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1.发明授权Use of biocistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation 失效使用生物顺反子DNA构建体来鉴定抑制IRES依赖性翻译的化合物公开(公告)号：US07588885B2
公开(公告)日：2009-09-15
申请号：US11781596
申请日：2007-07-23
申请人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
发明人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
CPC分类号： C12Q1/6897 , C12N15/67
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
摘要翻译： 本发明涉及双顺反子DNA构建体用于鉴定抑制感染性肠病毒（EV）或脑心肌炎病毒（EMCV）的IRES依赖性翻译活性而不影响宿主受试者的依赖于CAP的翻译活性的化合物的用途。 所鉴定的化合物可用于制备用于治疗EV或EMCV感染的药物。
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2.发明申请Use of Biocistronic DNA Constructs for Identifying Compounds that Inhibit IRES-Dependent Translation 审中-公开使用生物顺反子DNA构建体鉴定抑制IRES依赖性翻译的化合物公开(公告)号：US20080242734A1
公开(公告)日：2008-10-02
申请号：US11781564
申请日：2007-07-23
申请人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
发明人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
CPC分类号： C12Q1/6897 , C12N15/67
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
摘要翻译： 本发明涉及双顺反子DNA构建体用于鉴定抑制感染性肠病毒（EV）或脑心肌炎病毒（EMCV）的IRES依赖性翻译活性而不影响宿主受试者的依赖于CAP的翻译活性的化合物的用途。 所鉴定的化合物可用于制备用于治疗EV或EMCV感染的药物。
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3.发明申请公开(公告)号：US20080241922A1
公开(公告)日：2008-10-02
申请号：US11781596
申请日：2007-07-23
申请人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
发明人： Tzong-Yuan Wu , Shin-Jhan Zeng , Ying-Ju Chen , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn
IPC分类号： C12N5/10
CPC分类号： C12Q1/6897 , C12N15/67
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
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4.发明授权Use of biscistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation 失效使用双顺反子DNA构建体来鉴定抑制IRES依赖性翻译的化合物公开(公告)号：US07262051B2
公开(公告)日：2007-08-28
申请号：US10913269
申请日：2004-08-06
申请人： Tzong-Yuan Wu , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn , Shin-Jhan Zeng , Ying-Ju Chen
发明人： Tzong-Yuan Wu , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn , Shin-Jhan Zeng , Ying-Ju Chen
CPC分类号： C12Q1/6897
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
摘要翻译： 本发明涉及双顺反子DNA构建体用于鉴定抑制感染性肠病毒（EV）或脑心肌炎病毒（EMCV）的IRES依赖性翻译活性而不影响宿主受试者的依赖于CAP的翻译活性的化合物的用途。 所鉴定的化合物可用于制备用于治疗EV或EMCV感染的药物。
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5.发明申请Use of biscistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation 失效使用双顺反子DNA构建体来鉴定抑制IRES依赖性翻译的化合物公开(公告)号：US20060024680A1
公开(公告)日：2006-02-02
申请号：US10913269
申请日：2004-08-06
申请人： Tzong-Yuan Wu , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn , Shin-Jhan Zeng , Ying-Ju Chen
发明人： Tzong-Yuan Wu , Tsu-An Hsu , Shin-Ru Shih , Suey-Sheng Kao , Tzyy-Rong Jinn , Shin-Jhan Zeng , Ying-Ju Chen
CPC分类号： C12Q1/6897
摘要： The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.
摘要翻译： 本发明涉及双顺反子DNA构建体用于鉴定抑制感染性肠病毒（EV）或脑心肌炎病毒（EMCV）的IRES依赖性翻译活性而不影响宿主受试者的依赖于CAP的翻译活性的化合物的用途。 所鉴定的化合物可用于制备用于治疗EV或EMCV感染的药物。
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