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公开(公告)号：US20160032410A1
公开(公告)日：2016-02-04
申请号：US14514305
申请日：2014-10-14
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman Leipzig , Thomas Bock Tuebingen , William Sievert , Sharon Lewin
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman Leipzig , Thomas Bock Tuebingen , William Sievert , Sharon Lewin
IPC分类号： C12Q1/70
CPC分类号： C12Q1/706 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 疫苗和诊断测定也在本文中考虑。
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公开(公告)号：US20100075299A1
公开(公告)日：2010-03-25
申请号：US12303942
申请日：2007-06-04
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
CPC分类号： C12Q1/706 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 疫苗和诊断测定也在本文中考虑。
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公开(公告)号：US08859198B2
公开(公告)日：2014-10-14
申请号：US12303942
申请日：2007-06-04
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
CPC分类号： C12Q1/706 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 疫苗和诊断测定也在本文中考虑。
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