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7 条记录 (耗时 0.013 秒)

    Silencing of TGFβ type II receptor expression by siRNA
    1.
    发明授权
    Silencing of TGFβ type II receptor expression by siRNA 失效
    TGF和bgr的沉默 通过siRNA的II型受体表达

    公开(公告)号：US08067389B2

    公开(公告)日：2011-11-29

    申请号：US12505911

    申请日：2009-07-20

    申请人： Nalin M. Kumar ,  Beatrice Yue ,  Shahid Siddiqui ,  Asrar B. Malik ,  Jose S. Pulido

    发明人： Nalin M. Kumar ,  Beatrice Yue ,  Shahid Siddiqui ,  Asrar B. Malik ,  Jose S. Pulido

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C12N5/00

    CPC分类号： C12N15/1138 ,  C12N2310/14

    摘要： The present application is directed to siRNA-based silencing of the type II receptor of TGFβ. siRNAs that target this receptor abrogate the receptor protein and transcript, TGFβ-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGFβ type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.

    摘要翻译： 本申请涉及TGF-bgr的II型受体的基于siRNA的沉默。 靶向该受体的siRNA消除受体蛋白和转录物，TGFβb介导的过程如纤连蛋白装配和细胞迁移也受到抑制，本发明的分子有效降低炎症反应和基质沉积。 这些研究结果表明，siRNA可以在体外和体内成功传递，以调节TGF-bgr; II型受体水平和调节伤口反应。 利用本发明的发现的方法和组合物具有广泛的应用，从眼睛疾病的治疗延伸到整个身体的其他器官和组织。

    Beta chain-associated regulator of apoptosis
    2.
    发明授权
    Beta chain-associated regulator of apoptosis 失效
    β链相关的凋亡调节因子

    公开(公告)号：US07662924B2

    公开(公告)日：2010-02-16

    申请号：US11267986

    申请日：2005-11-07

    申请人： Oscar Colamonici ,  Shahid Siddiqui

    发明人： Oscar Colamonici ,  Shahid Siddiqui

    IPC分类号： C07K17/00 ,  G01N33/53

    CPC分类号： C07K16/30 ,  C07K14/4747 ,  G01N33/5011 ,  G01N2510/00

    摘要： The present invention provides β-subunit-Associated Regulator of Apoptosis, or BARA, polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, non-human transgenic animals, devices and methods for producing BARA polypeptides. The invention further provides compositions comprising BARA nucleic acids, polypeptides, and fusions or derivatives thereof. The invention further provides methods for treating, preventing, or ameliorating a medical disease, condition, or disorder comprising administering BARA or BARA compositions, as well as methods of diagnosing a pathological condition related to BARA. Still further, the invention provides methods of modulating levels of BARA expression and methods of determining whether a compound stimulates or inhibits BARA polypeptide activity or BARA polypeptide production.

    摘要翻译： 本发明提供了β亚单位相关的细胞凋亡调控因子或BARA多肽和编码该调控因子的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞，非人转基因动物，用于产生BARA多肽的装置和方法。 本发明还提供了包含BARA核酸，多肽及其融合物或衍生物的组合物。 本发明还提供了治疗，预防或改善包括施用BARA或BARA组合物的医学疾病，病症或病症的方法，以及诊断与BARA相关的病理状况的方法。 此外，本发明提供了调节BARA表达水平的方法以及确定化合物是否刺激或抑制BARA多肽活性或BARA多肽生产的方法。

    SILENCING OF TGF BETA TYPE II RECEPTOR EXPRESSION BY SIRNA
    3.
    发明申请
    SILENCING OF TGF BETA TYPE II RECEPTOR EXPRESSION BY SIRNA 失效
    由SIRNA沉默TGFβⅡ型受体表达

    公开(公告)号：US20090318537A1

    公开(公告)日：2009-12-24

    申请号：US12505911

    申请日：2009-07-20

    申请人： NALIN M. KUMAR ,  BEATRICE YUE ,  SHAHID SIDDIQUI ,  ASRAR B. MALIK ,  JOSE S. PULIDO

    发明人： NALIN M. KUMAR ,  BEATRICE YUE ,  SHAHID SIDDIQUI ,  ASRAR B. MALIK ,  JOSE S. PULIDO

    IPC分类号： A61K31/7105 ,  C07H21/02

    CPC分类号： C12N15/1138 ,  C12N2310/14

    摘要： The present application is directed to siRNA-based silencing of the type II receptor of TGFβ. siRNAs that target this receptor abrogate the receptor protein and transcript, TGFβ-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGFβ type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.

    摘要翻译： 本申请涉及TGFbeta的II型受体的基于siRNA的沉默。 靶向该受体的siRNA消除受体蛋白和转录物，TGFβ介导的过程如纤连蛋白装配和细胞迁移也受到抑制，本发明的分子有效降低炎症反应和基质沉积。 这些研究结果表明siRNA可以在体外和体内成功递送，以调节TGFbeta II型受体水平并调节伤口应答。 利用本发明的发现的方法和组合物具有广泛的应用，从眼睛疾病的治疗延伸到整个身体的其他器官和组织。

    Silencing of tgf-beta receptor type II expression by sirna
    6.
    发明申请
    Silencing of tgf-beta receptor type II expression by sirna 审中-公开
    sirna沉默tgf-β受体II型表达

    公开(公告)号：US20060229266A1

    公开(公告)日：2006-10-12

    申请号：US10567958

    申请日：2004-08-10

    申请人： Nalin Kumar ,  Beatrice Yue ,  Shahid Siddiqui ,  Asrar Malik ,  Jose Pulido

    发明人： Nalin Kumar ,  Beatrice Yue ,  Shahid Siddiqui ,  Asrar Malik ,  Jose Pulido

    IPC分类号： A61K48/00 ,  C07H21/02

    CPC分类号： C12N15/1138 ,  C12N2310/14

    摘要： The present application is directed to siRNA-based silencing of the type II receptor of TGFβ. siRNAs that target this receptor abrogate the receptor protein and transcript, TGFβ-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGFβ type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.

    摘要翻译： 本申请涉及TGFbeta的II型受体的基于siRNA的沉默。 靶向该受体的siRNA消除受体蛋白和转录物，TGFβ介导的过程如纤连蛋白装配和细胞迁移也受到抑制，本发明的分子有效降低炎症反应和基质沉积。 这些研究结果表明siRNA可以在体外和体内成功递送，以调节TGFbeta II型受体水平并调节伤口应答。 利用本发明的发现的方法和组合物具有广泛的应用，从眼睛疾病的治疗延伸到整个身体的其他器官和组织。

    Beta chain-associated regulator of apoptosis
    7.
    发明申请
    Beta chain-associated regulator of apoptosis 失效
    β链相关的凋亡调节因子

    公开(公告)号：US20060121505A1

    公开(公告)日：2006-06-08

    申请号：US11267986

    申请日：2005-11-07

    申请人： Oscar Colamonici ,  Shahid Siddiqui

    发明人： Oscar Colamonici ,  Shahid Siddiqui

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30 ,  C12N1/21

    CPC分类号： C07K16/30 ,  C07K14/4747 ,  G01N33/5011 ,  G01N2510/00

    摘要： The present invention provides β-subunit-Associated Regulator of Apoptosis, or BARA, polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, non-human transgenic animals, devices and methods for producing BARA polypeptides. The invention further provides compositions comprising BARA nucleic acids, polypeptides, and fusions or derivatives thereof. The invention further provides methods for treating, preventing, or ameliorating a medical disease, condition, or disorder comprising administering BARA or BARA compositions, as well as methods of diagnosing a pathological condition related to BARA. Still further, the invention provides methods of modulating levels of BARA expression and methods of determining whether a compound stimulates or inhibits BARA polypeptide activity or BARA polypeptide production.

    摘要翻译： 本发明提供了β亚单位相关的细胞凋亡调控因子或BARA多肽和编码该调控因子的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞，非人转基因动物，用于产生BARA多肽的装置和方法。 本发明还提供了包含BARA核酸，多肽及其融合物或衍生物的组合物。 本发明还提供了治疗，预防或改善包括施用BARA或BARA组合物的医学疾病，病症或病症的方法，以及诊断与BARA相关的病理状况的方法。 此外，本发明提供了调节BARA表达水平的方法以及确定化合物是否刺激或抑制BARA多肽活性或BARA多肽生产的方法。