-
公开(公告)号：US08846036B2
公开(公告)日：2014-09-30
申请号：US12329357
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Robert N. Ziemann , Frank C. Grenier , Ryan F. Workman , Lowell Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Frank C. Grenier , Ryan F. Workman
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
摘要翻译： 本发明涉及对糖基化哺乳动物NGAL特异的抗体，以及制备和使用这些抗体的方法。
-
2.发明授权Recombinant antibodies against hepatitis C virus and methods of obtaining and using same 失效针对丙型肝炎病毒的重组抗体及其获得和使用方法公开(公告)号：US07858752B2
公开(公告)日：2010-12-28
申请号：US11633810
申请日：2006-12-05
申请人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
发明人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
CPC分类号： G01N33/5767 , C07K16/109 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92
摘要： Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
摘要翻译： 提供了对丙型肝炎（HCV）抗原蛋白特异性的重组抗体，包括嵌合抗体。 重组抗体特异性结合HCV蛋白的诊断相关区域，因此适合用作检测HCV的诊断试剂，和/或用于检测HCV的测定中的标准化试剂或阳性对照试剂。 重组抗体也可用于治疗或预防HCV感染。
-
公开(公告)号：US20100015637A1
公开(公告)日：2010-01-21
申请号：US12485114
申请日：2009-06-16
申请人： Susan E. Brophy , Lianli Chi , Saul A. Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Lowell J Tyner , Zhiguang Yu , Robert N. Ziemann
发明人： Susan E. Brophy , Lianli Chi , Saul A. Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Lowell J Tyner , Zhiguang Yu , Robert N. Ziemann
CPC分类号： C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
摘要： The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
摘要翻译： 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
-
公开(公告)号：US20090269777A1
公开(公告)日：2009-10-29
申请号：US12104410
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
IPC分类号： G01N33/53
CPC分类号： G01N33/566
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
-
公开(公告)号：US20100227775A1
公开(公告)日：2010-09-09
申请号：US12784548
申请日：2010-05-21
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann
CPC分类号： G01N33/6872 , G01N2333/96486 , G01N2400/00 , G01N2800/347
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
摘要翻译： 本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。 除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。
-
公开(公告)号：US20090123946A1
公开(公告)日：2009-05-14
申请号：US12329331
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , C07K16/18 , G01N33/573 , G01N2333/58 , G01N2800/347
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
摘要翻译： 本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。 除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。
-
公开(公告)号：US09073984B2
公开(公告)日：2015-07-07
申请号：US13353678
申请日：2012-01-19
申请人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
发明人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
IPC分类号： G01N33/53 , C07K16/00 , C07K16/20 , G01N33/569
CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00
摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
摘要翻译： 本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。
-
8.发明申请RECOMBINANT ANTIBODIES AGAINST HEPATITIS C VIRUS AND METHODS OF OBTAINING AND USING SAME 有权抗重度丙型肝炎病毒的重组抗体及其获取和使用方法公开(公告)号：US20110263436A1
公开(公告)日：2011-10-27
申请号：US12951735
申请日：2010-11-22
申请人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
发明人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
CPC分类号： G01N33/5767 , C07K16/109 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92
摘要： Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
摘要翻译： 提供了对丙型肝炎（HCV）抗原蛋白特异性的重组抗体，包括嵌合抗体。 重组抗体特异性结合HCV蛋白的诊断相关区域，因此适合用作检测HCV的诊断试剂，和/或用于检测HCV的测定中的标准化试剂或阳性对照试剂。 重组抗体也可用于治疗或预防HCV感染。
-
9.发明申请SOLUBLE FMS-LIKE TYROSINE KINASE-1 (sFLT-1) ANTIBODY AND RELATED COMPOSITION, KIT, METHODS OF USING, AND MATERIALS AND METHOD FOR MAKING 失效可溶性FMS-样酪氨酸激酶-1（sFLT-1）抗体及相关组合物，试剂盒，使用方法，材料和制备方法公开(公告)号：US20100266575A1
公开(公告)日：2010-10-21
申请号：US12643847
申请日：2009-12-21
申请人： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner , Zhiguang Yu
发明人： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner , Zhiguang Yu
IPC分类号： A61K39/395 , C07K16/40 , G01N33/573 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , A61P9/12
CPC分类号： C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
摘要翻译： 特异性结合sFlt-1或其片段的分离的抗体，其具有（i）包含SEQ ID NO：2的氨基酸序列的可变重结构域，（ii）包含SEQ ID NO：2的氨基酸序列的可变轻区域区域 SEQ ID NO：4，或（iii）（i）和（ii）两者，药物组合物和包含这种抗体的试剂盒，制备这种抗体的方法，确定sFlt- 1或其片段，治疗或预防性地需要sFlt-1拮抗剂的方法，分离的核酸，其包含编码（i）SEQ ID NO：1的氨基酸序列的核苷酸序列， 2，（ii）SEQ ID NO：4或（iii）（i）和（ii），任选地作为载体的一部分，以及包含并表达这种核酸的宿主细胞。
-
公开(公告)号：US20090263894A1
公开(公告)日：2009-10-22
申请号：US12329357
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
摘要翻译： 本发明涉及对糖基化哺乳动物NGAL特异的抗体，以及制备和使用这些抗体的方法。
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.025 秒)
