公开(公告)号：US6117864A

公开(公告)日：2000-09-12

申请号：US889807

申请日：1997-07-08

Applicant: Yutaka Morita ,  Noritoshi Koyama ,  Shigemitsu Ohsawa

Inventor： Yutaka Morita ,  Noritoshi Koyama ,  Shigemitsu Ohsawa

IPC: A61K9/06 ,  A61K9/00 ,  A61K9/08 ,  A61K9/107 ,  A61K31/55 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P17/04 ,  A61P27/16 ,  A61P37/08

CPC classification number: A61K9/0014 ,  A61K31/55 ,  A61K47/12 ,  Y10S514/947

Abstract: Azelastine hydrochloride is combined certain fatty acids. The stability and absorbability of the composition is enhanced.

Abstract translation: 盐酸阿曲斯汀组合某些脂肪酸。 组合物的稳定性和吸收性得到提高。

公开(公告)号：US4767624A

公开(公告)日：1988-08-30

申请号：US838559

申请日：1986-03-11

Applicant: Shinichi Okuyama ,  Kazumaro Furuse ,  Shigemitsu Ohsawa

Inventor： Shinichi Okuyama ,  Kazumaro Furuse ,  Shigemitsu Ohsawa

IPC: A61K31/12 ,  A61P17/00 ,  A61P43/00 ,  C07C50/28 ,  A61K37/48

CPC classification number: A61K31/12

Abstract: A decubital remedy suitable for cutaneous administration contains ubidecarenone as an effective ingredient. The decubital remedy, which may preferably take the form of a cream, lotion or ointment, is effective in reducing decubitus-related severe pain and restoring the tissue damaged by decubitus. It is applicable even to patients who are unable to take drugs orally by themselves due to dyscrasia or cranial nerve disorders. It is also free of such cumbersomeness and body-wide influence as injection.

Abstract translation: 适用于皮肤给药的褥疮治疗方法含有ubidecarenone作为有效成分。 可以优选采用霜剂，洗剂或软膏形式的褥疮治疗有效减少褥疮相关的严重疼痛并恢复褥疮损伤的组织。 甚至适用于由于dys妄或颅神经紊乱而无法自己口服药物的患者。 它也没有像注射一样繁琐和全身的影响。

公开(公告)号：US5073375A

公开(公告)日：1991-12-17

申请号：US561707

申请日：1990-08-02

Applicant: Mitsuhiro Yoshida ,  Yutaka Morita ,  Yoshio Ishino ,  Shigemitsu Ohsawa

Inventor： Mitsuhiro Yoshida ,  Yutaka Morita ,  Yoshio Ishino ,  Shigemitsu Ohsawa

IPC: A61K9/00 ,  A61K9/70 ,  A61K31/445 ,  A61K47/00 ,  A61K47/14 ,  A61P17/00 ,  A61P21/02 ,  A61P25/04 ,  A61P29/00

CPC classification number: A61K9/7053 ,  A61K31/445 ,  A61K47/14 ,  A61K9/0014 ,  A61K9/7076 ,  Y10S514/906

Abstract: A pharmaceutical preparation for the percutaneous administration comprises eperisone or tolperisone, including salts thereof, and a monoglyceride of an aliphatic acid having 8 to 12 carbon atoms or/and an ester of lactic acid with an aliphatic alcohol having 12 to 18 carbon atoms. It is improved in the percutaneous absorption.

公开(公告)号：US5059427A

公开(公告)日：1991-10-22

申请号：US193713

申请日：1988-05-13

Applicant: Mitsuhiro Yoshida ,  Yutaka Morita ,  Yoshio Ishino ,  Shigemitsu Ohsawa

Inventor： Mitsuhiro Yoshida ,  Yutaka Morita ,  Yoshio Ishino ,  Shigemitsu Ohsawa

IPC: A61K9/00 ,  A61K9/70 ,  A61K31/445 ,  A61K47/00 ,  A61K47/14 ,  A61P17/00 ,  A61P21/02 ,  A61P25/04 ,  A61P29/00

CPC classification number: A61K9/7053 ,  A61K31/445 ,  A61K47/14 ,  A61K9/0014 ,  A61K9/7076 ,  Y10S514/906

Abstract: A pharmaceutical preparation for the percutaneous administration comprises eperisone or tolperisone, including salts thereof, and a monoglyceride of an aliphatic acid having 8 to 12 carbon atoms or/and an ester of lactic acid with an aliphatic alcohol having 12 to 18 carbon atoms. It is improved in the percutaneous absorption.

公开(公告)号：US5035895A

公开(公告)日：1991-07-30

申请号：US300407

申请日：1989-01-20

Applicant: Koichi Shibusawa ,  Shigemitsu Ohsawa

Inventor： Koichi Shibusawa ,  Shigemitsu Ohsawa

IPC: A61K31/685 ,  A61K9/10 ,  A61K9/107 ,  A61K47/10 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26

CPC classification number: A61K9/1075 ,  A61K47/183 ,  A61K47/26

Abstract: An aqueous solution comprises a fat-soluble substance, a phosphatide, a polyhydric alcohol and a basic amino acid, a salt thereof or Meglumin. It is uniformly emulsified and solubilized for the pharmaceutical use.