公开(公告)号：US06255317B1

公开(公告)日：2001-07-03

申请号：US09233325

申请日：1999-01-20

申请人： Jung Ho Kim ,  Tae Neung Jhong ,  Young Ki Paik ,  Joon Seo Park ,  Eui Deok Kim ,  You Suk Lee ,  Seung Un Kim

发明人： Jung Ho Kim ,  Tae Neung Jhong ,  Young Ki Paik ,  Joon Seo Park ,  Eui Deok Kim ,  You Suk Lee ,  Seung Un Kim

IPC分类号： C07D48704

CPC分类号： C07D471/04 ,  C07D491/04

摘要： The present invention provides a cholesterol biosynthesis inhibitor which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, a compound of formula (1) below and the use of an extract or the compound of formula (1) for treating hypercholesterolaemia or hyperlipidaemia. The inhibitor comprises an extract obtained by extracting Corydalis Turtschaninowii Besser with a solvent, or an organic layers obtained by partitioning an extract from Corydalis Turtschaninowii Besser with an organic solvent. The extract contains 7,8,13,13&agr;-tetrahydrocoridaline or its derivative, as the active ingredients, which specifically inhibits the enzyme which is involved in the distal pathway of the cholesterol biosynthesis. R1 and R2 which may be the same or different from each other, represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms or both of R1 and R2 represent a methylenedioxy group; R3 represents a hydrogen atom; R4 and R5 which may be the same or different from each other, represent a hydroxy group, a hydroxyethylamino group or an alkoxy group having 1 to 4 carbon atoms; R6 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a cycloalkylalkyl group having 1 to 7 carbon atoms, a holoalkyl group having 1 to 4 carbon atoms, an ethoxycarbonyl group, an ethoxycarbonylmethyl group, a hydroxycarbonylmethyl group, 1-ethoxycarbonylethyl group, or 2-valerolactonyl group; and z represents a halogen atom.

摘要翻译： 本发明提供一种胆固醇生物合成抑制剂，其特异性抑制参与胆固醇生物合成的远端途径的甾醇14-还原酶，下式（1）的化合物和提取物或式（1）化合物用于 治疗高胆固醇血症或高脂血症。 抑制剂包括通过用溶剂提取紫茎泽兰植物提取物获得的提取物或通过用有机溶剂分离来自紫堇（Corydalis Turtschaninowii Besser）的提取物获得的有机层。 提取物含有7,8,13,13α-四氢花青苷或其衍生物作为活性成分，其特异性抑制参与胆固醇生物合成的远端途径的酶.R1和R2可以相同或不同 另一个表示羟基或具有1至4个碳原子的烷氧基，或者R 1和R 2都表示亚甲二氧基; R 3表示氢原子; R 4和R 5可以相同或不同，表示羟基 基团，羟乙基氨基或具有1〜4个碳原子的烷氧基; R6表示氢原子，碳原子数1〜8的烷基，碳原子数3〜8的烯基，碳原子数为1〜7的环烷基烷基 原子，具有1至4个碳原子的全烷基，乙氧基羰基，乙氧基羰基甲基，羟基羰基甲基，1-乙氧基羰基乙基或2-戊内酰基; 和z表示卤素原子。

公开(公告)号：US08020707B2

公开(公告)日：2011-09-20

申请号：US12364126

申请日：2009-02-02

申请人： Seung-Un Kim ,  Sa-Mun Hong ,  Wang-Keun Kim ,  Sang-Gon Lee ,  Sang-Yeoul Hwang

发明人： Seung-Un Kim ,  Sa-Mun Hong ,  Wang-Keun Kim ,  Sang-Gon Lee ,  Sang-Yeoul Hwang

IPC分类号： B04C5/24

CPC分类号： B04C5/13 ,  B04C5/081 ,  B24B57/00

摘要： A cyclone used in a separator apparatus includes a body and a vortex finder. The body includes an inlet passageway, a cylindrical passageway connected to the inlet passageway, and a conical passageway connected to the cylindrical passageway. The cylindrical passageway has an upper end through which first particles in a fluid are exhausted, and a lower end. The conical passageway has an upper end connected to the lower end of the cylindrical passageway, and an opened lower end through which second particles having a specific gravity greater than that of the first particle are exhausted. The vortex finder is connected to the upper end of the cylindrical passageway. A first exhaust passageway is vertically formed in the vortex finder so that the first particles spirally ascend through the first exhaust passageway from the cylindrical passageway.

摘要翻译： 在分离器装置中使用的旋风分离器包括主体和涡流探测器。 主体包括入口通道，连接到入口通道的圆柱形通道和连接到圆柱形通道的锥形通道。 圆柱形通道具有上端，流体中的第一颗粒通过该上端排出，下端。 锥形通道具有连接到圆柱形通道的下端的上端，并且具有比第一颗粒的比重更大的第二颗粒的​​打开的下端被排出。 涡流探测器连接到圆柱形通道的上端。 第一排气通道垂直地形成在旋涡取样器中，使得第一颗粒从圆柱形通道螺旋地通过第一排气通道上升。

公开(公告)号：US20090145813A1

公开(公告)日：2009-06-11

申请号：US12364126

申请日：2009-02-02

申请人： Seung-Un KIM ,  Sa-Mun HONG ,  Wang-Keun KIM ,  Sang-Gon LEE ,  Sang-Yeoul HWANG

发明人： Seung-Un KIM ,  Sa-Mun HONG ,  Wang-Keun KIM ,  Sang-Gon LEE ,  Sang-Yeoul HWANG

IPC分类号： B03B7/00 ,  B03B5/34 ,  B03B5/60

CPC分类号： B04C5/13 ,  B04C5/081 ,  B24B57/00

摘要： A cyclone used in a separator apparatus includes a body and a vortex finder. The body includes an inlet passageway, a cylindrical passageway connected to the inlet passageway, and a conical passageway connected to the cylindrical passageway. The cylindrical passageway has an upper end through which first particles in a fluid are exhausted, and a lower end. The conical passageway has an upper end connected to the lower end of the cylindrical passageway, and an opened lower end through which second particles having a specific gravity greater than that of the first particle are exhausted. The vortex finder is connected to the upper end of the cylindrical passageway. A first exhaust passageway is vertically formed in the vortex finder so that the first particles spirally ascend through the first exhaust passageway from the cylindrical passageway.

摘要翻译： 在分离器装置中使用的旋风分离器包括主体和涡流探测器。 主体包括入口通道，连接到入口通道的圆柱形通道和连接到圆柱形通道的锥形通道。 圆柱形通道具有上端，流体中的第一颗粒通过该上端排出，下端。 锥形通道具有连接到圆柱形通道的下端的上端，并且具有比第一颗粒的比重更大的第二颗粒的​​打开的下端被排出。 涡流探测器连接到圆柱形通道的上端。 第一排气通道垂直地形成在旋涡取样器中，使得第一颗粒从圆柱形通道螺旋地通过第一排气通道上升。

公开(公告)号：US06239139B1

公开(公告)日：2001-05-29

申请号：US09233323

申请日：1999-01-20

申请人： Jung Ho Kim ,  Tae Neung Jhong ,  Young Ki Paik ,  Joon Seo Park ,  Eui Deok Kim ,  You Suk Lee ,  Seung Un Kim

发明人： Jung Ho Kim ,  Tae Neung Jhong ,  Young Ki Paik ,  Joon Seo Park ,  Eui Deok Kim ,  You Suk Lee ,  Seung Un Kim

IPC分类号： C07D491056

CPC分类号： C07D471/04 ,  C07D491/04

摘要： The present invention provides a cholesterol biosynthesis inhibitor which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, a compound of formula (1) below and the use of an extract or the compound of formula (1) for treating hypercholesterolaemia or hyperlipidaemia. The inhibitor comprises an extract obtained by extracting Corydalis Turtschaninowii Besser with a solvent, or an organic layers obtained by partitioning an extract from Corydalis Turtschaninowii Besser with an organic solvent. The extract contains 7,8,13,13&agr;-tetrahydrocoridaline or its derivative, as the active ingredients, which specifically inhibits the enzyme which is involved in the distal pathway of the cholesterol biosynthesis. R1 and R2 which may be the same or different from each other, represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms or both of R1 and R2 represent a methylenedioxy group; R3 represents a hydrogen atom; R4 and R5 which may be the same or different from each other, represent a hydroxy group, a hydroxyethylamino group or an alkoxy group having 1 to 4 carbon atoms; R6 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a cycloalkylalkyl group having 1 to 7 carbon atoms, a holoalkyl group having 1 to 4 carbon atoms, an ethoxycarbonyl group, an ethoxycarbonylmethyl group, a hydroxycarbonylmethyl group, 1-ethoxycarbonylethyl group, or 2-valerolactonyl group.

摘要翻译： 本发明提供了一种胆固醇生物合成抑制剂，其特异性抑制参与胆固醇生物合成的远端途径的甾醇14-还原酶，以下式（1）的化合物以及提取物或式（1）化合物用于 治疗高胆固醇血症或高脂血症。 抑制剂包括通过用溶剂提取紫茎泽兰植物提取物获得的提取物或通过用有机溶剂分离来自紫堇（Corydalis Turtschaninowii Besser）的提取物获得的有机层。 提取物含有7,8,13,13α-四氢花青苷或其衍生物作为活性成分，其特异性抑制参与胆固醇生物合成的远端途径的酶.R1和R2可以相同或不同 另一个表示羟基或具有1至4个碳原子的烷氧基，或者R 1和R 2都表示亚甲二氧基; R 3表示氢原子; R 4和R 5可以相同或不同，表示羟基 基团，羟乙基氨基或具有1〜4个碳原子的烷氧基; R6表示氢原子，碳原子数1〜8的烷基，碳原子数3〜8的烯基，碳原子数为1〜7的环烷基烷基 原子，具有1至4个碳原子的全烷基，乙氧基羰基，乙氧基羰基甲基，羟基羰基甲基，1-乙氧基羰基乙基或2-戊内酰基。

公开(公告)号：US6030978A

公开(公告)日：2000-02-29

申请号：US208641

申请日：1998-12-10

申请人： Jung Ho Kim ,  Tae Neung Jhong ,  Young Ki Paik ,  Joon Seo Park ,  Eui Deok Kim ,  You Suk Lee ,  Seung Un Kim

发明人： Jung Ho Kim ,  Tae Neung Jhong ,  Young Ki Paik ,  Joon Seo Park ,  Eui Deok Kim ,  You Suk Lee ,  Seung Un Kim

IPC分类号： A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/4375 ,  A61K31/47 ,  A61K36/71 ,  A61P31/00 ,  A61P31/10 ,  C07D455/03 ,  C07D471/04 ,  C07D491/056 ,  A61K31/44

CPC分类号： C07D455/00 ,  C07D471/04

摘要： The antifungal formulation comprising the novel compounds of the following chemical formulae (I) and (II) exhibit in vitro antifungal activity against fungi including cutaneous filamentous fungus, such as Epidermophyton, Microsporum, Trichophyton, Sporothrix schenckii, Aspergillus or Candida. The formulation of the present invention exhibit in vitro antifungal activity at the concentration of 1-100 .mu.g/ml. ##STR1## wherein R.sup.1, R.sup.2, and R.sup.4 may be the same or different, and represent C.sub.1 -C.sub.5 alkoxy, R.sup.3 represents hydrogen or C.sub.1 -C.sub.10 alkyl, A.sup.- represents inorganic acid ion, organic acid ion or halide, R.sup.5 represents hydrogen, pyridylmethyl, substituted pyridylmethyl or a group having the following chemical formula(XI) ##STR2## wherein Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4 and Z.sup.5 may be the same or different and represent hydrogen, halogen, C.sub.1 -C.sub.5 alkyl, trifluoromethyl, phenyl, substituted phenyl, nitro, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylamino, acetylamino, C.sub.1 -C.sub.8 trialkyl ammonium, guanidinyl, methylthio, ethylthio, trifluoromethoxy, hydroxy, phenoxy, vinyl, carboxyl and C.sub.1 -C.sub.2 alkoxycarbonyl group.

摘要翻译： 包含以下化学式（I）和（II）的新化合物的抗真菌制剂表现出对真菌的体外抗真菌活性，包括皮肤丝状真菌，例如表皮癣菌，微孢子虫，毛癣菌，斯曲霉，曲霉或假丝酵母。 本发明的制剂以1-100μg/ ml的浓度显示体外抗真菌活性。 其中R1，R2和R4可以相同或不同，表示C1-C5烷氧基，R3表示氢或C1-C10烷基，A-表示无机酸离子，有机酸离子或卤化物，R5表示氢，吡啶基甲基，取代 吡啶基甲基或具有以下化学式（XI）的基团，其中Z 1，Z 2，Z 3，Z 4和Z 5可以相同或不同，表示氢，卤素，C 1 -C 5烷基，三氟甲基，苯基，取代的苯基，硝基， C4烷氧基，C1-C4烷基氨基，乙酰氨基，C1-C8三烷基铵，胍基，甲硫基，乙硫基，三氟甲氧基，羟基，苯氧基，乙烯基，羧基和C1-C2烷氧基羰基。

公开(公告)号：US07503458B2

公开(公告)日：2009-03-17

申请号：US11344774

申请日：2006-01-31

申请人： Seung-Un Kim ,  Sa-Mun Hong ,  Wang-Keun Kim ,  Sang-Gon Lee ,  Sang-Yeoul Hwang

发明人： Seung-Un Kim ,  Sa-Mun Hong ,  Wang-Keun Kim ,  Sang-Gon Lee ,  Sang-Yeoul Hwang

IPC分类号： B04C5/24 ,  B04C5/13

CPC分类号： B04C5/13 ,  B04C5/081 ,  B24B57/00

摘要： A cyclone used in a separator apparatus includes a body and a vortex finder. The body includes an inlet passageway, a cylindrical passageway connected to the inlet passageway, and a conical passageway connected to the cylindrical passageway. The cylindrical passageway has an upper end through which first particles in a fluid are exhausted, and a lower end. The conical passageway has an upper end connected to the lower end of the cylindrical passageway, and an opened lower end through which second particles having a specific gravity greater than that of the first particle are exhausted. The vortex finder is connected to the upper end of the cylindrical passageway. A first exhaust passageway is vertically formed in the vortex finder so that the first particles spirally ascend through the first exhaust passageway from the cylindrical passageway.

摘要翻译： 在分离器装置中使用的旋风分离器包括主体和涡流探测器。 主体包括入口通道，连接到入口通道的圆柱形通道和连接到圆柱形通道的锥形通道。 圆柱形通道具有上端，流体中的第一颗粒通过该上端排出，下端。 锥形通道具有连接到圆柱形通道的下端的上端，并且具有比第一颗粒的比重更大的第二颗粒的​​打开的下端被排出。 涡流探测器连接到圆柱形通道的上端。 第一排气通道垂直地形成在旋涡取样器中，使得第一颗粒从圆柱形通道螺旋地通过第一排气通道上升。

公开(公告)号：US06910954B2

公开(公告)日：2005-06-28

申请号：US10145806

申请日：2002-05-16

申请人： Sue-Ryeon Kim ,  Seung-Un Kim ,  Seung-Ki Chae ,  Je-Gu Lee ,  Seung-Hoon Ahn

发明人： Sue-Ryeon Kim ,  Seung-Un Kim ,  Seung-Ki Chae ,  Je-Gu Lee ,  Seung-Hoon Ahn

IPC分类号： B01F3/12 ,  B01F15/00 ,  B24B37/00 ,  B24B57/02 ,  H01L21/304 ,  B24B1/00

CPC分类号： B24B57/02 ,  B01F3/1221 ,  B01F3/1271 ,  B01F15/00123 ,  B01F2003/1285

摘要： A computer-controlled slurry supplying apparatus for providing abrasive slurry to a chemical mechanical polishing (CMP) machine in a semiconductor manufacturing process preferably comprises a storage portion for accepting and storing a quantity of undiluted slurry, a mixing portion for accepting undiluted slurry from the storage portion and mixing with a diluting solution to created a diluted slurry, a supply portion for holding the diluted slurry, and at least one point-of-use mixing unit for mixing at least one chemical additive to the diluted slurry at or near a dispensing nozzle at the point of application. Each of the above portions of the slurry supplying apparatus further includes a re-circulation means for keep solutions in a mixed and agitated state. A method for using the slurry supplying apparatus comprises steps of controllably operating various valves, pumps, and sensors to maintain a desired slurry composition and flow rate.

摘要翻译： 一种用于在半导体制造工艺中向化学机械抛光（CMP）机器提供磨料浆料的计算机控制的浆料供应装置优选地包括用于接收和存储一定数量的未稀释浆料的存储部分，用于从储存器接收未稀释浆料的混合部分 并与稀释溶液混合以产生稀释的浆料，用于保存稀释浆料的供应部分和至少一个使用点的混合单元，用于将至少一种化学添加剂与分配喷嘴处或附近的稀释浆料混合 在应用点。 浆料供给装置的上述各部分还包括用于将溶液保持在混合和搅拌状态的再循环装置。 使用浆料供给装置的方法包括可控地操作各种阀，泵和传感器以维持所需的浆料组成和流速的步骤。

公开(公告)号：US6038699A

公开(公告)日：2000-03-21

申请号：US184851

申请日：1998-11-03

申请人： Youn-soo Han ,  Hyeung-ki Kim ,  Hyun-joon Kim ,  Seung-un Kim

发明人： Youn-soo Han ,  Hyeung-ki Kim ,  Hyun-joon Kim ,  Seung-un Kim

IPC分类号： A41D13/00 ,  A41D13/02 ,  A41D13/12 ,  A41D27/28 ,  A41D1/06

CPC分类号： A41D13/1263 ,  A41D13/02 ,  A41D27/28 ,  Y10S2/01

摘要： A smock to be worn by a clean room operator includes an upper material part for covering the upper body of the operator, a lower material part for covering the lower body of the operator, wherein the upper material part and the lower material part are integrally formed. An air passage within the smock connects the upper material part and the lower material part, and a discharge part is in flow communication with the air passage for venting the air within the smock.

摘要翻译： 由洁净室操作者穿的工作服包括用于覆盖操作者的上身的上部材料部分，用于覆盖操作者下体的下部材料部分，其中上部材料部分和下部材料部分整体形成 。 工作区内的空气通道连接上部材料部分和下部材料部分，排出部分与空气通道流通，以便排出工作服内的空气。

公开(公告)号：US20060175234A1

公开(公告)日：2006-08-10

申请号：US11344774

申请日：2006-01-31

申请人： Seung-Un Kim ,  Sa-Mun Hong ,  Wang-Keun Kim ,  Sang-Gon Lee ,  Sang-Yeoul Hwang

发明人： Seung-Un Kim ,  Sa-Mun Hong ,  Wang-Keun Kim ,  Sang-Gon Lee ,  Sang-Yeoul Hwang

IPC分类号： B04C5/00

CPC分类号： B04C5/13 ,  B04C5/081 ,  B24B57/00

摘要： A cyclone used in a separator apparatus includes a body and a vortex finder. The body includes an inlet passageway, a cylindrical passageway connected to the inlet passageway, and a conical passageway connected to the cylindrical passageway. The cylindrical passageway has an upper end through which first particles in a fluid are exhausted, and a lower end. The conical passageway has an upper end connected to the lower end of the cylindrical passageway, and an opened lower end through which second particles having a specific gravity greater than that of the first particle are exhausted. The vortex finder is connected to the upper end of the cylindrical passageway. A first exhaust passageway is vertically formed in the vortex finder so that the first particles spirally ascend through the first exhaust passageway from the cylindrical passageway.

公开(公告)号：US06814835B2

公开(公告)日：2004-11-09

申请号：US10084198

申请日：2002-02-28

申请人： Seung-un Kim ,  Seung-ki Chae ,  Je-Gu Lee ,  Sue-Ryeon Kim

发明人： Seung-un Kim ,  Seung-ki Chae ,  Je-Gu Lee ,  Sue-Ryeon Kim

IPC分类号： C23F102

CPC分类号： B24B37/04 ,  B24B57/02 ,  C23F3/00 ,  H01L21/31053 ,  H01L21/3212 ,  Y10T137/0971

摘要： An apparatus for supplying chemicals in a chemical mechanical polishing (CMP) process includes a plurality of chemical solution supply sources for supplying different chemical solutions in a pump-less manner by using a pressure applied at the chemical solution supply sources, each supply source having an associated feed line, re-circulating line, and means for measuring and controlling flow rates of the chemical solutions supplied through the feed lines. The chemical solutions are delivered via a plurality of delivery lines to a mixer, thereby providing a mixed chemical solution to a chemical injection part of a polishing apparatus. Each means for measuring and controlling flow rates is mounted in the feed lines.