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公开(公告)号：US08859198B2
公开(公告)日：2014-10-14
申请号：US12303942
申请日：2007-06-04
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
CPC分类号： C12Q1/706 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 疫苗和诊断测定也在本文中考虑。
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公开(公告)号：US20160032410A1
公开(公告)日：2016-02-04
申请号：US14514305
申请日：2014-10-14
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman Leipzig , Thomas Bock Tuebingen , William Sievert , Sharon Lewin
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman Leipzig , Thomas Bock Tuebingen , William Sievert , Sharon Lewin
IPC分类号： C12Q1/70
CPC分类号： C12Q1/706 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 疫苗和诊断测定也在本文中考虑。
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公开(公告)号：US20100075299A1
公开(公告)日：2010-03-25
申请号：US12303942
申请日：2007-06-04
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
CPC分类号： C12Q1/706 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 疫苗和诊断测定也在本文中考虑。
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4.发明授权Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof 有权具有抗病毒核苷剂抗性的乙型肝炎病毒的变体及其应用公开(公告)号：US08211443B2
公开(公告)日：2012-07-03
申请号：US11911097
申请日：2006-04-04
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Paul Desmond , Peter William Angus
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Paul Desmond , Peter William Angus
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/5258 , C12N7/00 , C12N2730/10122 , C12Q1/706 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。
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5.发明授权Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof 有权具有抗病毒核苷剂抗性的乙型肝炎病毒的变体及其应用公开(公告)号：US07887813B2
公开(公告)日：2011-02-15
申请号：US11932410
申请日：2007-10-31
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Paul Desmond , Peter William Angus
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Paul Desmond , Peter William Angus
CPC分类号： C12N15/86 , A61K2039/525 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12Q1/706
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。
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6.发明申请VARIANTS OF HEPATITIS B VIRUS WITH RESISTANCE TO ANTI-VIRAL NUCLEOSIDE AGENTS AND APPLICATIONS THEREOF 有权乙型肝炎病毒对抗病毒核苷酸药物的抗性变异及其应用公开(公告)号：US20080176218A1
公开(公告)日：2008-07-24
申请号：US11932410
申请日：2007-10-31
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Paul Desmond , Peter William Angus
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Paul Desmond , Peter William Angus
CPC分类号： C12N15/86 , A61K2039/525 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12Q1/706
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。
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公开(公告)号：US09682109B2
公开(公告)日：2017-06-20
申请号：US11913106
申请日：2006-10-20
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Peter William Angus
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Peter William Angus
CPC分类号： A61K35/76 , C12N7/00 , C12N2730/10132 , C12Q1/18
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to agents such as nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
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公开(公告)号：US20080274083A1
公开(公告)日：2008-11-06
申请号：US11913106
申请日：2006-10-20
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Peter William Angus
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayres , Margaret Littlejohn , Peter William Angus
CPC分类号： A61K35/76 , C12N7/00 , C12N2730/10132 , C12Q1/18
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to agents such as nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
摘要翻译： 本发明一般涉及对药剂例如核苷或核苷酸类似物或其它DNA聚合酶拮抗剂的敏感性降低和/或与免疫试剂降低的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物或其它DNA聚合酶拮抗剂表现出完全或部分抗性和/或降低与病毒表面成分抗体的相互作用的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。
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9.发明授权Viral variants with altered susceptibility to nucleoside analogs and uses thereof 有权对核苷类似物具有改变的易感性的病毒变体及其用途公开(公告)号：US07989162B2
公开(公告)日：2011-08-02
申请号：US12142917
申请日：2008-06-20
申请人： Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Peter William Angus , William Sievert
发明人： Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Peter William Angus , William Sievert
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2730/10122 , C12Q1/706
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷类似物表现完全或部分抗性和/或与抗体对抗病毒表面成分降低的相互作用的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体筛选能够抑制病毒感染，复制和/或释放的药剂。
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10.发明申请Viral Variants With Altered Susceptibility To Nucleoside Analogs And Uses Thereof 有权具有改变的核苷类似物及其用途的易感性的病毒变体公开(公告)号：US20090081667A1
公开(公告)日：2009-03-26
申请号：US12142917
申请日：2008-06-20
申请人： Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Peter William Angus , William Sievert
发明人： Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Peter William Angus , William Sievert
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2730/10122 , C12Q1/706
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷类似物表现完全或部分抗性和/或与抗体对抗病毒表面成分降低的相互作用的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体筛选能够抑制病毒感染，复制和/或释放的药剂。
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