，并且可以使用比例少的AE传感器 相关技术

    Pipe latch circuit and semiconductor memory device using the same
    6.
    发明授权
    Pipe latch circuit and semiconductor memory device using the same 有权
    管路锁存电路和使用其的半导体存储器件

    公开(公告)号：US08023339B2

    公开(公告)日：2011-09-20

    申请号：US12459106

    申请日：2009-06-26

    申请人： Youk Hee Kim ,  Bok Rim Ko ,  Young Joo Kim

    发明人： Youk Hee Kim ,  Bok Rim Ko ,  Young Joo Kim

    IPC分类号： G11C11/00

    CPC分类号： G11C7/1051 ,  G11C7/1039 ,  G11C7/106 ,  G11C7/1066 ,  G11C7/22 ,  G11C7/222

    摘要： A pipe latch circuit comprises a reset signal generating unit which receives a read-write flag signal and a read period signal and generates a reset signal, wherein the reset signal is enabled upon entry into a write operation or after all data are outputted to an outside upon read operation, an input/output control signal generating unit which generates a plurality of input control signals and output control signals in response to a read strobe signal and a clock signal, and is reset in response to the reset signal, and a pipe latch unit which latches inputted data in response to the input control signals and outputs the latched data in response to the output control signals.

    摘要翻译： 管锁存电路包括复位信号产生单元，其接收读写标志信号和读周期信号并产生复位信号，其中复位信号在进入写操作或所有数据输出到外部之后被使能 在读取操作时，输入/输出控制信号产生单元，其响应于读取选通信号和时钟信号产生多个输入控制信号并输出​​控制信号，并且响应于复位信号被复位，并且管闩锁 单元，其响应于输入控制信号锁存输入数据，并响应于输出控制信号输出锁存数据。

    Optical pickup
    7.
    发明授权
    Optical pickup 失效
    光学拾音

    公开(公告)号：US06353587B1

    公开(公告)日：2002-03-05

    申请号：US09219991

    申请日：1998-12-23

    申请人： Young Chi Hong ,  Young Joo Kim ,  Beom Seok Lee

    发明人： Young Chi Hong ,  Young Joo Kim ,  Beom Seok Lee

    IPC分类号： G11B700

    CPC分类号： G11B7/1353 ,  G11B7/1275 ,  G11B7/1356 ,  G11B7/1365 ,  G11B2007/0006

    摘要： A first light source of an optical pickup emits a first laser beam having a first predetermined wavelength. A second light source emits a second laser beam that substantially perpendicularly crosses the first laser beam and has a second predetermined wavelength different from the first predetermined wavelength. A holographic beam splitter is slopingly disposed where the laser beams cross. The holographic beam splitter has a hologram diffractive surface on one surface and a coating layer on another surface for being penetrated by and reflecting the laser beams at a first predetermined ratio. A flat beam splitter is arranged on a first path of the laser beams from the holographic beam splitter to be penetrated by and reflect the laser beams at a second predetermined ratio. A collimator lens is arranged on a second path of the laser beams from the flat beam splitter to shape the laser beams. An objective lens focuses the shaped laser beams at least upon an optical disc. A photodiode reads out recorded and error information from the laser beams when reflected from the optical disc.

    摘要翻译： 光学拾取器的第一光源发射具有第一预定波长的第一激光束。 第二光源发射基本上垂直于第一激光束并且具有与第一预定波长不同的第二预定波长的第二激光束。 全息分束器被倾斜地设置在激光束交叉的地方。 全息分束器在一个表面上具有全息衍射表面，在另一个表面上具有用于以第一预定比例穿透和反射激光束的另一表面上的涂层。 平面分束器布置在来自全息分束器的激光束的第一路径上，以第二预定比率穿透和反射激光束。 准直透镜布置在来自平坦分束器的激光束的第二路径上以形成激光束。 物镜将成形的激光束至少聚焦在光盘上。 当从光盘反射时，光电二极管从激光束读出记录和误差信息。

    Array substrate for liquid crystal display device and method of fabricating the same
    8.
    发明授权
    Array substrate for liquid crystal display device and method of fabricating the same 有权
    液晶显示装置用阵列基板及其制造方法

    公开(公告)号：US08183567B2

    公开(公告)日：2012-05-22

    申请号：US12985144

    申请日：2011-01-05

    申请人： Su Hyuk Kang ,  Dai Yun Lee ,  Yong In Park ,  Young Joo Kim

    发明人： Su Hyuk Kang ,  Dai Yun Lee ,  Yong In Park ,  Young Joo Kim

    IPC分类号： H01L31/00 ,  H01L29/10 ,  H01L20/04

    CPC分类号： H01L29/42384 ,  G02F1/13454 ,  H01L27/124 ,  H01L27/14621 ,  H01L29/78621

    摘要： An array substrate for an LCD device includes a first TFT including a first semiconductor layer, a first gate electrode, wherein the first gate electrode is directly over the first semiconductor layer; a first protrusion extending from the first gate electrode along an edge of the first semiconductor layer; a second TFT including a second semiconductor layer, a second gate electrode, wherein the second gate electrode is directly over the second semiconductor layer; a second protrusion extending from the second gate electrode along an edge of the second semiconductor layer; a third TFT connected to crossed data and gate lines including a third semiconductor layer, a third gate electrode, wherein the third gate electrode is directly over the third semiconductor layer; a third protrusion extending from the third gate electrode along an edge of the third semiconductor layer; and a pixel electrode.

    摘要翻译： 用于LCD器件的阵列衬底包括：第一TFT，包括第一半导体层，第一栅电极，其中第一栅电极直接位于第一半导体层上; 从所述第一栅电极沿着所述第一半导体层的边缘延伸的第一突起; 包括第二半导体层的第二TFT，第二栅电极，其中所述第二栅电极直接在所述第二半导体层上; 从所述第二栅电极沿着所述第二半导体层的边缘延伸的第二突起; 连接到交叉数据的第三TFT和包括第三半导体层，第三栅电极的栅极线，其中第三栅极直接在第三半导体层上方; 从所述第三栅电极沿着所述第三半导体层的边缘延伸的第三突起; 和像素电极。

    SILICON CRYSTALLIZATION APPARATUS AND SILICON CRYSTALLIZATION METHOD THEREOF
    9.
    发明申请
    SILICON CRYSTALLIZATION APPARATUS AND SILICON CRYSTALLIZATION METHOD THEREOF 有权
    硅结晶装置及其结晶方法

    公开(公告)号：US20100255663A1

    公开(公告)日：2010-10-07

    申请号：US12767407

    申请日：2010-04-26

    申请人： Yun Ho JUNG ,  Young Joo Kim

    发明人： Yun Ho JUNG ,  Young Joo Kim

    IPC分类号： H01L21/20

    CPC分类号： H01L21/0268 ,  B23K26/0622 ,  B23K26/0823 ,  B23K26/0853 ,  B23K37/0461 ,  C30B11/005 ,  C30B29/06 ,  H01L21/2026 ,  H01L21/68

    摘要： A silicon crystallization method renders it is possible to form alignment key without additional photolithography, and to adjust a substrate to a correct position by sensing a deviation of the substrate when the substrate is loaded. The silicon crystallization method includes aligning the substrate by sensing a fixed substrate with a sensing device, and moving and/or rotating a stage, wherein the sensing device faces toward an edge of the substrate to directly sense the edge of the substrate; forming alignment keys on predetermined portions of a non-display area of the substrate by correspondingly placing a mask for formation of an alignment key above the substrate; and crystallizing an amorphous silicon by correspondingly providing a mask for crystallization above the substrate.

    摘要翻译： 硅结晶方法使得可以在没有附加光刻的情况下形成对准键，并且通过在衬底被加载时感测衬底的偏差来将衬底调整到正确的位置。 硅结晶方法包括通过感测固定基板与感测装置对基板进行定位，以及移动和/或旋转载物台，其中感测装置面向基板的边缘以直接感测基板的边缘; 通过相应地放置用于在基板上方形成对准键的掩模，在基板的非显示区域的预定部分上形成对准键; 并通过相应地在衬底上提供用于结晶的掩模来结晶非晶硅。

    DC/DC CONVERTER
    10.
    发明申请
    DC/DC CONVERTER 失效
    DC / DC转换器

    公开(公告)号：US20090141519A1

    公开(公告)日：2009-06-04

    申请号：US12128297

    申请日：2008-05-28

    申请人： Young Gun HONG ,  Young Joo Kim ,  Hyun Jung Kim ,  Dong Seong Oh

    发明人： Young Gun HONG ,  Young Joo Kim ,  Hyun Jung Kim ,  Dong Seong Oh

    IPC分类号： H02M3/335

    CPC分类号： H02M3/33576 ,  H02M2001/007

    摘要： Provided is a DC/DC converter including a power supply unit that includes a transformer having one primary side and a plurality of secondary sides and outputs a plurality of driving voltages for driving a load; and a constant current converting unit that is connected to one secondary side and a low-voltage stage of another secondary side adjacent to the one secondary side among the plurality of secondary sides of the transformer and boosts a driving voltage output from the one secondary side.

    摘要翻译： 提供一种DC / DC转换器，其包括电源单元，该电源单元包括具有一个初级侧和多个次级侧的变压器，并且输出用于驱动负载的多个驱动电压; 以及恒流电流转换单元，其连接到所述变压器的所述多个次级侧中与所述一个次级侧相邻的另一次级侧的一个次级侧和低压级，并且提升从所述一个次级侧输出的驱动电压。