公开(公告)号：US20190133968A1

公开(公告)日：2019-05-09

申请号：US16097348

申请日：2017-04-27

申请人： SHANXI MEDICAL UNIVERSITY ,  SHANXI MEDICAL UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

发明人： Qingshan Li ,  Xiue Feng ,  Yuanlin Zhang ,  Lingge Han ,  Rongrong Chang

IPC分类号： A61K31/12 ,  A61K31/5377 ,  A61P13/12

摘要： Medical applications of 2,5′-dibromo-4,5,2′-trihydroxyldiphenylmethanone and 4,5,2′-tris(4-morpholinemethanoyl)-2,5′-dichlorobenzophenone are provided, particularly applications in preparation of drugs respectively for resisting type II diabetic nephropathy and for treating acute pyelonephritis and chronic nephritis. Moreover, two drugs respectively with the above two compounds as the active ingredient are provided, respectively for resisting the type II diabetic nephropathy and for treating the acute pyelonephritis and the chronic nephritis. Both of the two compounds are able to effectively improve renal functions of model rats suffered from the type II diabetic nephropathy, the acute pyelonephritis, and the chronic nephritis, showing an important application prospect in resisting the diabetic nephropathy and treating the acute pyelonephritis and the chronic nephritis.

公开(公告)号：US20210329894A1

公开(公告)日：2021-10-28

申请号：US17125368

申请日：2020-12-17

申请人： Shanxi Medical University

发明人： Qiao NIU ,  Xiujun QIN ,  Liang LI

IPC分类号： A01K67/027

摘要： The present disclosure relates to a method for preparing an Alzheimer's disease (AD) animal model, including: selecting healthy male human ApoE4 transgenic mice, and intraperitoneally injecting a 4 mmol/L Al(mal)3 solution at a volume of 10 ml/kg, with aluminum exposure for 60 days, and interval time of 2 days for every 5 days, to obtain an AD animal model co-induced by genetic and environmental factors which are interacted without being simply superimposed. The AD animal model established according to the method of the examples in the present disclosure can express the characteristic pathological changes of AD and has the characteristics of learning and memory impairment. The AD animal model provided by the present disclosure can be used for drug screening and AD mechanism research, and has the advantages of stable properties, prominent reproducibility, easy operation, and low cost.

公开(公告)号：US20240287119A1

公开(公告)日：2024-08-29

申请号：US18192609

申请日：2023-03-29

申请人： Shanxi Medical University

发明人： Keming YUN ,  Zhuoyi WANG ,  Ying WANG ,  Yuping LU ,  Xianlian WANG ,  Hongliang SU ,  Chao ZHANG ,  Zhiwen WEI ,  Lele WANG ,  Ruili WANG

IPC分类号： C07H15/203 ,  B01J21/18 ,  B01J23/44 ,  G01N33/53

CPC分类号： C07H15/203 ,  B01J21/18 ,  B01J23/44 ,  G01N33/5308 ,  G01N2800/42

摘要： The present disclosure provides a 3-phenoxybenzoic acid-glucuronic acid conjugate, and a preparation method and use thereof, and belongs to the technical field of pesticide detection. Compared with 3-phenoxybenzoic acid, the 3-phenoxybenzoic acid-glucuronic acid conjugate provided by the present disclosure features structural stability, high specificity, long limit of detection, and high content in urine, and can better serve as a marker that identifies whether an organism is killed due to pyrethroid pesticide poisoning. Namely, the 3-phenoxybenzoic acid-glucuronic acid conjugate can detect whether a toxicant (pyrethroid pesticides) is taken antemortem or exposed postmortem, and has an excellent application prospect in pyrethroid pesticide detection. The present disclosure provides a preparation method of a 3-phenoxybenzoic acid-glucuronic acid conjugate. The preparation method provided by the present disclosure features high product yield, simple operation, wide raw material sources, low costs, and suitability for industrial production.

公开(公告)号：US20230384334A1

公开(公告)日：2023-11-30

申请号：US18449654

申请日：2023-08-14

申请人： Shanxi Medical University

发明人： Keming Yun ,  Lele Wang ,  Wei Zhang ,  Ruilong Wang ,  Yongli Guang ,  Daming Zhang ,  Chao Zhang ,  Meng Hu ,  Zhiwen Wei ,  Wenfang Zhang ,  Zhongyuan Guo

IPC分类号： G01N33/98

CPC分类号： G01N33/98

摘要： A method for calculating drinking time includes: drawing a plurality of blood samples within 0 to 120 h upon start of drinking, testing concentrations of alcohol, EtG and EtS in the blood samples, and obtaining an average concentration ratio CEtG/CEtS; obtaining a quadratic regression equation by fitting using the average concentration ratio CEtG/CEtS as an abscissa and sampling time as an ordinate; and measuring CEtG/CEtS of blood samples under test, obtaining a relationship between the drinking time and the CEtG/CEtS based on the quadratic regression equation, and calculating the drinking time.

公开(公告)号：US20220099849A1

公开(公告)日：2022-03-31

申请号：US17421683

申请日：2019-01-10

申请人： SHANXI MEDICAL UNIVERSITY

发明人： Sijin LI ,  Haiyan LIU ,  Gangqiang ZHA

IPC分类号： G01T1/24

摘要： Provided is a CZT semiconductor activity meter and an activity measuring device, which relate to the field of medical apparatus and instruments. The CZT semiconductor activity meter includes a shell, a CZT probe, a package substrate and a processing module, wherein the CZT probe is arranged on an end of the shell, the package substrate is arranged at the middle part of the shell and abuts against an inner wall of the shell, the CZT probe is connected to one side of the package substrate, the other side of the package substrate and the inner wall of the shell together form a package inner cavity, and the processing module is accommodated in the package inner cavity and connected to the package substrate. The CZT semiconductor activity meter has a small volume, is convenient to operate, does not require manual control during detection, and can be used at room temperature.

公开(公告)号：US20230365498A1

公开(公告)日：2023-11-16

申请号：US18357985

申请日：2023-07-24

申请人： SHANXI MEDICAL UNIVERSITY

发明人： Yi ZHANG ,  Huan XUE ,  Min ZHANG ,  ZhiHong LU ,  Linping ZHI ,  Zhitong WEN ,  Lijuan CUI ,  Tao BAI ,  Yunfeng LIU

IPC分类号： C07D207/46 ,  A61P3/10

CPC分类号： C07D207/46 ,  A61P3/10

摘要： The present invention relates to an anisomycin derivative represented by general formula (I) or pharmaceutically acceptable salts, solvates and stereoisomers thereof. According to the present invention, it is found that anisomycin and derivatives thereof have the effect of promoting insulin secretion under high blood sugar concentrations, and can treat diabetes and prevent the occurrence of hypoglycemia. It is found, by studying its mechanism of action, that the anisomycin derivative is highly related to GLP-1R, indicating that the anisomycin derivative is a small molecule GLP-1R agonist, which can effectively treat a variety of GLP-1R-mediated diseases including obesity and diabetes, and has good commercial application prospects and scientific research value.

公开(公告)号：US11619752B2

公开(公告)日：2023-04-04

申请号：US17421683

申请日：2019-01-10

申请人： SHANXI MEDICAL UNIVERSITY

发明人： Sijin Li ,  Haiyan Liu ,  Gangqiang Zha

IPC分类号： G01T1/24

摘要： Provided is a CZT semiconductor activity meter and an activity measuring device, which relate to the field of medical apparatus and instruments. The CZT semiconductor activity meter includes a shell, a CZT probe, a package substrate and a processing module, wherein the CZT probe is arranged on an end of the shell, the package substrate is arranged at the middle part of the shell and abuts against an inner wall of the shell, the CZT probe is connected to one side of the package substrate, the other side of the package substrate and the inner wall of the shell together form a package inner cavity, and the processing module is accommodated in the package inner cavity and connected to the package substrate. The CZT semiconductor activity meter has a small volume, is convenient to operate, does not require manual control during detection, and can be used at room temperature.