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公开(公告)号：US20070207152A1
公开(公告)日：2007-09-06
申请号：US11595625
申请日：2006-11-09
申请人： Susan Brophy , Joan Tyner , Bailin Tu , Mary Pinkus , Jessie Shih
发明人： Susan Brophy , Joan Tyner , Bailin Tu , Mary Pinkus , Jessie Shih
IPC分类号： A61K39/395 , C07K16/28 , G01N33/567
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975
摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
摘要翻译： 本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于产生和选择所述抗体的方法，人脑利钠肽的免疫测定或人脑利钠肽片段 所述抗体和含有所述抗体的治疗组合物。
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公开(公告)号：US20050053924A1
公开(公告)日：2005-03-10
申请号：US10940262
申请日：2004-09-14
申请人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
发明人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
IPC分类号： G01N33/569 , C07K14/16 , C07K16/10 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12Q1/70 , C12N5/06
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
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3.发明授权Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making 失效可溶性FMS样酪氨酸激酶-1（sFLT-1）抗体及相关组成，试剂盒，使用方法，材料及制备方法公开(公告)号：US08349325B2
公开(公告)日：2013-01-08
申请号：US12643847
申请日：2009-12-21
申请人： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner, legal representative , Zhiguang Yu
发明人： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Zhiguang Yu
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
摘要翻译： 特异性结合sFlt-1或其片段的分离的抗体，其具有（i）包含SEQ ID NO：2的氨基酸序列的可变重结构域，（ii）包含SEQ ID NO：2的氨基酸序列的可变轻区域区域 SEQ ID NO：4，或（iii）（i）和（ii）两者，药物组合物和包含这种抗体的试剂盒，制备这种抗体的方法，确定sFlt- 1或其片段，治疗或预防性地需要sFlt-1拮抗剂的方法，分离的核酸，其包含编码（i）SEQ ID NO：1的氨基酸序列的核苷酸序列， 2，（ii）SEQ ID NO：4或（iii）（i）和（ii），任选地作为载体的一部分，以及包含并表达这种核酸的宿主细胞。
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公开(公告)号：US20050058994A1
公开(公告)日：2005-03-17
申请号：US10940261
申请日：2004-09-14
申请人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
发明人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
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公开(公告)号：US20050053610A1
公开(公告)日：2005-03-10
申请号：US10940392
申请日：2004-09-14
申请人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
发明人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
IPC分类号： G01N33/569 , C07K14/16 , C07K16/10 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12Q1/70 , A61K39/42 , C12N5/06
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
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公开(公告)号：US20050031624A1
公开(公告)日：2005-02-10
申请号：US10940162
申请日：2004-09-14
申请人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
发明人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
IPC分类号： G01N33/569 , C07K14/16 , C07K16/10 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12Q1/70 , A61K39/42 , C07K16/14 , C12N5/06
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
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7.发明申请公开(公告)号：US20050025772A1
公开(公告)日：2005-02-03
申请号：US10940237
申请日：2004-09-14
申请人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
发明人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
IPC分类号： G01N33/569 , C07K14/16 , C07K16/10 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , A61K39/42 , C12N5/06 , C12Q1/70
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
摘要翻译： 本发明涉及可用于检测人类免疫缺陷病毒（HIV）的新型单克隆抗体。 这些抗体表现出非常高的灵敏度，非常宽的特异性范围，并且结合新的共享的非交叉反应性表位。 特别地，本发明的单克隆抗体可用于检测患者样品中的HIV-1抗原和HIV-2核心抗原。
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8.发明申请SOLUBLE FMS-LIKE TYROSINE KINASE-1 (sFLT-1) ANTIBODY AND RELATED COMPOSITION, KIT, METHODS OF USING, AND MATERIALS AND METHOD FOR MAKING 失效可溶性FMS-样酪氨酸激酶-1（sFLT-1）抗体及相关组合物，试剂盒，使用方法，材料和制备方法公开(公告)号：US20100266575A1
公开(公告)日：2010-10-21
申请号：US12643847
申请日：2009-12-21
申请人： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner , Zhiguang Yu
发明人： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner , Zhiguang Yu
IPC分类号： A61K39/395 , C07K16/40 , G01N33/573 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , A61P9/12
CPC分类号： C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
摘要翻译： 特异性结合sFlt-1或其片段的分离的抗体，其具有（i）包含SEQ ID NO：2的氨基酸序列的可变重结构域，（ii）包含SEQ ID NO：2的氨基酸序列的可变轻区域区域 SEQ ID NO：4，或（iii）（i）和（ii）两者，药物组合物和包含这种抗体的试剂盒，制备这种抗体的方法，确定sFlt- 1或其片段，治疗或预防性地需要sFlt-1拮抗剂的方法，分离的核酸，其包含编码（i）SEQ ID NO：1的氨基酸序列的核苷酸序列， 2，（ii）SEQ ID NO：4或（iii）（i）和（ii），任选地作为载体的一部分，以及包含并表达这种核酸的宿主细胞。
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公开(公告)号：US20060183154A1
公开(公告)日：2006-08-17
申请号：US11135040
申请日：2005-05-23
申请人： Jessie Shih , Joan Tyner , Matthew Matias , Mary Pinkus , Susan Brophy , David Dagfal , David Hawksworth , Bryan Tieman
发明人： Jessie Shih , Joan Tyner , Matthew Matias , Mary Pinkus , Susan Brophy , David Dagfal , David Hawksworth , Bryan Tieman
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.
摘要翻译： 本发明涉及在测试样品中定量人BNP或人BNP片段时使用所述抗体特异性结合人BNP和免疫测定的抗体。
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公开(公告)号：US20050053925A1
公开(公告)日：2005-03-10
申请号：US10940344
申请日：2004-09-14
申请人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
发明人： Sheng Lou , Jeffrey Hunt , John Konrath , Xiaoxing Qiu , James Scheffel , Joan Tyner
IPC分类号： G01N33/569 , C07K14/16 , C07K16/10 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12Q1/70 , C12N5/06
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
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